Category «Uncategorized»

BMS-986115

It’s only fair to share… BMS-986115 CAS 1584647-27-7 (2R,3S)-N-((3S)-5-(3-Fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-lH-l,4-benzodiazepin- 3-yl)-2, -bis(3,3,3-trifluoropropyl)succinamide MW: 574.4945,  C26-H25-F7-N4-O3, UNII: LSK1L593UU 10-Nitrooleate, CTK3B7458, CTK3C3167, 9-Octadecenoic acid, 10-nitro-, 875685-46-4, AG-L-63109, 9-Octadecenoic acid, 10-nitro-, (9E)-, 88127-53-1 FOR advanced solid tumors Originator Bristol-Myers Squibb Class Antineoplastics Mechanism of Action Amyloid precursor protein secretase inhibitors; Notch signalling pathway inhibitors Phase I Solid tumours Most Recent Events 30 Aug 2016Bristol-Myers Squibb …

BMS 906024

It’s only fair to share… BMS 906024 cas 1401066-79-2 MF C26H26F6N4O3 MW 556.500 (2R,3S)-N-[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)succinamide Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2R,3S)- (2R,35)-N-((35)-l-Methyl-2-oxo-5-phenyl-2,3-dihydro-lH-l,4-benzodiazepin-3-yl)-3- (2,2,2-trifluoroethyl)-2-(3,3,3-trifluoropropyl)succinamide Claude Quesnelle, Soong-Hoon Kim, Francis Lee, Ashvinikumar Gavai Applicant Bristol-Myers Squibb Company Ashvinikumar Gavai   Claude Quesnelle Senior Research Investigator/Chemist at Bristol-Myers Squibb RICHARD LEE BMS-906024 is a novel, potent Notch receptor inhibitor . Cancers have a tendency …

MCC 950

It’s only fair to share… MCC 950 256373-96-3 (sodium salt); 210826-40-7 (free form). MCC950; CP-456773; CAS 210826-40-7; DSSTox_CID_27301; DSSTox_RID_82252; DSSTox_GSID_47301; CP-456,773; CRID3 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea C20H24N2O5S Molecular Weight: 404.47996 g/mol CP-456773, also known as MCC950 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin …

BMT-145027

It’s only fair to share… BMT-145027 CAS ? C23H14ClF3N4 Exact Mass: 438.0859 3-(4-chloro-3-(trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 3-(4-chloro-3- (trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 1H NMR (600 MHz, DMSO-d6) δ = 14.46 (br. s., 1H), 8.24 (s, 1H), 8.14 (d, J=8.1 Hz, 1H), 7.88 (d, J=8.3 Hz, 1H), 7.84 (dd, J=6.1, 2.7 Hz, 2H), 7.61 – 7.55 (m, 3H), 2.50 – 2.45 (m, 1H), …

VADADUSTAT, вададустат , فادادوستات , 伐达度司他 ,

It’s only fair to share… VADADUSTAT AKB-6548, PG-1016548 PG1016548, UNII:I60W9520VV, B-506 CAS 1000025-07-9 [5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxamido]acetic acid N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine MF C14H11ClN2O4 , 306.0407 вададустат [Russian] [INN] فادادوستات [Arabic] [INN] 伐达度司他 [Chinese] [INN] 2-(5-(3-Chlorophenyl)-3-hydroxypicolinamido)acetic acid A1Z N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycine US8598210, 118 [5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxamido]acetic acid 1000025-07-9 [RN] 10289 AKB-6548 Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- [ACD/Index Name] I60W9520VV N-[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]glycine N-{[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl}glycine [ACD/IUPAC Name] PG1016548 UNII:I60W9520VV Inventors Richard Kawamoto Original Assignee The Procter & Gamble Company for Treatment of Anemia associated …

Avibactam

It’s only fair to share… NXL-104, Avibactam trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt (e.g., NXL-104) CAS 396731-20-7, 1192491-61-4 AVE-1330 AVE-1330A PHASE 1 a broad-spectrum intravenous beta-lactamase inhibitor, was under development for the treatment of infections due to nosocomial drug resistant Gram-negative bacteria SANOFI  INNOVATOR Novexel holds exclusive worldwide development and commercialization rights from Sanofi. NXL104; Avibactam; UNII-7352665165; Molecular Formula: C7H11N3O6S Molecular Weight: …

Clenbuterol

It’s only fair to share… Clenbuterol Clenbuterol hydrochloride, NAB-365, Siropent Clenbuterol, marketed as Dilaterol, Spiropent, Ventipulmin,[1] is a sympathomimetic amine used by sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders such as asthma use this as a bronchodilator to make breathing easier. It is most commonly available as the …

Tedatioxetine Revisited

It’s only fair to share… Tedatioxetine TEDATIOXETINE; UNII-5H681S8O3S; Lu AA24530; 508233-95-2; Molecular Formula: C18H21NS Molecular Weight: 283.43104 g/mol 4-{2-[(4-Méthylphényl)sulfanyl]phényl}pipéridine 508233-95-2 [RN] Lu AA24530 Piperidine, 4-[2-[(4-methylphenyl)thio]phenyl] OriginatorLundbeck A/S DeveloperLundbeck A/S; Takeda ClassAntidepressants; Anxiolytics; Piperidines Mechanism of ActionBiogenic monoamine uptake inhibitors; Serotonin 2C receptor antagonists; Serotonin 3 receptor antagonists Generalised anxiety disorder; Major depressive disorder Most Recent …

GNE-272

It’s only fair to share… GNE-272 (S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4- yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin- 5(4H)-yl)ethanone 1-[3-[2-fluoro-4-(1-methylpyrazol-4-yl)anilino]-1-[(3S)-oxolan-3-yl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]ethanone CAS 1936428-93-1 Molecular Formula: C22H25FN6O2 Molecular Weight: 424.471303 g/mol GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080-4990 (US). CONSTELLATION PHARMACEUTICALS, INC. [US/US]; 215 First Street Suite 200 Cambridge, Massachusetts 02142 (US) ROMERO, F. Anthony; (US). MAGNUSON, Steven; (US). PASTOR, Richard; (US). TSUI, Vickie …

Consumption of a bioactive compound from Neem plant could significantly suppress development of prostate cancer

It’s only fair to share… (From left to right) Principal Investigator Associate Professor Gautam Sethi and NUS PhD candidate Ms Zhang Jingwen from the Department of Pharmacology at the NUS Yong Loo Lin School of Medicine led a research which found that a bioactive compound from the neem plant could significantly suppress development of prostate …