It’s only fair to share… Simple Metal-Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines (pages 1872–1878) Sami E. Varjosaari, Vladislav Skrypai, Paolo Suating, Joseph J. M. Hurley, Ashley M. De Lio, Thomas M. Gilbert and Marc J. Adler Version of Record online: 22 MAY 2017 | DOI: 10.1002/adsc.201700079 Simple Metal-Free Direct Reductive …
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Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions
It’s only fair to share… Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions Green Chem., 2017, 19,2931-2935 DOI: 10.1039/C7GC00789B, Communication O. N. Chupakhin, A. V. Shchepochkin, V. N. Charushin A simple and efficient electrochemical method for the synthesis of asymmetrical bi(het)aryls through direct functionalization of the C(sp2)-H bond in …
Synthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivatives
It’s only fair to share… SRM University Department of Chemistry Chennai, Tamil Nadu, India 3b R = NITRO http://nopr.niscair.res.in/handle/123456789/42358 Dr. S. Sathishkumar Assistant Professor in Chemistry, Kongu Engineering College, Perundurai, Erode – 638052 DR. HELEN P. KAVITHA Dr. Helen P. Kavitha Professor and Head of the Department E-mail: helen.p@rmp.srmuniv.ac.in Area: Chemistry Affiliation: Department of Chemistry, Ramapuram Campus, SRM …
Benzo[d]oxazol-2(3H)-one
It’s only fair to share… IH NMR ABOVE 13C NMR BELOW Benzo[d]oxazol-2(3H)-one (2a) pale yellow crystals; mp 140.5–141.5 °C (lit.(6a) 134–136 °C); 1H NMR (300 MHz, CDCl3) δ 9.90 (s, 1H), 7.26–7.09 (m, 4H); 13C NMR (75 MHz, CDCl3) δ 156.3, 143.9, 129.4, 124.2, 122.8, 110.3, 110.2. NMR PREDICT 1H NMR PREDICT 13C NMR PREDICT ////////// …
LOXO 195
It’s only fair to share… LOXO-195 CAS: 2097002-61-2 Chemical Formula: C20H21FN6O Molecular Weight: 380.4274 2097002-59-8 (RS-isomer) 1350884-56-8 (R racemic) Synonym: LOXO-195; LOXO 195; LOXO195. IUPAC: (13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one 10H-5,7-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one, 17-fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-, (12R,18bR)- SMILES Code: FC1=CN=C(CC[C@@H](C)NC(C2=C3N(C=CC4=N3)N=C2)=O)C([C@@H]5N4CCC5)=C1 LOXO-195 is a potent and selective TRK inhibitor capable of addressing potential mechanisms of acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or …
NaBH4, twin screw technology (i.e., granulator, melt extruder, etc.) to yield the desired product in a continuous manner
It’s only fair to share… In this work the application of green chemistry principles such as process intensification and the replacement of reagents and solvents to more benign alternatives were coupled with the advantages of continuous manufacturing. The reduction of lipophilic aromatic aldehydes using an aqueous alkaline solution of NaBH4 was achieved by means of …
Ascaridole
It’s only fair to share… Scheme 2. Photo-Oxidation of α-terpinene 1 to Ascaridole 2 and the Common Byproduct p-Cymene 3 Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory Darren S. Lee† , Zacharias Amara†, Charlotte A. Clark†, Zeyuan Xu‡, Bruce Kakimpa‡, Herve P. Morvan‡, Stephen J. Pickering‡, Martyn Poliakoff*†, and Michael W. George*†§ †School of Chemistry, ‡Department of Mechanical, Materials and Manufacturing Engineering, University of …
Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions
It’s only fair to share… Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions Green Chem., 2017, 19,2931-2935 DOI: 10.1039/C7GC00789B, Communication O. N. Chupakhin, A. V. Shchepochkin, V. N. Charushin A simple and efficient electrochemical method for the synthesis of asymmetrical bi(het)aryls through direct functionalization of the C(sp2)-H bond in …
Increasing global access to the high-volume HIV drug nevirapine through process intensification
It’s only fair to share… Increasing global access to the high-volume HIV drug nevirapine through process intensification Green Chem., 2017, 19,2986-2991 DOI: 10.1039/C7GC00937B, Paper Jenson Verghese, Caleb J. Kong, Daniel Rivalti, Eric C. Yu, Rudy Krack, Jesus Alcazar, Julie B. Manley, D. Tyler McQuade, Saeed Ahmad, Katherine Belecki, B. Frank Gupton Fundamental elements of process …
Cp2TiCl: An Ideal Reagent for Green Chemistry?
It’s only fair to share… The development of Green Chemistry inevitably involves the development of green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some of the 12 principles summarized for Green Chemistry, such as waste …