Tag «2020 APPROVALS»

Melatonin

It’s only fair to share…   Melatonin メラトニン Formula C13H16N2O2 CAS73-31-4 73-31-4 Mol weight 232.2783 APPROVED, Melatobel, JAPAN 2020/3/25 200-659-6 [EINECS] 200-797-7 [EINECS] 205542 [Beilstein] 73-31-4 [RN] Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-Acetamide Melatonin CAS Registry Number: 73-31-4 CAS Name: N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide Additional Names: N-acetyl-5-methoxytryptamine Trademarks: Regulin (Young) Molecular Formula: C13H16N2O2 Molecular Weight: 232.28 Percent Composition: C 67.22%, H 6.94%, N 12.06%, O 13.78% Literature References: A hormone of the pineal gland, also …

Borofalan (10B)

It’s only fair to share…   Borofalan (10B), ボロファラン (10B), 硼[10B]法仑 APPROVED JAPAN, 2020/3/25, Steboronine Antineoplastic, Diagnostic aid, Radioactive agent (2S)-2-amino-3-(4-(10B)dihydroxy(10B)phenyl)propanoic acid Formula C9H12BNO4 CAS 80994-59-8 Mol weight 209.0069 4-(Borono-10B)-L-phenylalanine (10B)-4-Borono-L-phenylalanine Borofalan (10b) L-(p-[10B]Boronophenyl)alanine L-4-[10B]Boronophenylalanine p-[10B]Borono-L-phenylalanine L-Phenylalanine, 4-borono-10B- Marketed Head and neck cancer Originator Stella Pharma Developer Osaka University; Stella Pharma; Sumitomo Heavy Industries Class Antineoplastics; Borates; Propionic acids; Radiopharmaceuticals Mechanism of Action Ionising …

Tepotinib hydrochloride

It’s only fair to share…   Tepotinib hydrochloride CS-977;Tepotinib;Veledimex;MSC2156119;EMD-1214063 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile;hydrate;hydrochloride Benzonitrile, 3-(1,6-dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo-3-pyridazinyl)-, hydrochloride, hydrate 3- (1- {3- [5- (1-methylpiperidin-4-ylmethoxy) pyrimidine) -2-yl] -benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl) -benzonitrile тепотиниб [Russian] [INN] تيبوتينيب [Arabic] [INN] 特泊替尼 [Chinese] [INN] 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile 3-{1-[(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazin-3-yl}benzonitrile EMD 1214063 MSC 2156119 Formula C29H28N6O2. HCl. H2O C29H28N6O2FREE CAS 1946826-82-9 HCL.H2O CAS No. FREE 1100598-32-0 Mol weight 547.0478 492.57 FREE JAPAN 25/3 2020 APPROVED, Tepmetko Antineoplastic, …

Tirabrutinib

It’s only fair to share… Tirabrutinib チラブルチニブ塩酸塩 GS-4059 ONO-4059 6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one Formula C25H22N6O3. HCl CAS 1439901-97-9 HCL 1351636-18-4FREE FORM Mol weight 490.9415 JAPAN APPROVED 2020/3/25 Velexbru Antineoplastic, Bruton’s tyrosine kinase inhibitor 8H-Purin-8-one,6-amino-7,9-dihydro-9-((3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl) 6-Amino-9-((3R)-1-(2-butynoyl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one Tirabrutinib (Velexbru®) is an orally administered, small molecule, Bruton’s tyrosine kinase (BTK) inhibitor being developed by Ono Pharmaceutical and its licensee Gilead Sciences for …

Pemigatinib

It’s only fair to share…   Pemigatinib INCB054828 Formula C24H27F2N5O4 CAS 1513857-77-6 2379919-96-5  HCL Mol weight 487.4991 2020/4/17FDA APPROVED, PEMAZYRE 佩米替尼 [Chinese] [INN] 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one 2H-Pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)- 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one OriginatorIncyte Corporation DeveloperIncyte Corporation; Innovent Biologics ClassAntineoplastics; Ethers; Fluorobenzenes; Morpholines; Pyridines; Pyrimidinones; Pyrroles; Small molecules Mechanism of ActionType 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor …

Ripretinib

It’s only fair to share… Ripretinib リプレチニブ; Formula C24H21BrFN5O2 CAS 1442472-39-0 Mol weight 510.3582 Antineoplastic, Receptor tyrosine kinase inhibitor US FDA APPROVED 2020/5/15 QUINLOCK NAME DOSAGE STRENGTH ROUTE LABELLER MARKETING START MARKETING END Qinlock Tablet 50 mg Oral Deciphera Pharmaceuticals. Llc Not applicable Not applicable Qinlock Tablet 50 mg/1 Oral Deciphera Pharmaceuticals, LLC 2020-05-15 Not applicable …

Triheptanoin

It’s only fair to share…   Triheptanoin Approved US FDA 30/6/2020 Dojolvi UX 007 Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.4 In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, …

Enarodustat

It’s only fair to share…   Enarodustat エナロデュスタット JTZ 951 Formula C17H16N4O4 CAS 1262132-81-9 Mol weight 340.3333 PMDA 2020/9/25 APPROVED ENAROY Anti-anemic, Hypoxia inducible factor-prolyl hydroxylase (HIF-PH) inhibitor Originator Japan Tobacco Developer Japan Tobacco; JW Pharmaceutical Class Acetic acids; Amides; Antianaemics; Pyridones; Small molecules; Triazoles Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors Preregistration Anaemia 27 Dec …

Sofpironium bromide ソフピロニウム臭化物

It’s only fair to share… Sofpironium bromide ソフピロニウム臭化物 BBI 4000 [(3R)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Formula C22H32NO5. Br CAS 1628106-94-4 BASE 1628251-49-9 Mol weight 470.3972 PMDA APPROVED JAPAN 2020/9/25, Ecclock Anhidrotic Sofpironium Bromide 1-ambo-(3R)-3-{[(R)-(Cyclopentyl)hydroxy(phenyl)acetyl]oxy}-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidinium bromide C22H32BrNO5 : 470.4 [1628106-94-4] SYN PATENT WO 2018026869 https://patents.google.com/patent/WO2018026869A1/en Certain glycopyrronium salts and related compounds, as well as processes for making and methods of using these glycopyrronium salts and …

Abametapir アバメタピル , абаметапир , أباميتابير , 阿巴甲吡 ,

It’s only fair to share…   Abametapir アバアバメタピル , абаметапир , أباميتابير , 阿巴甲吡 , 5,5′-dimethyl-2,2′-bipyridine, 6,6′-Bi-3-picoline BRN 0123183 HA 44 HA-44 HA44 Formula C12H12N2 CAS 1762-34-1 Mol weight 184.2371 Xeglyze, FD APPROVED 24/7/2020 Pediculicide, Metalloproteinase inhibitor   Disease Head lice infestation Originator Hatchtech DeveloperDr Reddys Laboratories; Hatchtech ClassAntiparasitics; Heterocyclic compounds; Pyridines; Small molecules Mechanism of ActionChelating agents; Metalloprotease inhibitors Registered Pediculosis 27 Jul …