It’s only fair to share… Tegileridine WeightAverage: 434.624Monoisotopic: 434.293328472 Chemical FormulaC28H38N2O2 (1S,4S)-4-ethoxy-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]-1,2,3,4-tetrahydronaphthalen-1-amine Tegileridine fumarate CAS#2245827-85-2 (fumarate) Chemical Formula: C32H42N2O6 Exact Mass: 550.3000 Molecular Weight: 550.70 CHINA 2025, APPROVALS 2025, AISUTE, Jiangsu Hengrui Tegileridine is under investigation in clinical trial NCT06458400 (To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain). Tegileridine is a drug …
Category «Uncategorized»
Velagliflozin
It’s only fair to share… Velagliflozin 2-[(4-cyclopropylphenyl)methyl]-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzonitrile Velagliflozin L-proline H2O Velagliflozin, sold under the brand name Senvelgo, is an antidiabetic medication used for the treatment of cats.[2][4][5] Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor.[6] It is taken by mouth.[2] Velagliflozin is the active ingredient of the first oral liquid medication approved by the Food and Drug Administration for the treatment of …
Cetagliptin
It’s only fair to share… Cetagliptin CAS No. FREE FORM : 2243737-33-7 C18H18F6N4O, 420.4 g/mol [ Cetagliptin Phosphate 2243737-33-7 ] 분자량 MW 518.35 화학식 MF C18H21F6N4O5P (3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one (3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one CHINA 2024, APPROVALS 2024, CGeneTec, DIABETES, RegisteredType 2 diabetes mellitus CHINA 2024 Cetagliptin (CGT-8012) is an orally bioavailable, dipeptidyl peptidase 4 enzyme (DPP-4) inhibitor (‘gliptin’) class drug. It was …
Cofrogliptin
It’s only fair to share… Cofrogliptin HSK 7653 (2R,3S,5R,6S)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-6-(trifluoromethyl)oxan-3-amine APPROVALS 2024, CHINA 2024, Haisco Pharmaceutical Group Co, Beichangping, DIABETES Cofrogliptin (developmental name HSK7653) is a long-acting DPP4 inhibitor dosed once every two weeks.[1][2][3][4] Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 …
Janagliflozin
It’s only fair to share… Janagliflozin WeightAverage: 460.95Monoisotopic: 460.1652664 Chemical FormulaC25H29ClO6 China 2024, approvals 2024, Jilin Huisheng Biopharmaceutical Co, sihuan, SGLT2 inhibitors, Huiyoujing Janagliflozin is an SGLT2 inhibitor developed by Sihuan Pharmaceutical.[1][2][3][4][5][6] It is approved in China for the treatment of type 2 diabetes.[7] PAPER https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1751524 (71) (a) Wu, F. US9315438B2, 2016. (b) Wu, F. EP2891654A1, 2014. Initially, the two advanced …
Zorifertinib
It’s only fair to share… Zorifertinib AZD 3759 CAS 1626387-80-1, 67SX9H68W2 WeightAverage: 459.91Monoisotopic: 459.1473455 Chemical FormulaC22H23ClFN5O3 [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate China 2024, APPROVALS 2024, Alpha Biopharma, ASTRA ZENECA, Zorifer, Zorifertinib (AZD3759) is a drug for the treatment of cancer.[1] In China, it was approved in 2024 for locally advanced or metastatic non-small-cell lung cancer (NSCLC) that has epidermal growth factor receptor exon 19 …
Garsorasib
It’s only fair to share… Garsorasib Chemical Formula: C32H32F2N8O2 Exact Mass: 598.2616 Molecular Weight: 598.66 D 1553, Chia Tai Tianqing, CHINA 2024, APPROVALS 2024, Anfangning, Garsorasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, garsorasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. …
Fulzerasib
It’s only fair to share… Fulzerasib GFH925 CAS No. : 2641747-54-6 Molecular Weight 617.07 Formula C32H30ClFN6O4 (7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-9-methyl-12-(4-methyl-2-propan-2-ylpyridin-3-yl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione (7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-9-methyl-12-(4-methyl-2-propan-2-ylpyridin-3-yl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione CHINA 2024, APPROVALS 2024, Innovent Biologics, DUPERT Fulzerasib (Dupert®; Innovent Biologics/GenFleet Therapeutics) is an orally active small molecule inhibitor of the KRAS G12C mutant protein being developed for the treatment of solid tumors harboring the KRAS G12C oncogenic …
Golidocitinib
It’s only fair to share… Golidocitinib CAS 2091134-68-6 WeightAverage: 489.584Monoisotopic: 489.260071274 Chemical FormulaC25H31N9O2 (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide Approvals 2024, china 2024, DZD 4205, DIZAL, Gao Ruizhe, Golidocitinib is a pharmaceutical drug for the treatment of cancer. In June 2024, it was given conditional approval in China for the treatment of relapsed or refractory peripheral T-cell lymphoma.[1] Golidocitinib is classified as …
Oritinib
It’s only fair to share… Oritinib CHINA 2024, Nanjing Sanhome Pharmaceutical. N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide Oritinib is an investigational new drug currently under investigation for its potential use in cancer treatment.[1][2] As a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, oritinib targets specific enzymes involved in the signaling pathways that regulate cell division and survival, which are often dysregulated in cancer cells.[1] Oritinib (SH-1028), …