Category «Uncategorized»

Enarodustat

It’s only fair to share…   Enarodustat エナロデュスタット JTZ 951 Formula C17H16N4O4 CAS 1262132-81-9 Mol weight 340.3333 PMDA 2020/9/25 APPROVED ENAROY Anti-anemic, Hypoxia inducible factor-prolyl hydroxylase (HIF-PH) inhibitor Originator Japan Tobacco Developer Japan Tobacco; JW Pharmaceutical Class Acetic acids; Amides; Antianaemics; Pyridones; Small molecules; Triazoles Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors Preregistration Anaemia 27 Dec …

Sofpironium bromide ソフピロニウム臭化物

It’s only fair to share… Sofpironium bromide ソフピロニウム臭化物 BBI 4000 [(3R)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Formula C22H32NO5. Br CAS 1628106-94-4 BASE 1628251-49-9 Mol weight 470.3972 PMDA APPROVED JAPAN 2020/9/25, Ecclock Anhidrotic Sofpironium Bromide 1-ambo-(3R)-3-{[(R)-(Cyclopentyl)hydroxy(phenyl)acetyl]oxy}-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidinium bromide C22H32BrNO5 : 470.4 [1628106-94-4] SYN PATENT WO 2018026869 https://patents.google.com/patent/WO2018026869A1/en Certain glycopyrronium salts and related compounds, as well as processes for making and methods of using these glycopyrronium salts and …

Tetrahydrobiopterin

It’s only fair to share…     Sapropterin Sapropterin dihydrochloride, Dapropterin dihydrochloride, R-THBP, 6R-BH4, SUN-0588, Phenoptin, Biopten, Biobuden, Bipten Approval:US: Dec’07, EU: Dec’08 INNOVATOR BIOMARIN IUPAC Name (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3,4,5,6,7,8-hexahydropteridin-4-one SMILES [H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)O сапроптерин [Russian] [INN] سابروبتيرين [INN] 沙丙蝶呤 [Chinese] [INN] 17528-72-2 27070-47-9 Sun 0588 6R-BH4 R-THBP Sapropterin Sapropterina sapropterinum Tetrahydrobiopterin Title: Sapropterin CAS Registry Number: 62989-33-7 CAS Name: (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone Additional Names: (6R)-L-erythro-tetrahydrobiopterin; dapropterin; R-THBP; 6R-BH4 Molecular Formula: C9H15N5O3 Molecular …

Abametapir アバメタピル , абаметапир , أباميتابير , 阿巴甲吡 ,

It’s only fair to share…   Abametapir アバアバメタピル , абаметапир , أباميتابير , 阿巴甲吡 , 5,5′-dimethyl-2,2′-bipyridine, 6,6′-Bi-3-picoline BRN 0123183 HA 44 HA-44 HA44 Formula C12H12N2 CAS 1762-34-1 Mol weight 184.2371 Xeglyze, FD APPROVED 24/7/2020 Pediculicide, Metalloproteinase inhibitor   Disease Head lice infestation Originator Hatchtech DeveloperDr Reddys Laboratories; Hatchtech ClassAntiparasitics; Heterocyclic compounds; Pyridines; Small molecules Mechanism of ActionChelating agents; Metalloprotease inhibitors Registered Pediculosis 27 Jul …

Bulevirtide acetate

It’s only fair to share…   Bulevirtide acetate (N-Myristoyl-glycyl-L-threonyl-L-asparaginyl-L-leucyl-L-seryl-L-valyl-Lprolyl-L-asparaginyl-L-prolyl-L-leucyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-aspartyl-L-histidyl-Lglutaminyl-L-leucyl-L-aspartyl-L-prolyl-L-alanyl-L-phenylalanyl-glycyl-L-alanyl-L-asparaginyl-L-seryl-Lasparaginyl-L-asparaginyl-Lprolyl-L-aspartyl-L-tryptophanyl-L-aspartyl-L-phenylalanyl-L-asparaginyl-L-prolylL-asparaginyl-L-lysyl-L-aspartyl-L-histidyl-L-tryptophanyl-L-prolyl-L-glutamyl-L-alanyl-L-asparaginyl-L-lysylL-valylglycinamide, acetate salt. molecular formula C248H355N65O72, molecular mass is 5398.9 g/mol ブレビルチド酢酸塩; APROVED 2020/7/31, EU, Hepcludex MYR GmbH Antiviral, Entry inhibitor   Disease Hepatitis delta virus infection Bulevirtide is a 47-amino acid peptide with a fatty acid, a myristoyl residue, at the N-terminus and an amidated C-terminus. The active substance …

