It’s only fair to share… BRD2879 BRD-K56962879-001-01-5 CAS 1304750-47-7 Chemical Formula: C30H38FN3O5S Molecular Weight: 571.7084 3-cyclohexyl-1-(((4R,5R)-8-((3-fluorophenyl)ethynyl)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea 3-cyclohexyl-1-[[(4R,5R)-8-[2-(3-fluorophenyl)ethynyl]-2-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-5-yl]methyl]-1-methylurea BRD2879 is a potent and cell-active inhibitor of IDH1-R132H with a markedly different structure from previously reported probes with (IC50 = 50 nM for inhibiting IDH1-R132H enzyme). BRD2879 represents a new structural class of mutant IDH1 inhibitors that, …
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PF 610355 Revisited
It’s only fair to share… PF-610355 Molecular Formula C34H39N3O6S Average mass 617.755 Da PF 610655, PF-00610355; PF-610,355 2-[3-[2-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methylsulfonylamino)phenyl]ethyl]amino]-2-methyl-propyl]phenyl]-N-[[3-(4-hydroxyphenyl)phenyl]methyl]ethanamide 862541-45-5 cas Originator Pfizer Class Antiasthmatics; Benzeneacetamides; Sulfonamides Mechanism of Action Beta 2 adrenergic receptor agonists Orphan Drug StatusNo On Fast trackNo Highest Development Phases Discontinued Asthma; Chronic obstructive pulmonary disease Most Recent Events 11 Aug 2011 Discontinued – Phase-I for Asthma in Belgium (Inhalation) …
Solifenacin, солифенацин , سوليفيناسين , 索利那新 , コハク酸ソリフェナシン
It’s only fair to share… SOLIFENACIN, YM-905 MF C23H26O2, a molecular weigt 362.4647 CAS 242478-37-1 солифенацин [Russian] سوليفيناسين [Arabic] 索利那新 [Chinese] 242478-37-1 (Solifenacin ) 242478-38-2 (Solifenacin Succinate) Solifenacin succinate, YM-67905 コハク酸ソリフェナシン Molecular Formula: C11H19NO7S Formula Weight: 480.56 CAS 242478-38-2 Usage Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence. Usage sedative Usage Solifenacin succinate is a urinary antispasmodic of the …
BMS-599793
It’s only fair to share… BMS-599793 (DS003, BMS-599793) Cas 676489-50-2 Molecular Formula: C27H22N6O3 Molecular Weight: 478.512 g/mol 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxo-acetyl]-4-piperidylidene]-2-phenyl-acetonitrile; 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetyl]piperidin-4-ylidene]-2-phenylacetonitrile; Piperidine, 4-(cyanophenylmethylene)-1-[2-(4-methoxy-7-pyrazinyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-; US 20040063744 , US 20040186292, WO 2009114313 Inventors Andrew S. Thompson, Hua Cheng, Stanislaw Pikul Applicant International Partnership For Microbicides Stanislaw Pikul 2-(1-(2-(4-methoxy-7-(pyrazin-2-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanoyl)piperidin-4- ylidene)-2-phenylethanenitrile 1 (DS003, BMS-599793) is a small molecule entry inhibitor that interferes with HIV infection by …
A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug
It’s only fair to share… PAPER HETEROCYCLES An International Journal for Reviews and Communications in Heterocyclic Chemistry Web Edition ISSN: 1881-0942 Published online: 11th October, 2016 Paper | Regular issue | Prepress DOI: 10.3987/COM-16-13538 ■ A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug Zhezhou Yang, Lin Zhang, Huirong …
Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer
It’s only fair to share… 4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile WILL BE UPDATED……… Prostate cancer, one of the most malignant tumors worldwide, is the second leading cause of cancer deaths among men in America . Although androgen deprivation therapy (ADT) has been proved to be effective initially, the tumor will eventually progress and develop into the lethal castration resistant …
BMS-741672
It’s only fair to share… BMS-741672 N-((1R,2S,5R)-5-(Isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide BMS-741672 N-((lR,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6- (trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-l-yl)cyclohexyl)acetamide N-((1R,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide; C25 H33 F3 N6 O2, 506.56 Acetamide, N-[(1R,2S,5R)-5-[methyl(1-methylethyl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)-4-quinazolinyl]amino]-1-pyrrolidinyl]cyclohexyl]- CAS 1004757-96-3 PHASE 2, , Treatment of Type 2 Diabetes, Agents for Neuropathic Pain Chemokine CCR2 (MCP-1 Receptor) Antagonists Molecular Formula: C25H33F3N6O2 Molecular Weight: 506.574 g/mol Michael G. Yang, Robert J. Cherney Original Assignee Bristol-Myers Squibb Company Michael G. Yang, …
Cetilistat, セチリスタット
It’s only fair to share… Cetilistat, セチリスタット Molecular FormulaC25H39NO3 Average mass401.582 Da CAS 282526-98-1 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one 282526-98-1 [RN] 2-Hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one 2-hexadecyl-oxy-6-methyl-4H-3,1-benzoxazin-4-one 4H-3,1-Benzoxazin-4-one, 2-(hexadecyloxy)-6-methyl [282526-98-1] 2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one ATL-962; ATL962;ATL 962 Trade Name：Oblean® MOA：Pancreatic lipase inhibitor Indication：Obesity Status：Approved, 2013-09-20 JAPAN, Japan PMDA. Company：Norgine (Originator) , Takeda Cetilistat was approved by Pharmaceuticals Medical Devices Agency of Japan (PMDA) on September 20, 2013. It was …
BMS-442608
It’s only fair to share… BMS-442608 8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6R)- (6R)-6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione (R)-6-Hydroxybuspirone, UNII-93881477KV, CAS 477930-30-6, Molecular Formula, C21-H31-N5-O3, Molecular Weight, 401.5079 BMS-442608 is a 5-HT1A partial agonist. BMS-442608 is the R-enantiomer. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer. (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the …
BMS-852927
It’s only fair to share… BMS-852927 CAS 256918-39-4 609.51 MW C29 H28 Cl2 F2 N2 O4 S MF 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol 1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-α,α-dimethyl- Treat metabolic syndrome Brett Busch, Ph.D. https://www.linkedin.com/in/brettbbusch Brett B. Busch, William C. Stevens, Jr., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu,Richard Martin, Raju Mohan Applicant Exelixis, Inc. Brett B. Busch, William C. Stevens, JR., …