All about Drugs Live by Dr Anthony Melvin Crasto
Dorzagliatin Dorzagliatin(18)was developed by Hua Medicine as a treatment for diabetic kidney disease(DKD), type1diabetes mellitus(T1DM), and type2 diabetes mellitus (T2DM). CHINA 2022 Dorzagliatin is a glucokinase activator that is being developed to treat diabetes.[1] Unlike other diabetes drugs, it is intended to increase insulin sensitivity.[2] Dorzagliatin is under investigation in clinical trial NCT03173391 (Long-term Efficacy and Safety of HMS5552 …
Chiglitazar CAS 743438-45-1 Ingredient UNII CAS InChI Key Chiglitazar sodium, (S)- YN12H6OCV6 2390374-10-2 RMVIEXHXRDCWBT-UCRKPPETSA-M Chiglitazar was developed by Chipscreen Biosciences and was approved in China for improving glycemic control in adultpatients with type2 diabetes in October2021. Chiglitazar (trade name Bilessglu) is a drug for the treatment of type 2 diabetes.[1] It is a peroxisome proliferator-activated receptor (PPAR) agonist. In China, chiglitazar is …
Vamorolone CAS 13209-41-1 Molecular Weight 356.46 Formula C22H28O4 Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects. Vamorolone, sold under the brand name Agamree, is a synthetic corticosteroid, which is used for the treatment of Duchenne muscular dystrophy.[4][5][6][7][8] It is taken by mouth.[1] It is …
Tebapivat CAS 2283422-04-6 WeightAverage: 392.44Monoisotopic: 392.116778341 Chemical FormulaC18H16N8OS 10-[(6-aminopyridin-2-yl)methyl]-7-methyl-4-(1H-pyrazol-5-ylmethyl)-3-thia-5,7,10,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),4,11-tetraen-9-one6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5′,4′:4,5]pyrrolo[2,3-d]pyridazin-5-one 6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5′,4′:4,5]pyrrolo[2,3-d]pyridazin-5-one Tebapivat is under investigation in clinical trial NCT05490446 (A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-risk Myelodysplastic Syndromes (LR-MDS)). Tebapivat is an orally available activator of the red cell isoform of pyruvate kinase (PK-R; PKR), with potential to improve hemolytic anemia and related-symptoms …
Tagtociclib (PF-07104091), 2460249-19-6, MW 404.5, C19H28N6O4 CAS 2733575-91-0 HYDRATE Molecular Weight HYDRATE 422.48 Formula C19H30N6O5 [(1R,3S)-3-[3-[[5-(methoxymethyl)-2-methylpyrazole-3-carbonyl]amino]-1H-pyrazol-5-yl]cyclopentyl] N-propan-2-ylcarbamate PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2). Phase IIBreast cancer; Solid tumours Phase I/IINon-small cell lung cancer; Ovarian cancer; Small cell …
SPIROBUDIFEN cas 1305319-70-3 413.3 g/mol, C20H22Cl2O5 Butyl 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl carbonate Butyl 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl carbonate Spirobudifen is an oxaspiro compound that is 1-oxaspiro[4.5]dec-3-en-2-one substituted by 2,4-dichlorophenyl and (butoxycarbonyl)oxy groups at positions 3 and 4, respectively. It is an acaricide from Zhejiang Udragon Bioscience. It is a dichlorobenzene, an oxaspiro compound, an organochlorine acaricide and a carbonate ester. SCHEME PATENTS CN112745286 CN102060818 …
Hetrombopag Olamine, RAFUTROMBOPAG OLAMINE 2-aminoethanol;5-[2-hydroxy-3-[[5-methyl-3-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-4-yl]diazenyl]phenyl]furan-2-carboxylic acid (Z)-5-(2-Hydroxy-3-(2- (3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen- 2-yl)-1H-pyrazol-4(5H)-ylidene)hydrazinyl)phenyl) furan-2-carboxylic acid diethanolamine CAS 1257792-42-9 1257792-41-8 (free acid) 1257792-41-8 (ethanolamine) 1257792-42-9 (olamine) Jiangsu Hengrui Pharmaceutical, was approved in China in June 2021 for treatment of adult patients with chronic primary immune thrombocytopenia (ITP) and severe aplastic anemia who have not responded well to other treatments Hetrombopag Olamine is the orally …
SOVESUDIL PHP-201; AMA 0076, C23O3R93BM CAS 1333400-14-8 Molecular Weight 407.44 Formula C23H22FN3O3 Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia. SCHEME PATENTS Bioorganic & Medicinal Chemistry Letters (2013), 23(23), 6442-6446 https://www.sciencedirect.com/science/article/abs/pii/S0960894X13011141 10.1016/j.bmcl.2013.09.040 Figure 2. …
Contezolid WeightAverage: 408.337Monoisotopic: 408.104539468 Chemical FormulaC18H15F3N4O4 Shanghai MicuRx Pharmaceutical Co. Ltd Contezolid was approved for use by the National Medical Products Administration (NMPA) of China in 2021 Contezolid (trade name Youxitai) is an antibiotic of the oxazolidinone class.[1][2] It is effective against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Streptococcus agalactiae, and other bacteria.[3] In 2021, it was approved by the National Medical Products Administration of China for the …
CAS 1011529-10-4 WeightAverage: 286.223Monoisotopic: 286.082581021 Chemical FormulaC9H11FN6O4 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one Azvudine is an antiviral drug which acts as a reverse transcriptase inhibitor.[3] It was discovered for the treatment of hepatitis C[4] and has since been investigated for use against other viral diseases such as AIDS and COVID-19,[2][5] for which it was granted conditional approval in China.[6][7] Azvudine was first discovered in 2007.[8] It costs 350 Chinese yuan per 7 days for …