Idecabtagene vicleucel

It’s only fair to share…   Idecabtagene vicleucel CAS 2306267-75-2 STN: BLA 125736 An autologous T lymphocyte-enriched cell transduced ex vivo with an anti-BCMA CAR lentiviral vector encoding a chimeric antigen receptor CAR, comprising a CD8 hinge and TM domain, 4-1BB costimulatory domain and CD3ζ signaling domain, targeting human B cell maturation antigen for cancer immunotherapy (Celgene …

Loncastuximab tesirine

It’s only fair to share…   Loncastuximab tesirine ZYNLONTA FDA APPROVED 2021/4/23 https://www.adcreview.com/wp-content/uploads/2019/06/15_ICML_Chiara-Tarantelli-ADCT_402_preclinical.pdf Formula C6544H10048N1718O2064S52 Exact mass 147387.9585 CAS 1879918-31-6 Efficacy Antineoplasitc, Anti-CD19 antibody   Disease Diffuse large B-cell lymphoma not otherwise specified [DS:H02434] Comment Antibody-drug conjugate Treatment of hematological cancers ロンカスツキシマブテシリン; ADCT-402, ADCX 19 Immunoglobulin G1, anti-(human CD19 antigen) (human-Mus musculus monoclonal RB4v1.2 γ1-chain), disulfide with human-Mus …

ZyCoV-D

It’s only fair to share… ZyCoV-D CAS 2541524-47-2 DNA vaccine construct encoding a spike protein antigen of SARS-CoV-2 virus (Zydus-Cadila) https://zyduscadila.com/public/pdf/Covid%2019_Booklet_9th%20FEB_FINAL.pdf http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=51254&EncHid=&userName=ZyCoV-D bioRxiv (2021), 1-26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423510/ ZyCoV-D | (CTRI/2020/07/026352, 2020, CTRI/2020/07/026352, 2020; Myupchar, 2020) ZYDUS CADILA ZyCoV-D is a genetically engineered DNA plasmid based vaccine encoding for the membrane proteins of the virus. The clinical trials to study the immunogenicity, …

Dostarlimab

It’s only fair to share… (Heavy chain) EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYDMSWVRQA PGKGLEWVST ISGGGSYTYY QDSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCASPY YAMDYWGQGT TVTVSSASTK GPSVFPLAPC SRSTSESTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS LSSVVTVPSS SLGTKTYTCN VDHKPSNTKV DKRVESKYGP PCPPCPAPEF LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSQEDPEVQ FNWYVDGVEV HNAKTKPREE QFNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKGLPSSIEK TISKAKGQPR EPQVYTLPPS QEEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSRLTVDK SRWQEGNVFS CSVMHEALHN HYTQKSLSLS LGK (Light chain) DIQLTQSPSF …

2-Deoxy-D-glucose

It’s only fair to share… 2-Deoxy-D-glucose Molecular FormulaC6H12O5 Average mass164.156 Da 2-Deoxy-D-glucose (4R,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol (4R,5S,6R)-6-(Hydroxyméthyl)tétrahydro-2H-pyran-2,4,5-triol 154-17-6 [RN] 2-Deoxy-D-arabino-hexopyranose 2-deoxy-D-glucopyranose 2-deoxyglucose 2-DG D-arabino-2-Desoxyhexose D-arabino-Hexopyranose, 2-deoxy- [ (4R,5S,6R)-6-(Hydroxymethyl)oxane-2,4,5-triol 2-deoxyglucopyranose 2-deoxymannopyranose 2-dGlc 61-58-5 [RN] 77252-38-1 [RN] D-arabino-2-Deoxyhexose glucitol, 2,5-anhydro- 2-Deoxy-D-arabino-hexose 2 DG 2-Deoxy-D-glucose 2-Deoxy-D-mannose 2-Deoxyglucose 2-Desoxy-D-glucose Ba 2758 D-Glucose, 2-deoxy- NSC 15193 2-Deoxy-D-glucose CAS Registry Number: 154-17-6 CAS Name: 2-Deoxy-D-arabino-hexose Additional Names: D-arabino-2-desoxyhexose; 2-deoxyglucose; 2-DG Manufacturers’ …

