Colfosceril miristate
CAS 18194-24-6
MF C36H72NO8P MW677.9325
1,2 Dimyristoyl glycero 3 phosphorylcholine
(2R)-2,3-bis(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
surfactant replacement, DIMYRISTOYL LECITHIN, Dimyristoyllecithin, DMCP, DMPC
Colfosceril miristate (1,2-dimyristoyl-sn-glycero-3-phosphocholine or DMPC) is a synthetic phospholipid commonly used in research to study lipid bilayers, liposomes, and drug delivery systems. It serves as a model membrane system due to its phase transition properties and has shown potential in enhancing nanoparticle uptake and acting as a drug stabilizer.
Key Aspects of Colfosceril Miristate (DMPC):
- Scientific Application: Primarily used in laboratory research for studying lipid monolayers and bilayers.
- Drug Delivery: Employed in the creation of liposomes for drug delivery applications.
- Biological Activity: Exhibits antiproliferative effects on various tumor cell lines and can increase the cellular uptake of nanoparticles.
- Characteristics: It is a synthetic phospholipid, frequently studied for its phase transition temperature (approx.
).
- Storage: Should be stored at
or
to maintain stability.
Important Distinction:
It is crucial not to confuse Colfosceril miristate (DMPC) with Colfosceril palmitate (DPPC). Colfosceril palmitate is a different synthetic surfactant historically used in medicine to treat neonatal respiratory distress syndrome
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (dimyristoyl phosphatidylcholine, DMPC) is a synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. DMPC is a frequently studied artificial lipid because it undergoes a phase transition at a convenient temperature. Upon cooling below 23.6°C it undergoes a transition from the liquid crystalline phase to the solid rippled phase, characterized by periodic corrugations of the bilayer.
Dimyristoylphosphatidylcholine is a phosphatidylcholine, a kind of phospholipid. Along with other lipids, it can be used to prepare liposomes.[1]
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| Names | |
|---|---|
| Systematic IUPAC name(2R)-2,3-Bis(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate | |
| Other names1,2-dimyristoylphosphatidylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine, DMPC, 14:0 PC | |
| Identifiers | |
| CAS Number | 18194-24-6 |
| 3D model (JSmol) | Interactive image |
| ChEBI | CHEBI:45240 |
| ChEMBL | ChEMBL1235508 |
| ChemSpider | 4573168 |
| ECHA InfoCard | 100.038.245 |
| EC Number | 242-085-9 |
| PubChem CID | 5459377 |
| UNII | 52QK2NZ2T0 |
| CompTox Dashboard (EPA) | DTXSID00860227 |
| InChI | |
| SMILES | |
| Properties | |
| Chemical formula | C36H72NO8P |
| Molar mass | 677.945 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).Infobox references | |
References
- Liposomal drug delivery system from laboratory to clinic, N. A. Kshirsagar, S. K. Pandya, G. B. Kirodian, S. Sanath, Journal of Postgraduate Medicine, 51 (#5) (2005), pp. 5-15, PMID 16519249.
//////////colfosceril miristate, ANAX LAB, surfactant replacement, DIMYRISTOYL LECITHIN, Dimyristoyllecithin, DMCP, DMPC