It’s only fair to share… Iptacopan 1644670-37-0 422.525, C25H30N2O4 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl) benzoic acid BENZOIC ACID, 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)-2-PIPERIDINYL)- Iptacopan LNP 023 LNP-023 LNP023 NVP-LNP023 NVP-LNP023-NX fda approved, To treat paroxysmal nocturnal hemoglobinuria, 12/5/2023, Fabhalta ‘CHINA 2024 ALSO Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) …
CAREBASTINE
It’s only fair to share… CAREBASTINE Molecular Weight 499.64 Appearance Solid Formula C32H37NO4 CAS No. 90729-42-3 Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor. Carebastine is the active metabolite …
VODOBATINIB
It’s only fair to share… VODOBATINIB 1388803-90-4 Molecular Weight 453.92 Appearance Solid Formula C27H20ClN3O2 SCO-088 K0706 K-0706 2-chloro-6-methyl-N‘-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic …
Etrasimod
It’s only fair to share… Etrasimod APD334 C26H26F3NO3 457.493 1206123-37-6 2-[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid Etrasimod arginine MXE5EMA09L 1206123-97-8 GVPVVOSNDUAUKM-BPGOJFKZSA-N Name: Etrasimod arginine CAS#: 1206123-97-8 (arginine) Chemical Formula: C32H40F3N5O5 Exact Mass: 631.30 Molecular Weight: 631.700 FDA APPROVED, To treat moderately to severely active ulcerative colitis in adults, 10/12/2023 Velsipity Etrasimod, sold under the brand name Velsipity, is a medication that …
Motixafortide
It’s only fair to share… Motixafortide 4F-benzoyl-TN-14003 BKT-140 BKT140 BL-8040 Protein Chemical FormulaC97H144FN33O19S2 Protein Average Weight2159.6 Da UNIIDA9G065962CAS number664334-36-5 >Motixafortide sequence RRXCYXKKPYRXCR Motixafortide acetate 2639893-42-6 GMUZYOKQKWMETH-AQDOTSTFSA-N fda approved,9/8/2023, Aphexda мотиксафортид [Russian] موتيكسافورتيد [Arabic] 莫替福肽 [Chinese] Motixafortide is a peptide inhibitor of CXCR4 used to mobilize hematopoietic stem cells prior to collection and autologous transplantation in multiple myeloma patients. …
Evobrutinib
It’s only fair to share… Evobrutinib 429.5 g/mol,C25H27N5O2 Evobrutinib 1415823-73-2 Evobrutinib [INN] 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one MSC2364447C MSC2364447C M-2951 MSC-2364447C ZA45457L1K 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one M2951 Evobrutinib is under investigation in clinical trial NCT03934502 (Effect of Meal Composition and Timing on Evobrutinib Bioavailability). Evobrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of …
Zuranolone
It’s only fair to share… Zuranolone CAS 1632051-40-1 Zurzuvae FDA APPROVED 8/4/2023, To treat postpartum depression Press Release WeightAverage: 409.574 Monoisotopic: 409.272927379Chemical FormulaC25H35N3O2 SAGE 217 SAGE-217 SAGE217 Zuranolone, sold under the brand name Zurzuvae, is a medication used for the treatment of postpartum depression.[1][2] It is taken by mouth.[1] The most common side effects include drowsiness, dizziness, diarrhea, fatigue, nasopharyngitis, and urinary tract infection.[1][2] An orally active inhibitory pregnane neurosteroid, zuranolone acts as a positive …
EIDD-2173, ATI-2173, Fosclevudine alafenamide
It’s only fair to share… EIDD-2173; also known as ATI-2173 Fosclevudine alafenamide Molecular Weight 529.45 Formula C22H29FN3O9P CAS No. 1951476-79-1 phase 2 Hepatitis B virus (HBV) is an infectious disease that targets the liver resulting in either an acute infection, with symptoms arising in 45 to 160 days, or a chronic infection, which 350 …
Palovarotene
It’s only fair to share… Palovarotene Sohonos CAS 410528-02-8 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid FDA 8/16/2023 To reduce the volume of new heterotopic ossification in adults and pediatric patients (aged 8 years and older for females and 10 years and older for males) with fibrodysplasia ossificans progressiva RG-667 RO-3300074 Palovarotene, sold under the brand name Sohonos, is a medication used for the treatment …
Zavegepant
It’s only fair to share… Zavegepant ザベジェパント; 1337918-83-8 as HCl: 1414976-20-7 C36H46N8O3 BASE 638.8 g/mol BASE Vazegepant BMS-742413 BHV-3500 FDA APPR 3/9/2023Zavzpret N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1H-quinolin-3-yl)piperidine-1-carboxamide ZAVZPRET is indicated for the acute treatment of migraine with or without aura in adults. The recommended dose of ZAVZPRET is 10 mg given as a single spray in one nostril, as needed. The …