Ramatroban

It’s only fair to share… Ramatroban   Formula C21H21FN2O4S  CAS  116649-85-5 Mol weight 416.4658   (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (+)-(3R)-3-(p-fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid; (+)-3-(4-fluorophenylsulfonamido)-9-(2-carboxyethyl)-1,2,3,4-tetrahydrocarbazole 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid Manufacturers’ Codes: Bay u 3405 3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid BAY u 3405 BAY u 3406 BAY u-3405 BAY u3405 ramatroban Trademarks: Baynas (Bayer) MF: C21H21FN2O4S MW: 416.47 Percent Composition: C 60.56%, H 5.08%, F …

Pegylated Interferon alpha-2b, (PegIFN), Virafin

It’s only fair to share… DB00022 sequence CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMI QQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVR KYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE   CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Chemical structure of peginterferon α-2a and α-2b. Abbreviations: PeG-IFN, peginterferon; IFN, interferon; Lys, lysine; His, histidine; Cys, cysteine; Ser, serine. Pegylated Interferon alpha-2b (PegIFN), Virafin Formula C860H1353N229O255S9 …

DEXMETHYLPHENIDATE

It’s only fair to share… DEXMETHYLPHENIDATE SynonymsDexmethylphenidate HCl, UNII1678OK0E08, CAS Number19262-68-1, WeightAverage: 269.77 Chemical FormulaC14H20ClNO2 methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate hydrochloride CAS Number 40431-64-9  as HCl: 19262-68-1 PubChem CID 154101 as HCl: 154100 IUPHAR/BPS 7554 DrugBank DB06701  as HCl: DBSALT001458 ChemSpider 135807  as HCl: 135806 UNII M32RH9MFGP as HCl: 1678OK0E08 Trade Name:Focalin® / Attenade®MOA:Norepinephrine-dopamine reuptake inhibitorIndication:Attention deficit hyperactivity disorder (ADHD)Status:ApprovedCompany:Novartis (Originator) , CelgeneSales:$365 Million (Y2015);  $492 Million …

Serdexmethylphenidate

It’s only fair to share… Serdexmethylphenidate Molecular FormulaC25H30ClN3O8 Average mass535.974 Da CAS 1996626-30-2      L-Serine, N-[[1-[[[[(2R)-2-[(1R)-2-methoxy-2-oxo-1-phenylethyl]-1-piperidinyl]carbonyl]oxy]methyl]-3-pyridiniumyl]carbonyl]-, chloride (1:1) N-[(1-{[({(2R)-2-[(1R)-2-Methoxy-2-oxo-1-phenylethyl]-1-piperidinyl}carbonyl)oxy]methyl}-3-pyridiniumyl)carbonyl]-L-serine chloride Azstarys, FDA APPROVED, 3/2/2021, Products on NDA 212994, Type 1 – New Molecular Entity and Type 4 – New Combination Serdexmethylphenidate Chloride (SDX), SDX or KP145 https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212994s000lbl.pdf   Molecular Formula C25H30ClN3O8 Synonyms UNII-FN54BT298Y KP415 Cl Serdexmethylphenidate chloride FN54BT298Y …

Sacituzumab govitecan-hziy

It’s only fair to share…   Sacituzumab govitecan-hziy 1601.8 g/mol C76H104N12O24S (2R)-2-amino-3-[1-[[4-[[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-[2-[[(2S)-6-amino-1-[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxycarbonyloxymethyl]anilino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoyl]cyclohexyl]methyl]-2,5-dioxopyrrolidin-3-yl]sulfanylpropanoic acid Trodelvy  hRS 7SN38 hRS7-SN38 IMMU 132 IMMU-132 CAS: 1491917-83-9 M9BYU8XDQ6 EX-A4354 UNII-DA64T2C2IO component ULRUOUDIQPERIJ-PQURJYPBSA-N UNII-SZB83O1W42 component ULRUOUDIQPERIJ-PQURJYPBSA-N Efficacy Antineoplastic, Topoisomerase I inhibitor   Disease Breast cancer (triple negative) Sacituzumab Govitecan is an antibody drug conjugate containing the humanized monoclonal antibody, hRS7, against tumor-associated calcium signal transducer …