Category «synthesis»

Is water a suitable solvent for the catalytic amination of alcohols?

It’s only fair to share… Is water a suitable solvent for the catalytic amination of alcohols? Green Chem., 2017, 19,2839-2845 DOI: 10.1039/C7GC00422B, Paper Johannes Niemeier, Rebecca V. Engel, Marcus Rose The catalytic aqueous-phase amination of biogenic alcohols with solid catalysts is reported for future development of renewable amine value-added chains. From the journal: Green Chemistry …

Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature

It’s only fair to share… Fe/ppm Cu nanoparticles as a recyclable catalyst for click reactions in water at room temperature Green Chem., 2017, 19,2506-2509 DOI: 10.1039/C7GC00883J, Communication Aurelien Adenot, Evan B. Landstrom, Fabrice Gallou, Bruce H. Lipshutz Nanomicelles housing a terminal alkyne and azide are delivered to ppm Cu-containing nanoparticles that catalyse click reactions in …

Dr. Vinayak Pagar( GUEST BLOGGER) Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds

It’s only fair to share… Discussing my paper…….. Metal-catalyzed cycloadditions of alkenyldiazo reagents are useful tools to access carbo- and heterocycles.[1] These diazo compounds are chemically sensitive toward both Brønsted orLewis acids. Their reported cycloadditions rely heavily on the formation of metal carbenes to initiate regio- and stereoselective [3+n] cycloadditions (n=2–4) with suitable dipolarophiles.[2–4] A noncarbene route was postulated for a …

The greening of peptide synthesis

It’s only fair to share…   The greening of peptide synthesis Stefan B. Lawrenson,a  Roy Arava  and  Michael North*a  *Corresponding authors aGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, York, UK E-mail: Michael.north@york.ac.uk Abstract The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundamental part of …

New paper on Trelagliptin succinate

It’s only fair to share… Trelagliptin succinate, a novel once-weekly oral dipeptidyl peptidase-4 (DPP-4) inhibitor, was approved for the Japanese market on March 26, 2015 Trelagliptin exhibited a better potency against human DPP-4 than alogliptin and sitagliptin, along with its excellent selectivity and slow-binding properties that may partially contribute to its sustained efficacy. In phase III …

Regioselective access of alkylidendibenzo[c,f]oxocine framework via cyclocarbopalladation/cross-coupling cascade reactions and reductive Heck strategy

It’s only fair to share… Regioselective access of alkylidendibenzo[c,f]oxocine framework via cyclocarbopalladation/cross-coupling cascade reactions and reductive Heck strategy New J. Chem., 2017, Advance Article DOI: 10.1039/C6NJ03825E, Paper Tapas Ghosha   a Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany E-mail: tapas.ghosh@uni-wuerzburg.de,tapasghosh.chem@gmail.com Tel: +49-931-31-81629 New J. Chem., 2017, Advance Article DOI: 10.1039/C6NJ03825E Palladium-catalyzed …

Asymmetric total synthesis of (-)-δ-lycorane

It’s only fair to share… 1H NMR 13C NMR Org. Chem. Front., 2017, Advance Article DOI: 10.1039/C7QO00021A, Research Article Junliang Wang, Jianneng Li, Xianwang Shen, Cong Dong, Jun Lin, Kun Wei A first asymmetric synthesis of (-)-δ-lycorane by using a chiral bifunctional squaramide-catalysed cascade reaction is reported. Asymmetric total synthesis of (−)-δ-lycorane Junliang Wang,ab   Jianneng …

4-Pentenoic acid, 5-(3,4-methylenedioxyphenyl)-3-oxo-, ethyl ester

It’s only fair to share… 4-Pentenoic acid, 5-(3,4-methylenedioxyphenyl)-3-oxo-, ethyl ester cas 860547-52-0 MF C14 H14 O5 4-Pentenoic acid, 5-(1,3-benzodioxol-5-yl)-3-oxo-, ethyl ester Molecular Weight, 262.26 Melting Point (Experimental) Value: 58-60 °C Purification of the residue by flash column chromatography (10% ethyl acetate in hexanes) afforded the β-keto ester (12.0 g, 90%) as a pale yellow oil. …

(5-Chloro-2-methoxyphenyl)[3-fluoro-5-(trifluoromethyl)phenyl]methanone

It’s only fair to share… Cas 329941-92-6 C15 H9 Cl F4 O2 Methanone, (5-chloro-2-methoxyphenyl)[3-fluoro-5-(trifluoromethyl)phenyl]- (5-Chloro-2-methoxyphenyl)[3-fluoro-5-(trifluoromethyl)phenyl]methanone (7) 7 as white crystals mp 93–95 °C; 1H NMR (500 MHz, CDCl3) 7.82 (s, 1H), 7.66 (d, J = 8.5 Hz, 1H), 7.53 (d, J =7.5 Hz, 1H), 7.49 (d, J = 9.0 Hz, 1H), 7.42 (s, 1H), 6.97 (d, …