It’s only fair to share… ETRUMADENANT CAS 2239273-34-6 C23 H22 N8 O, 426.47 Benzonitrile, 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl- 3-[2-Amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methylbenzonitrile AB 928 Arcus Biosciences is developing etrumadenant, the lead from the small molecule adenosine (A2a/A2b) dual receptor antagonist program, for treating cancer. In November 2020, preliminary data from ARC-7 in metastatic NSCLC were expected to report in the first half of 2021. OriginatorArcus Biosciences …
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Amikacin sulfate
It’s only fair to share… Amikacin sulfate アミカシン硫酸塩 , BB K 8 Formula C22H43N5O13. 2H2SO4 CAS 39831-55-5 FREE 37517-28-5 Mol weight 781.7595 EU APPROVED, 2020/10/27, Arikayce liposomal Antibacterial, Protein biosynthesis inhibitor (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid Amikacin CAS Registry Number: 37517-28-5 CAS Name: O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[6-amino-6-deoxy-a-D-glucopyranosyl-(1®4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Additional Names: 1-N-[L(-)-4-amino-2-hydroxybutyryl]kanamycin A Molecular Formula: C22H43N5O13 Molecular Weight: 585.60 Percent Composition: C 45.12%, H 7.40%, N 11.96%, O 35.52% Literature References: Semisynthetic aminoglycoside …
Tirbanibulin
It’s only fair to share… Tirbanibulin CAS 897016-82-9, 1038395-65-1 DI HCL 1080645-95-9 MESYLATE N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide Molecular Weight 431.53 Formula C₂₆H₂₉N₃O₃ FDA APPROVED 12/14/2020, Klisyri To treat actinic Keratosis of the face or scalp Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Originator Kinex Pharmaceuticals Developer Almirall S.A.; Athenex; Hanmi Pharmaceutical; …
Gallium 68 PSMA-11
It’s only fair to share… Gallium 68 PSMA-11 FDA APPROVED, 12/1/2020, Gallium 68 PSMA-11 For detection and localization of prostate cancer Press Release Drug Trials Snapshot Chemical structure of 18F-labeled radiotracers. [18F]DCFPyL (A), [18F]PSMA-1007 (B), [18F]CTT1057 (C), (D) [18F]JK-PSMA-7 and (E) [18F]AIF-PSMA-11. The urea backbone of (A), (B), (D) and (E) is marked in blue, while the phosphoramidate …
Setmelanotide
It’s only fair to share… Setmelanotide Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2 Molecular FormulaC49H68N18O9S2 Average mass1117.309 Da N-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide (2->8)-disulfide 1,2-Dithia-5,8,11,14,17,20-hexaazacyclotricosane-4-carboxamide, 22-[[(2S)-2-(acetylamino)-5-[(diaminomethylene)amino]-1-oxopentyl]amino]-10-[3-[(diaminomethylene)amino]propyl]-16-(1H-imidazol-5-ylmeth yl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-13-(phenylmethyl)-, (4R,7S,10S,13R,16S,19R,22R)- [ACD/Index Name] 10011 920014-72-8 [RN] Imcivree [Trade name] N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-Ltryptophyl- L-cysteinamide, cyclic (2-8)-disulfide N7T15V1FUY RM-493, BIM-22493 UNII-N7T15V1FUY сетмеланотид [Russian] [INN] سيتميلانوتيد [Arabic] [INN] 司美诺肽 [Chinese] [INN] (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide FDA 11/25/2020, Imcivree, To treat obesity and the control of hunger associated with pro-opiomelanocortin deficiency, a rare disorder that causes severe obesity …
Melatonin
