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PF 06273340

PF-06273340 N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide CAS 1402438-74-7 Chemical Formula: C23H22ClN7O3 Molecular Weight: 479.925 Originator Pfizer ClassAnalgesics; Small molecules Mechanism of ActionUndefined mechanism 06 Oct 2014 Pfizer plans a phase I trial in Pain (In volunteers) in the Netherlands (NCT02260947) 07 Aug 2014 Discontinued – Phase-I for Pain (In volunteers) in Belgium (PO) 07 Aug 2014 Discontinued – Phase-I for Pain (In volunteers) …

BRD 2879

BRD2879 BRD-K56962879-001-01-5 CAS 1304750-47-7 Chemical Formula: C30H38FN3O5S Molecular Weight: 571.7084 3-cyclohexyl-1-(((4R,5R)-8-((3-fluorophenyl)ethynyl)-2-((S)-1-hydroxypropan-2-yl)-4-methyl-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b][1,4,5]oxathiazocin-5-yl)methyl)-1-methylurea 3-cyclohexyl-1-[[(4R,5R)-8-[2-(3-fluorophenyl)ethynyl]-2-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-5-yl]methyl]-1-methylurea BRD2879 is a potent and cell-active inhibitor of IDH1-R132H with a markedly different structure from previously reported probes with (IC50 = 50 nM for inhibiting IDH1-R132H enzyme). BRD2879 represents a new structural class of mutant IDH1 inhibitors that, with optimization, may prove useful …

PF 610355 Revisited

PF-610355 Molecular Formula C34H39N3O6S Average mass 617.755 Da PF 610655, PF-00610355; PF-610,355 2-[3-[2-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(methylsulfonylamino)phenyl]ethyl]amino]-2-methyl-propyl]phenyl]-N-[[3-(4-hydroxyphenyl)phenyl]methyl]ethanamide 862541-45-5 cas Originator Pfizer Class Antiasthmatics; Benzeneacetamides; Sulfonamides Mechanism of Action Beta 2 adrenergic receptor agonists Orphan Drug StatusNo On Fast trackNo Highest Development Phases Discontinued Asthma; Chronic obstructive pulmonary disease Most Recent Events 11 Aug 2011 Discontinued – Phase-I for Asthma in Belgium (Inhalation) 11 Aug 2011 Discontinued – Phase-II …

Solifenacin, солифенацин , سوليفيناسين , 索利那新 , コハク酸ソリフェナシン

SOLIFENACIN, YM-905 MF C23H26O2, a molecular weigt 362.4647 CAS 242478-37-1 солифенацин [Russian] سوليفيناسين [Arabic] 索利那新 [Chinese] 242478-37-1 (Solifenacin ) 242478-38-2 (Solifenacin Succinate) Solifenacin succinate, YM-67905 コハク酸ソリフェナシン Molecular Formula: C11H19NO7S Formula Weight: 480.56 CAS 242478-38-2 Usage Muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence. Usage sedative Usage Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class. (3R)-l-azabicyclo[2.2.2]oct-3-yl-(lS)-l-phenyl-3,4-dihydroisoquinoline-2-(lH)- carboxylate ((S)-phenyl-l?2,3,4-tetrahydroisoquinoline-2-carboxylic …

BMS-599793

BMS-599793 (DS003, BMS-599793) Cas 676489-50-2 Molecular Formula: C27H22N6O3 Molecular Weight: 478.512 g/mol 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxo-acetyl]-4-piperidylidene]-2-phenyl-acetonitrile; 2-[1-[2-(4-methoxy-7-pyrazin-2-yl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetyl]piperidin-4-ylidene]-2-phenylacetonitrile; Piperidine, 4-(cyanophenylmethylene)-1-[2-(4-methoxy-7-pyrazinyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-; US 20040063744 , US 20040186292, WO 2009114313 Inventors Andrew S. Thompson, Hua Cheng, Stanislaw Pikul Applicant International Partnership For Microbicides Stanislaw Pikul 2-(1-(2-(4-methoxy-7-(pyrazin-2-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanoyl)piperidin-4- ylidene)-2-phenylethanenitrile 1 (DS003, BMS-599793) is a small molecule entry inhibitor that interferes with HIV infection by binding to the gp120 protein.1 …

A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug

PAPER HETEROCYCLES An International Journal for Reviews and Communications in Heterocyclic Chemistry Web Edition ISSN: 1881-0942 Published online: 11th October, 2016 Paper | Regular issue | Prepress DOI: 10.3987/COM-16-13538 ■ A Concise and Highly Efficient Synthesis of Praziquantel as an Anthelmintic Drug Zhezhou Yang, Lin Zhang, Huirong Jiao, Rusheng Bao, Weiwei Xu, …

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

4-(6-chloro-1-oxo-3-thioxo-9,9a-dihydro-1H-imidazo[1,5-a]indol-2(3H)-yl)-2-(trifluoromethyl)-benzonitrile WILL BE UPDATED……… Prostate cancer, one of the most malignant tumors worldwide, is the second leading cause of cancer deaths among men in America . Although androgen deprivation therapy (ADT) has been proved to be effective initially, the tumor will eventually progress and develop into the lethal castration resistant prostate cancer (CRPC) . The …

BMS-741672

BMS-741672 N-((1R,2S,5R)-5-(Isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide BMS-741672 N-((lR,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6- (trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-l-yl)cyclohexyl)acetamide N-((1R,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide; C25 H33 F3 N6 O2, 506.56 Acetamide, N-[(1R,2S,5R)-5-[methyl(1-methylethyl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)-4-quinazolinyl]amino]-1-pyrrolidinyl]cyclohexyl]- CAS 1004757-96-3 PHASE 2, , Treatment of Type 2 Diabetes, Agents for Neuropathic Pain Chemokine CCR2 (MCP-1 Receptor) Antagonists Molecular Formula: C25H33F3N6O2 Molecular Weight: 506.574 g/mol Michael G. Yang, Robert J. Cherney Original Assignee Bristol-Myers Squibb Company Michael G. Yang, Robert J. Cherney, Martin G. …

Cetilistat, セチリスタット

Cetilistat, セチリスタット Molecular FormulaC25H39NO3 Average mass401.582 Da CAS 282526-98-1 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one 282526-98-1 [RN] 2-Hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one 2-hexadecyl-oxy-6-methyl-4H-3,1-benzoxazin-4-one 4H-3,1-Benzoxazin-4-one, 2-(hexadecyloxy)-6-methyl [282526-98-1] 2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one ATL-962; ATL962;ATL 962 Trade Name：Oblean® MOA：Pancreatic lipase inhibitor Indication：Obesity Status：Approved, 2013-09-20 JAPAN, Japan PMDA. Company：Norgine (Originator) , Takeda Cetilistat was approved by Pharmaceuticals Medical Devices Agency of Japan (PMDA) on September 20, 2013. It was developed by Norgine and Takeda, …

BMS-442608

BMS-442608 8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6R)- (6R)-6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione (R)-6-Hydroxybuspirone, UNII-93881477KV, CAS 477930-30-6, Molecular Formula, C21-H31-N5-O3, Molecular Weight, 401.5079 BMS-442608 is a 5-HT1A partial agonist. BMS-442608 is the R-enantiomer. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer. (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer. PAPER Enantioselective α-Hydroxylation of …