Nifurtimox

It’s only fair to share… Nifurtimox Formula C10H13N3O5S CAS 23256-30-6 Mol weight 287.2923 FDA APPROVED, 2020/8/6, LAMPIT Antiprotozoal   Disease Chagas disease IUPAC Name 3-methyl-4-[(E)-[(5-nitrofuran-2-yl)methylidene]amino]-1lambda6-thiomorpholine-1,1-dione SMILES CC1CS(=O)(=O)CCN1\N=C\C1=CC=C(O1)[N+]([O-])=O SYN Danong Chen, Glenn Rice. 2013. Novel formulations of nitrofurans including nifurtimox with enhanced activity with lower toxicity.US20150140089A1 melting point (°C) 177-183 https://www.chemicalbook.com/ChemicalProductProperty_US_CB3903922.aspx OriginatorBayer ClassAntiprotozoals; Nitrofurans; Small molecules; Thiamorpholines; Thiazines …

Pralsetinib

It’s only fair to share… Pralsetinib Formula C27H32FN9O2 CAS 2097132-94-8 Mol weight 533.6005 Cyclohexanecarboxamide, N-[(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]-, cis– 2097132-94-8 [RN] BLU-667 BS-15942 Other Names cis-N-[(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxamide BLU 123244 BLU 667 Pralsetinib X 581238 cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)pyridin-3-yl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxamide FDA APPROVED GAVRETO, 2020/9/4 Pralsetinib, sold under the brand name Gavreto, is a medication for the treatment of metastatic RET fusion-positive non-small cell lung cancer (NSCLC).[1] Pralsetinib is a …

Clascoterone

It’s only fair to share… Clascoterone (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate Formula C24H34O5 CAS 19608-29-8 Mol weight 402.5238 FDA APPROVED, 2020/8/26, Winlevi クラスコステロン; Anti-acne, Androgen receptor antagonist Clascoterone, sold under the brand name Winlevi, is an antiandrogen medication which is used topically in the treatment of acne.[1][2][3] It is also under development for the treatment of androgen-dependent scalp hair loss.[2] The medication is used as a cream by application to the skin, …

Somapacitan, ソマパシタン;

It’s only fair to share… FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS CVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F (Disulfide bridge: 53-165, 182-189) Somapacitan FDA APPROVED, 2020/8/28, SOGROYA Growth hormone (GH) receptor agonist CAS: 1338578-34-9 (2S)-5-[2-[2-[2-[[(2S)-1-amino-6-[[2-[(2R)-2-amino-2-carboxyethyl]sulfanylacetyl]amino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-[[(4S)-4-carboxy-4-[[2-[2-[2-[4-[16-(2H-tetrazol-5-yl)hexadecanoylsulfamoyl]butanoylamino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]-5-oxopentanoic acid Formula C1038H1609N273O319S9 Mol weight 23305.1048 JAP ソマパシタン; Treatment of growth hormone dificiency albumin-binding growth …

Odevixibat

It’s only fair to share… Odevixibat A-4250, AR-H 064974 CAS 501692-44-0 BUTANOIC ACID, 2-(((2R)-2-((2-((3,3-DIBUTYL-2,3,4,5-TETRAHYDRO-7-(METHYLTHIO)-1,1-DIOXIDO-5-PHENYL-1,2,5-BENZOTHIADIAZEPIN-8-YL)OXY)ACETYL)AMINO)-2-(4-HYDROXYPHENYL)ACETYL)AMINO)-, (2S)- (2S)-2-[[(2R)-2-[[2-[(3,3-dibutyl-7-methylsulfanyl-1,1-dioxo-5-phenyl-2,4-dihydro-1λ6,2,5-benzothiadiazepin-8-yl)oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid Molecular Formula C37H48N4O8S2 Molecular Weight 740.929 AZD8294WHO 10706AR-H064974HY-109120CS-0078340D11716US9694018, 5Originator Albireo AB Developer Albireo AB; Albireo Pharma ClassAcetamides; Butyric acids; Hepatoprotectants; Small molecules; Sulfones; Thiazepines Mechanism of Action Sodium-bile acid cotransporter inhibitors Orphan Drug Status Yes – Primary biliary cirrhosis; Biliary atresia; Intrahepatic cholestasis; Alagille …