It’s only fair to share… Melatonin メラトニン Formula C13H16N2O2 CAS73-31-4 73-31-4 Mol weight 232.2783 APPROVED, Melatobel, JAPAN 2020/3/25 200-659-6 [EINECS] 200-797-7 [EINECS] 205542 [Beilstein] 73-31-4 [RN] Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-Acetamide Melatonin CAS Registry Number: 73-31-4 CAS Name: N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide Additional Names: N-acetyl-5-methoxytryptamine Trademarks: Regulin (Young) Molecular Formula: C13H16N2O2 Molecular Weight: 232.28 Percent Composition: C 67.22%, H 6.94%, N 12.06%, O 13.78% Literature References: A hormone of the pineal gland, also …
Tepotinib hydrochloride
It’s only fair to share… Tepotinib hydrochloride CS-977;Tepotinib;Veledimex;MSC2156119;EMD-1214063 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile;hydrate;hydrochloride Benzonitrile, 3-(1,6-dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo-3-pyridazinyl)-, hydrochloride, hydrate 3- (1- {3- [5- (1-methylpiperidin-4-ylmethoxy) pyrimidine) -2-yl] -benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl) -benzonitrile тепотиниб [Russian] [INN] تيبوتينيب [Arabic] [INN] 特泊替尼 [Chinese] [INN] 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile 3-{1-[(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazin-3-yl}benzonitrile EMD 1214063 MSC 2156119 Formula C29H28N6O2. HCl. H2O C29H28N6O2FREE CAS 1946826-82-9 HCL.H2O CAS No. FREE 1100598-32-0 Mol weight 547.0478 492.57 FREE JAPAN 25/3 2020 APPROVED, Tepmetko Antineoplastic, …
Tirabrutinib
It’s only fair to share… Tirabrutinib チラブルチニブ塩酸塩 GS-4059 ONO-4059 6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one Formula C25H22N6O3. HCl CAS 1439901-97-9 HCL 1351636-18-4FREE FORM Mol weight 490.9415 JAPAN APPROVED 2020/3/25 Velexbru Antineoplastic, Bruton’s tyrosine kinase inhibitor 8H-Purin-8-one,6-amino-7,9-dihydro-9-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl) 6-Amino-9-((3R)-1-(2-butynoyl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one Tirabrutinib (Velexbru®) is an orally administered, small molecule, Bruton’s tyrosine kinase (BTK) inhibitor being developed by Ono Pharmaceutical and its licensee Gilead Sciences for …
Berotralstat
It’s only fair to share… Berotralstat CAS 1809010-50-1 DIHCl 1809010-52-3 Molecular Formula, C30-H26-F4-N6-O, Molecular Weight, 562.5684 1-(3-(Aminomethyl)phenyl)-N-(5-((R)-(3-cyanophenyl)((cyclopropylmethyl)amino)methyl)-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 1H-Pyrazole-5-carboxamide, 1-(3-(aminomethyl)phenyl)-N-(5-((R)-(3-cyanophenyl)((cyclopropylmethyl)amino)methyl)-2-fluorophenyl)-3-(trifluoromethyl)- To treat patients with hereditary angioedema FDA APPROVED 12/4/2020, Orladeyo, 110MG CAPSULE 0RAL New Drug Application (NDA): 214094 Company: BIOCRYST PHARMACEUTICALS INC New Drug Application (NDA): 214094 Company: BIOCRYST PHARMACEUTICALS INC Berotralstat Hydrochloride 1-[3-(Aminomethyl)phenyl]-N-(5-{(1R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide dihydrochloride C30H26F4N6O▪2HCl : 635.48 [1809010-52-3] Berotralstat, also known as BCX-7353, is a kallikrein inhibitor. BCX7353 …
Viltolarsen
It’s only fair to share… Viltolarsen 维托拉生 ビルトラルセン Formula C244H381N113O88P20 CAS 2055732-84-6 Mol weight 6924.8155 APPROVED FDA 2020/8/12, Viltepso APPROVED JAPAN PMDA 2020/3/25, VILTEPSO NCNP-01 NS-065 NS-065/NCNP-01 WHO 10771 WHO-10771 NAME DOSAGE STRENGTH ROUTE LABELLER MARKETING START MARKETING END Viltepso Injection, solution 250 mg/1 Intravenous Ns Pharma, Inc. 2020-08-13 Not applicable SYN Watanabe N, Nagata T, Satou …