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Darifenacin Hydrobromide, 臭化水素酸ダリフェナシン

Darifenacin 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide Darifenacin; Emselex; Enablex; CAS 133099-04-4; UNII-APG9819VLM; US 2004-12-22 APPROVED EU 2004-10-22 APPROVED Molecular Formula: C28H30N2O2 Molecular Weight: 426.56 g/mol Title: Darifenacin CAS Registry Number: 133099-04-4 CAS Name: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a,a-diphenyl-3-pyrrolidineacetamide Additional Names: 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine; (S)-2-[1-[2-(2,3,-dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide Manufacturers’ Codes: UK-88525 Molecular Formula: C28H30N2O2 Molecular Weight: 426.55 Percent Composition: C 78.84%, H 7.09%, N 6.57%, O 7.50% Literature References: Selective muscarinic …

MK 0633, SETILEUTON

MK 0633, SETILEUTON (-)-enantiomer 910656-27-8 CAS free form MW 463.3817, C22 H17 F4 N3 O4 FREE FORM Tosylate cas 1137737-87-1 2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]- 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one WO2006099735A1 Inventors Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor WO 2006099735 A1Marc Blouin, Erich L. Grimm, Yves Gareau, Marc Gagnon, Helene Juteau, Sebastien Laliberte, Bruce Mackay, Richard Friesen, Applicant Merck …

Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts

Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts Green Chem., 2017, 19,809-815 DOI: 10.1039/C6GC03141B, Paper Haigen Huang, Xueguang Wang, Xu Li, Chenju Chen, Xiujing Zou, Weizhong Ding, Xionggang Lu A non-noble Ni-MoO3/CN@SBA-15 catalyst exhibits unprecedented catalytic activity and chemoselectivity for the reduction of nitroarenes to anilines in ethanol with hydrazine hydrate. Highly …

Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03494B, Paper Zheng Fang, Wen-Li Hu, De-Yong Liu, Chu-Yi Yu, Xiang-Guo Hu A procedure for the synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions has been developed. Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature …

Photobiocatalytic alcohol oxidation using LED light sources

Photobiocatalytic alcohol oxidation using LED light sources Oxidative lactonization of meso-3-methyl-1,5-pentanediol to (S)-4-methyltetrahydro-2H-pyran-2-one using horse liver alcohol dehydrogenase (HLADH) and photocatalytic, aerobic regeneration of NAD+. Green Chem., 2017, 19,376-379 DOI: 10.1039/C6GC02008A, Communication Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. M. Rauch, S. Schmidt, I. W. C. E. …

Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation

Fig. 3 Stereoselectivities of the new ApPDC-variants for the synthesis of (S)-PAC. The different variants were tested as wet cells, crude cell extracts, and purified enzymes. Reaction conditions: wet cells – 20 mM benzaldehyde; 200 mM pyruvate; 50 mM KPi-buffer (pH 6.5), 2.5 mM MgSO4; 0.1 mM ThDP; 20 °C; 800 rpm, 800 μL …

New Patent, (S)-pregabalin, WO 2017019791, Teva

Synthesis of (S)-pregabalin, Teva WO-2017019791 TEVA PHARMACEUTICALS INTERNATIONAL GMBH [CH/CH]; Schusselstrasse 12 8645 Jona (CH) (For All Designated States Except US). JANAGANI, Satyanarayana [US/US]; (US) (US only) Improved process for preparing (S)-pregabalin, useful for treating pain, seizures, convulsions and anxiety. Also claims novel intermediates of (S)-pregabalin and their preparation method. Pregabalin, a GABA alpha-2-delta subunit …

1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol)

1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol) Examples Example 1 – Preparation Of Compound 1 (4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-4-ol) 4-(3-(methylthio)phenyl)-1 – 4-(3-(methylsulfonyl)phenyl)- propylpiperidin-4-ol 1 -propylpiperidin-4-ol To a suspension of 4-hydroxy-4-(3-(methylthio)phenyl)-l-propylpiperidin-l-ium chloride (140g, 348mmol) in 710mL water were added 1.5g sodium tungstate dihydrate, and the mixture was heated to 45°C. 102mL of 33%H202 were added in 20min at 45-55°C. The suspension dissolved after 20mL …

Hoshinolactam, A new antitrypanosomal lactam

Tropical diseases caused by parasitic protozoa are a threat to human health, mainly in developing countries. Trypanosomiasis (Chagas disease and sleeping sickness) and leishmaniasis, inter alia, are classified as neglected tropical diseases, and over 400 million people are at risk of contracting these diseases. In addition, a parasite of the Trypanosoma genus, Trypanosoma brucei …

AMG-3969

AMG-3969 M.Wt: 522.46 Cas : 1361224-53-4 , MF: C21H20F6N4O3S WO 2012027261 PRODUCT PATENT Inventors Kate Ashton, Michael David Bartberger, Yunxin Bo, Marian C. Bryan, Michael Croghan, Christopher Harold Fotsch, Clarence Henderson Hale, Roxanne Kay Kunz, Longbin Liu, Nobuko Nishimura, Mark H. Norman, Lewis Dale Pennington, Steve Fong Poon, Markian Myroslaw Stec, Jean David Joseph St., Jr., Nuria …