Tag «enzalutamide»

ENZALUTAMIDE

It’s only fair to share…   4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile Drug Name: Enzalutamide Research Code: MDV-3100 Trade Name: Xtandi® MOA: Androgen receptor inhibitor Indication: Prostate cancer Status: Approved Company: Medivation (Originator) , Astellas Sales: $2,100.8 Million (Y2015);  $1,247.3 Million (Y2014); $546 Million (Y2013); $148.8 Million (Y2012); ATC Code: L01 Approved Countries or AreaUpdate Date:2015-07-29  US EU JP Approval …

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

It’s only fair to share… 4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile WILL BE UPDATED……… Prostate cancer, one of the most malignant tumors worldwide, is the second leading cause of cancer deaths among men in America . Although androgen deprivation therapy (ADT) has been proved to be effective initially, the tumor will eventually progress and develop into the lethal castration resistant …