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BMS-852927

BMS-852927 CAS 256918-39-4 609.51 MW C29 H28 Cl2 F2 N2 O4 S MF 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol 1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-α,α-dimethyl- Treat metabolic syndrome Brett Busch, Ph.D. https://www.linkedin.com/in/brettbbusch Brett B. Busch, William C. Stevens, Jr., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu,Richard Martin, Raju Mohan Applicant Exelixis, Inc. Brett B. Busch, William C. Stevens, JR., Ellen K. Kick, Haiying Zhang, …

WAY-315193

7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one 7-f luoro-1 -[(1 S,2R)-1 -(3-fluorophenyl)-2-hydroxy-3- (methylamino)propyl]-3,3- dimethyl-1 ,3-dihydro-2H-indol-2-one hydrochloride WAY-315193 7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methyl amino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; Molecular Formula: C20H22F2N2O2 Molecular Weight: 360.397686 g/mol 7-Fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethylindolin-2-one Hydrochloride Callain Younghee Kim, Paige Erin Mahaney,Eugene John Trybulski, Puwen Zhang,Eugene Anthony Terefenko, Casey Cameron Mccomas, Michael Anthony Marella, Richard Dale Coghlan, Gavin David Heffernan,Stephen Todd Cohn, An Thien Vu, Joseph Peter Sabatucci, …

CB-618

CB-618, CB-238618 CAS 1463520-70-8 C8 H10 N4 O6 S, 290.25 Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester (25, 5R)-sulfuric acid mono-(2-[l,3,4]oxadiazol-2-yl-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl) ester SODIUM SALT sodium salt of (2S,5R)-sulfuric acid mono-(2-[1,3,4]oxadiazol-2-yl-7-oxo-1,6-diaza-bicyclo[3.2.1]oct-6-yl)ester CAS 1628207-16-8 C8 H10 N4 O6 S . Na Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1) PATENTS WO2013149121 US 20140275001 US 20150094472 WO 2016081452 Infection, multidrug resistant bacteria (MDR) in phase 1 …

Register Today for the ACS Symposium in India on Recent Advances in Drug Development, 11-12 November 2016 in Hyderabad, India

Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India Recent Advances in Drug Development Register Today for the ACS Symposium in India on Recent Advances in Drug Development To view this email as a web page, go here. Register now for the inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India. Be sure …

Ranitidine

Ranitidine Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production.[1] It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.[1] There is also tentative evidence of benefit for hives.[2] It can be taken by mouth, by injection into a muscle, or …

BMS 986001, Censavudine, Festinavir

BMS 986001 Censavudine, Festinavir Has anti-HIV activity. IN PHASE 2 CAS: 634907-30-5, UNII: 6IE83O6NGA, OBP 601, 4′-Ethynyl D4T, 4′-Ed4T, TDK-4-114 Molecular Formula, C12-H12-N2-O4, Molecular Weight, 248.2368 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine, 1-((2R,5R)-5-Ethynyl-5-(hydroxymethyl)-2H-furan-2-yl)-5-methyl-pyrimidine-2,4-dione, 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine INNOVATOR= YALE UNIVERSITY Festinavir is a nucleoside reverse transcriptase inhibitor (NRTI) which is being developed for the treatment of HIV infection. The drug has shown considerable efficacy in early development, and with perhaps …

BMS-986115

BMS-986115 CAS 1584647-27-7 (2R,3S)-N-((3S)-5-(3-Fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-lH-l,4-benzodiazepin- 3-yl)-2, -bis(3,3,3-trifluoropropyl)succinamide MW: 574.4945, C26-H25-F7-N4-O3, UNII: LSK1L593UU 10-Nitrooleate, CTK3B7458, CTK3C3167, 9-Octadecenoic acid, 10-nitro-, 875685-46-4, AG-L-63109, 9-Octadecenoic acid, 10-nitro-, (9E)-, 88127-53-1 FOR advanced solid tumors Originator Bristol-Myers Squibb Class Antineoplastics Mechanism of Action Amyloid precursor protein secretase inhibitors; Notch signalling pathway inhibitors Phase I Solid tumours Most Recent Events 30 Aug 2016Bristol-Myers Squibb terminates a phase I trial …

BMS 906024

BMS 906024 cas 1401066-79-2 MF C26H26F6N4O3 MW 556.500 (2R,3S)-N-[(3S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)succinamide Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2R,3S)- (2R,35)-N-((35)-l-Methyl-2-oxo-5-phenyl-2,3-dihydro-lH-l,4-benzodiazepin-3-yl)-3- (2,2,2-trifluoroethyl)-2-(3,3,3-trifluoropropyl)succinamide Claude Quesnelle, Soong-Hoon Kim, Francis Lee, Ashvinikumar Gavai Applicant Bristol-Myers Squibb Company Ashvinikumar Gavai Claude Quesnelle Senior Research Investigator/Chemist at Bristol-Myers Squibb RICHARD LEE BMS-906024 is a novel, potent Notch receptor inhibitor . Cancers have a tendency to relapse or to become …

MCC 950

MCC 950 256373-96-3 (sodium salt); 210826-40-7 (free form). MCC950; CP-456773; CAS 210826-40-7; DSSTox_CID_27301; DSSTox_RID_82252; DSSTox_GSID_47301; CP-456,773; CRID3 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea C20H24N2O5S Molecular Weight: 404.47996 g/mol CP-456773, also known as MCC950 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase …

BMT-145027

BMT-145027 CAS ? C23H14ClF3N4 Exact Mass: 438.0859 3-(4-chloro-3-(trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 3-(4-chloro-3- (trifluoromethyl)phenyl)-4-cyclopropyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 1H NMR (600 MHz, DMSO-d6) δ = 14.46 (br. s., 1H), 8.24 (s, 1H), 8.14 (d, J=8.1 Hz, 1H), 7.88 (d, J=8.3 Hz, 1H), 7.84 (dd, J=6.1, 2.7 Hz, 2H), 7.61 – 7.55 (m, 3H), 2.50 – 2.45 (m, 1H), 0.74 – 0.68 (m, 2H), …