It’s only fair to share… SELGANTOLIMOD GS 9688 RN: 2004677-13-6 UNII: RM4GJT3SMQ Molecular Formula, C14-H20-F-N5-O, Molecular Weight, 293.344 1-Hexanol, 2-((2-amino-7-fluoropyrido(3,2-d)pyrimidin-4-yl)amino)-2-methyl-, (2R)- (2R)-2-((2-Amino-7-fluoropyrido(3,2-d)pyrimidin-4-yl)amino)-2-methylhexan-1-ol Discovery of GS–9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B Journal of Medicinal Chemistry, Articles ASAP (Drug Annotation) Publication Date (Web):May 14, 2020DOI: 10.1021/acs.jmedchem.0c00100 https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.0c00100/suppl_file/jm0c00100_si_002.pd PATENTS Patent ID …
Category «Uncategorized»
Favipiravir, ファビピラビル
It’s only fair to share… FAVIPIRAVIR FAVIPIRAVIR Toyama (Originator) RNA-Directed RNA Polymerase (NS5B) Inhibitors Chemical Formula: C5H4FN3O2 CAS #: 259793-96-9 Molecular Weight: 157.1 ANTI-INFLUENZA COMPOUND clinical trials http://clinicaltrials.gov/search/intervention=Favipiravir Chemical Name: 6-fluoro-3-hydroxy-2-pyrazinecarboxamide Synonyms: T-705, T705, Favipiravir Molecular FormulaC5H4FN3O2 Average mass157.103 Da 259793-96-9 [RN] 2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo- 6-Fluoro-3-hydroxypyrazine-2-carboxamide 6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxamide 8916 Avigan ファビピラビル Favipiravir 6-Fluoro-3-hydroxypyrazine-2-carboxamide C5H4FN3O2 : 157.1 [259793-96-9] https://www.pmda.go.jp/files/000210319.pdf The drug …
Camostat Mesilate, カモスタットメシル酸塩 日局収載
It’s only fair to share… Camostat Molecular FormulaC20H22N4O5 Average mass398.413 Da 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester 4-{2-[2-(Dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate 59721-28-7 [RN] Benzeneacetic acid, 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethyl ester Camostat Mesilate カモスタットメシル酸塩 日局収載 Trypsin-like protease inhibitor CAS 59721-29-8 C20H22N4O5.CH4O3S 494.52 MP 194, methanol, diethyl ether, Chemical and Pharmaceutical Bulletin, 2005, vol. 53, 8, pg. 893 – 898 カモスタットメシル酸塩 日局収載 Camostat Mesilate Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate monomethanesulfonate C20H22N4O5▪CH4O3S : 494.52 [59721-29-8] Launched – 1985, in Japan …
Remdesivir, レムデシビル , ремдесивир , ريمديسيفير , 瑞德西韦 ,
It’s only fair to share… Remdesivir Formula C27H35N6O8P CAS 1809249-37-3 Mol weight 602.576 レムデシビル UNII:3QKI37EEHE ремдесивир [Russian] [INN] ريمديسيفير [Arabic] [INN] 瑞德西韦 [Chinese] [INN] 2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) L-Alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile 2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl (2S)-2-[[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate 2-Ethylbutyl N-[(S)-[2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitril-6-O-yl]phenoxyphosphoryl]-L-alaninate GS 5734 L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester,6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile GS-5734 Treatment of viral infections Phase III, clinical trials for the treatment …
LANRAPLENIB
It’s only fair to share… LANRAPLENIB GS-9876 Phase II, GILEAD Phase II Gilead Cutaneous lupus erythematosus Rheumatoid arthritis Sjogren syndrome GS-9876 LANRAPLENIB Imidazo(1,2-a)pyrazin-8-amine, 6-(6-amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)- 6-(6-Aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo|1,2-a]pyrazin-8-amine 6-(6-Amino-2-pyrazinyl)-N-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)imidazo(1,2-a)pyrazin-8-amine Molecular Weight 443.50 Formula C₂₃H₂₅N₉O CAS No. 1800046-95-0 Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib (GS-9876) …
ABBV 744
It’s only fair to share… ABBV 744 N-Ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide 1H-Pyrrolo[2,3-c]pyridine-2-carboxamide, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxy-1-methylethyl)phenyl]-6,7-dihydro-6-methyl-7-oxo- Molecular Weight 491.55 Formula C₂₈H₃₀FN₃O₄ CAS No. 2138861-99-9 ABBV-744 is a highly BDII-selective BET bromodomain inhibitor, used in the research of inflammatory diseases, cancer, and AIDS. Acute Myeloid Leukemia (AML) Phase I, AbbVie is evaluating oral agent ABBV-744 in early clinical trials for the treatment of metastatic castration …
NIDUFEXOR
It’s only fair to share… NIDUFEXOR LMB763 4-[[benzyl-(8-chloro-1-methyl-4H-chromeno[4,3-c]pyrazole-3-carbonyl)amino]methyl]benzoic acid Nidufexor is a farnesoid X receptor (FXR) agonist. Molecular Weight 487.93 Formula C₂₇H₂₂ClN₃O₄ CAS No. 1773489-72-7 PHASE 2 Treatment of Liver and Biliary Tract Disorders, Agents for Diabetic Nephropathy, NOVARTIS Nidufexor 1773489-72-7, LMB-763, UNII-CJ1PL0TE6J, CJ1PL0TE6J, BCP28929, EX-A1854 Nidufexor pound LMB-763 pound(c) ZINC584641402 4-((N-benzyl-8-chloro-1-methyl-1,4-dihydrochromeno[4,3-c]pyrazole-3-carboxamido)methyl)benzoic acid HY-109096 CS-0039398 https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01621 1 (7.6 g, 89% yield) as …
LNP 023
It’s only fair to share… LNP 023 CAS 1644670-37-0 ROTATION + 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid M.Wt 422.525 Formula C25H30N2O4 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid LNP023 RENRQMCACQEWFC-UGKGYDQZSA-N PATENT US9682968, Example-26a BDBM160475 ZINC223246892 HY-127105 CS-0093107 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid LNP023 (LNP-023) is a highly potent, reversible, selective inhibitor of factor B (IC50=10 nM), the proteolytically active component of the C3 and C5 convertases. …
Eptinezumab エプチネズマブ;
It’s only fair to share… Eptinezumab エプチネズマブ; (Heavy chain) EVQLVESGGG LVQPGGSLRL SCAVSGIDLS GYYMNWVRQA PGKGLEWVGV IGINGATYYA SWAKGRFTIS RDNSKTTVYL QMNSLRAEDT AVYFCARGDI WGQGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDARVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY ASTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K (Light …
Amisulpride, アミスルプリド ,
It’s only fair to share… Amisulpride FDA 2020, Barhemsys APPROVED, 2020/2/27 Name Amisulpride (INN); Deniban (TN); Solian (TN) アミスルプリド; Formula C17H27N3O4S CAS 71675-85-9 Mol weight 369.479 Antipsychotic, Dopamine receptor antagonist, Neuropsychiatric agent amisulpride(标准品) 275-831-7 [EINECS] Synthesis ReferenceUS4401822 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide Amisulpride CAS Registry Number: 71675-85-9 CAS Name: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide Additional Names: 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-o-anisamide; aminosultopride Manufacturers’ Codes: DAN-2163 Trademarks: Deniban (Synthelabo); Socian (Synthelabo); Solian (Synthelabo); Sulamid (Baldacci) Molecular Formula: C17H27N3O4S …