It’s only fair to share… Samidorphan サミドルファン; Formula C21H26N2O4 CAS 852626-89-2 Mol weight 370.4421 FDA APPROVED 5/28/2021 Lybalvi ALKS 33 ALKS-33 RDC-0313 RDC-0313-00 Product Ingredients UNII0AJQ5N56E0 CAS Number1204592-75-5 WeightAverage: 504.536 Monoisotopic: 504.210780618 Chemical FormulaC25H32N2O9 INGREDIENT UNII CAS INCHI KEY Samidorphan L-malate 0AJQ5N56E0 1204592-75-5 RARHXUAUPNYAJF-QSYGGRRVSA-N IUPAC Name (1R,9R,10S)-17-(cyclopropylmethyl)-3,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2,4,6-triene-4-carboxamide; (2S)-2-hydroxybutanedioic acid MOA：mu-Opioid antagonist; delta-Opioid partial agonist; kappa-Opioid partial agonistsIndication：Alcohol …
Tag «APPROVALS 2021»
Piflufolastat F 18 injection, Dcfpyl F-18
It’s only fair to share… Piflufolastat F 18 injection Dcfpyl F-18 CAS 207181-29-0 PLAIN F 1423758-00-2 WITHOUT RADIO LABEL C18 H23 F N4 O8, 441.4 L-Glutamic acid, N-[[[(1S)-1-carboxy-5-[[[6-(fluoro-18F)-3-pyridinyl]carbonyl]amino]pentyl]amino]carbonyl]- 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl) amino]-pentyl}ureido)-pentanedioic acid Other Names N-[[[(1S)-1-Carboxy-5-[[[6-(fluoro-18F)-3-pyridinyl]carbonyl]amino]pentyl]amino]carbonyl]-L-glutamic acid [18F]DCFPyl Dcfpyl F-18 (18F)Dcfpyl UNII-3934EF02T7 18F-DCFPyL 3934EF02T7 Progenics Pharmaceuticals, Inc. APPROVED 5/26/2021 fda, Pylarify For positron emission tomography imaging of prostate-specific membrane antigen-positive lesions in men with prostate …
Amivantamab
It’s only fair to share… (A chain) QVQLVESGGG VVQPGRSLRL SCAASGFTFS TYGMHWVRQA PGKGLEWVAV IWDDGSYKYY GDSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARDG ITMVRGVMKD YFDYWGQGTL VTVSSASTKG PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KRVEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFLLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK (B chain) …
Sotorasib
It’s only fair to share… Sotorasib 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one AMG 510 AMG-510 AMG510 Formula C30H30F2N6O3 CAS 2296729-00-3 Mol weight 560.5944 FDA APPROVED, 2021/5/28 Lumakras Antineoplastic, Non-small cell lung cancer (KRAS G12C-mutated) ソトラシブ (JAN); 2296729-00-3 (racemate) 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one Sotorasib [INN] 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one Sotorasib (1M)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one C30H30F2N6O3 : 560.59 [2296729-00-3] Sotorasib is an inhibitor of the RAS GTPase family. The molecular formula is C30H30F2N6O3, and the …
Idecabtagene vicleucel
It’s only fair to share… Idecabtagene vicleucel CAS 2306267-75-2 STN: BLA 125736 An autologous T lymphocyte-enriched cell transduced ex vivo with an anti-BCMA CAR lentiviral vector encoding a chimeric antigen receptor CAR, comprising a CD8 hinge and TM domain, 4-1BB costimulatory domain and CD3ζ signaling domain, targeting human B cell maturation antigen for cancer immunotherapy (Celgene …
Loncastuximab tesirine
It’s only fair to share… Loncastuximab tesirine ZYNLONTA FDA APPROVED 2021/4/23 https://www.adcreview.com/wp-content/uploads/2019/06/15_ICML_Chiara-Tarantelli-ADCT_402_preclinical.pdf Formula C6544H10048N1718O2064S52 Exact mass 147387.9585 CAS 1879918-31-6 Efficacy Antineoplasitc, Anti-CD19 antibody Disease Diffuse large B-cell lymphoma not otherwise specified [DS:H02434] Comment Antibody-drug conjugate Treatment of hematological cancers ロンカスツキシマブテシリン; ADCT-402, ADCX 19 Immunoglobulin G1, anti-(human CD19 antigen) (human-Mus musculus monoclonal RB4v1.2 γ1-chain), disulfide with human-Mus …
ZyCoV-D
It’s only fair to share… ZyCoV-D CAS 2541524-47-2 DNA vaccine construct encoding a spike protein antigen of SARS-CoV-2 virus (Zydus-Cadila) https://zyduscadila.com/public/pdf/Covid%2019_Booklet_9th%20FEB_FINAL.pdf http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=51254&EncHid=&userName=ZyCoV-D bioRxiv (2021), 1-26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423510/ ZyCoV-D | (CTRI/2020/07/026352, 2020, CTRI/2020/07/026352, 2020; Myupchar, 2020) ZYDUS CADILA ZyCoV-D is a genetically engineered DNA plasmid based vaccine encoding for the membrane proteins of the virus. The clinical trials to study the immunogenicity, …
Pegylated Interferon alpha-2b, (PegIFN), Virafin
It’s only fair to share… DB00022 sequence CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMI QQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVR KYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Chemical structure of peginterferon α-2a and α-2b. Abbreviations: PeG-IFN, peginterferon; IFN, interferon; Lys, lysine; His, histidine; Cys, cysteine; Ser, serine. Pegylated Interferon alpha-2b (PegIFN), Virafin Formula C860H1353N229O255S9 …
DEXMETHYLPHENIDATE
It’s only fair to share… DEXMETHYLPHENIDATE SynonymsDexmethylphenidate HCl, UNII1678OK0E08, CAS Number19262-68-1, WeightAverage: 269.77 Chemical FormulaC14H20ClNO2 methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate hydrochloride CAS Number 40431-64-9 as HCl: 19262-68-1 PubChem CID 154101 as HCl: 154100 IUPHAR/BPS 7554 DrugBank DB06701 as HCl: DBSALT001458 ChemSpider 135807 as HCl: 135806 UNII M32RH9MFGP as HCl: 1678OK0E08 Trade Name：Focalin® / Attenade®MOA：Norepinephrine-dopamine reuptake inhibitorIndication：Attention deficit hyperactivity disorder (ADHD)Status：ApprovedCompany：Novartis (Originator) , CelgeneSales：$365 Million (Y2015); $492 Million …
Sacituzumab govitecan-hziy
It’s only fair to share… Sacituzumab govitecan-hziy 1601.8 g/mol C76H104N12O24S (2R)-2-amino-3-[1-[[4-[[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-[2-[[(2S)-6-amino-1-[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxycarbonyloxymethyl]anilino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoyl]cyclohexyl]methyl]-2,5-dioxopyrrolidin-3-yl]sulfanylpropanoic acid Trodelvy hRS 7SN38 hRS7-SN38 IMMU 132 IMMU-132 CAS: 1491917-83-9 M9BYU8XDQ6 EX-A4354 UNII-DA64T2C2IO component ULRUOUDIQPERIJ-PQURJYPBSA-N UNII-SZB83O1W42 component ULRUOUDIQPERIJ-PQURJYPBSA-N Efficacy Antineoplastic, Topoisomerase I inhibitor Disease Breast cancer (triple negative) Sacituzumab Govitecan is an antibody drug conjugate containing the humanized monoclonal antibody, hRS7, against tumor-associated calcium signal transducer …