It’s only fair to share… Ateganosine CAS 789-61-7 MF C10H13N5O3S MW 283.31 g/mol 2′-deoxy-6-thioguanosinenucleoside analogue, antineoplastic Ateganosine is a telomerase inhibitor[1] and apoptosis inducer currently under investigation for the treatment of various cancers, including non-small cell lung cancer (NSCLC).[2] Beta-Thioguanine Deoxyriboside is a thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This …
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Bimokalner
It’s only fair to share… Bimokalner CAS 2243284-19-5 MF C15H18F5NOS MW 355.4 g/mol (1S,2S,4R)-N-{[3-(pentafluoro-λ6sulfanyl)phenyl]methyl} bicyclo[2.2.1]heptane-2-carboxamidevoltage-gated potassium channel (Kv7.4) agonist Bimokalner is an investigational new drug under evaluation for preventing and treating hearing loss caused by cisplatin treatment. It is a voltage-gated potassium channel agonist targeting Kv7.4 and is being developed by Acousia Therapeutics GmbH.[1][2] PAT Compounds useful as potassium channel openers, Publication Number: US-11884642-B2, Priority Date: 2017-02-28, Grant Date: 2024-01-30 …
Asengeprast
It’s only fair to share… Asengeprast CAS 1001288-58-9 FT011, FT 011, orphan drug status, systemic sclerosis, SHP-627, SHP 627, Fast Track 2-[[(E)-3-(3-methoxy-4-prop-2-ynoxyphenyl)prop-2-enoyl]amino]benzoic acid 2-[(2E)-3-{3-methoxy-4-[(prop-2-yn-1-yl)oxy]phenyl}prop-2-enamido]benzoic acid G protein-coupled receptor 68 (GPR68) antagonist,anti-inflammatory MF C20H17NO5 MW 351.4 g/mol. C6V7ZU2NPR Asengeprast (development code FT011) is an experimental scleroderma drug candidate.[1] It is a small molecule inhibitor of the G-protein coupled receptor GPR68 with antifibrotic activity.[2] It is …
Asandeutertinib
It’s only fair to share… Asandeutertinib, Osimertinib-d3 CAS 1638281-46-5 N-[2-{2-(dimethylamino)ethylamino}-4-methoxy-5-({4-[1-(2H3)methyl-1H-indol-3-yl]pyrimidin-2-yl}amino)phenyl]prop-2-enamideepidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, antineoplastic MF C28H30. 2H3. N7O2, C28H30D3N7O2 MW 502.6 g/mol Asandeutertinib is an investigational new drug that is being evaluated for the treatment of cancer. It is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with antineoplastic properties.[1][2] Developed by TYK Medicines, this small molecule drug is currently …
Admilparant
It’s only fair to share… Admilparant, (BMS-986278) CAS 2170126-74-4 MF C22H31N5O5 MW 445.5 g/mol (1S,3S)-3-({2-methyl-6-[1-methyl-5-({[methyl(propyl)carbamoyl]oxy}methyl)-1H-1,2,3-triazol-4-l]pyridin-3-yl}oxy)cyclohexane-1-carboxylic acidlysophosphatidic acid receptor 1 (LPA1) antagonist Admilparant is an investigational new drug being developed by Bristol-Myers Squibb for the treatment of idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). It is a first-in-class lysophosphatidic acid receptor 1 (LPA1) antagonist.[1][2] As of 2024, admilparant is in Phase III clinical trials …
Fexuprazan, Abeprazan
It’s only fair to share… Fexuprazan, Abeprazan; DWP14012; DWP-14012 1-[5-(2,4-difluorophenyl)-1-(3-fluorophenyl)sulfonyl-4-methoxypyrrol-3-yl]-N-methylmethanamine WeightAverage: 410.41Monoisotopic: 410.091198078 Chemical FormulaC19H17F3N2O3S Fexuprazan (trade name Fexuclue) is a drug for the treatment of gastroesophageal reflux disease (GERD).[1] It is a potassium-competitive acid blocker,[2] which is a class of drugs suppressing gastric acids.[3][4] Fexuprazan is approved for clinical use in South Korea,[4][5] Mexico,[6] Philippines,[7] Chile,[8] and Ecuador.[9] Abeprazan is under investigation in clinical trial …
Atigliflozin
It’s only fair to share… Atigliflozin CAS 647834-15-9 Chemical Formula: C18H22O7S Exact Mass: 382.1086 Molecular Weight: 382.43 AVE 2268; AVE-2268; AVE2268; Y0H7UPE4WJ (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-((2-(4-methoxybenzyl)thiophen-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. …
Abarelix
It’s only fair to share… Abarelix CAS 183552-38-7 785804-17-3 (acetate) 183552-38-7 (free base) PPI149, PPI-149, PPI 149, R3827, R-3827, R 3827, Abarelix, Abarelix acetate, Plenaxis, W486SJ5824 Chemical Formula: C72H95ClN14O14 Exact Mass: 1414.6841 Molecular Weight: 1416.06 Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Nalpha-Me-Tyr]-D-Asn-Leu-ILys-Pro-DAla-NH2 (2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide (2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks …
Rongliflozin, Olorigliflozin
It’s only fair to share… Rongliflozin Olorigliflozin, 6FP3NST6ZQ, DJT1116PG Cas 2035989-50-3 450.9 g/mol, C23H27ClO7 (1R,2S,3S,4R,5S)-5-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-[(1R)-1-hydroxyethyl]-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol Rongliflozin 화학구조 CAS No. : 2648020-91-9 MW 602.55 MF C23H27ClO7.C5H7NO3.5/4H2O Rongliflozin is an SGLT2 inhibitor developed as a potential treatment for diabetes.[1][2] Rongliflozin (DJT1116PG) is a selective and orally active inhibitor of sodium-glucose co-transporter-2 (SGLT-2). Rongliflozin can be used for the research of type 2 diabetes mellitus …
Mizagliflozin
It’s only fair to share… Mizagliflozin WeightAverage: 564.68Monoisotopic: 564.315914393 Chemical FormulaC28H44N4O8 2,2-dimethyl-3-[3-[3-methyl-4-[[5-propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenoxy]propylamino]propanamide Mizagliflozin is an SGLT1 inhibitor developed as a potential treatment for chronic constipation.[1][2] It progressed as far as Phase II trials in humans but was not approved for medical use, however it has since been investigated for other applications.[3][4] MIZAGLIFLOZIN is a small molecule drug with a maximum …