It’s only fair to share… BMS-986142 (2S,5R,3S)-6-fluoro-5-(3-(8-fluoro-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-methylphenyl)-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-l-methyl-2,4-dioxo-l,2-dihydroquinazolin-3(4H)-yl)-2- methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-lH-carbazole-8- carboxamide Molecular Formula, C32-H30-F2-N4-O4, Molecular Weight, 572.609, RN: 1643368-58-4 UNII: PJX9GH268R Originator Bristol-Myers Squibb Class Anti-inflammatories; Antirheumatics; Small molecules Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors Phase II Rheumatoid arthritis; Sjogren’s syndrome 24 Jun 2018 Biomarkers information updated 07 Jun 2018 Bristol-Myers Squibb completes a phase II trial in Rheumatoid arthritis (Treatment-experienced) in Argentina, Austria, Belgium, …
Category «Uncategorized»
Icosapent ethyl, イコサペント酸エチル
It’s only fair to share… Icosapent ethyl 330.5042 , C22H34O2 cas 86227-47-6 / 73310-10-8 ethyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate Ethyl eicosapentaenoic acid イコサペント酸エチル (5Z,8Z,11Z,14Z,17Z)-Eicosapetaenoic acid ethyl ester (all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)- [ACD/Index Name] 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (all-Z)- 6GC8A4PAYH 86227-47-6 [RN] all-cis-5,8,11,14,17-Eicosapentaenoic Acid Ethyl Ester Timnodonic acid ethyl ester Vascepa 5,8,11,14,17-Eicosapentaenoic acid, ethyl ester, (all-Z)- (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl …
Revefenacin, ревефенацин , ريفيفيناسين , 瑞维那新 ,
It’s only fair to share… Revefenacin; 864750-70-9; TD-4208; UNII-G2AE2VE07O; G2AE2VE07O; TD-4208; GSK-1160724; 160724; GSK 1160724; TD-4028; YUPELRI Molecular Formula: C35H43N5O4 Molecular Weight: 597.76 g/mol [1-[2-[[4-[(4-carbamoylpiperidin-1-yl)methyl]benzoyl]-methylamino]ethyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate TD-4208 UNII:G2AE2VE07O ревефенацин [Russian] [INN] ريفيفيناسين [Arabic] [INN] 瑞维那新 [Chinese] [INN] Revefenacin is under investigation for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Originator Theravance Developer Theravance Biopharma Class Antiasthmatics; Biphenyl compounds; Carbamates; Piperidines Mechanism of Action Muscarinic receptor …
Sarecycline , サレサイクリン
It’s only fair to share… Sarecycline サレサイクリン MW 487.5024, MF C24H29N3O8 FREE FORM Paratek INNOVATOR FDA 2018/10/1 APPROVED SEYSARA, ALMIRALL, for the oral treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-7-{[methoxy(methyl)amino]methyl}-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide 1035654-66-0 [RN] FREE FORM 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-, (4S,4aS,5aR,12aS)- 94O110CX2E 9743 P005672, P 005672 CAS 1035979-44-2 HCl Molecular …
AKN 028
It’s only fair to share… AKN-028 CAS 1175017-90-9 Chemical Formula: C17H14N6 Molecular Weight: 302.33 N-3-(1H-indol-5-yl)-5-pyridin-4-yl-pyrazine-2,3-diamine N2-(1H-indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine Originator Swedish Orphan Biovitrum Developer Akinion Pharmaceuticals Class Antineoplastics; Small molecules Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Proto oncogene protein c-kit inhibitors Phase I/II Acute myeloid leukaemia 01 Mar 2016 Akinion Pharmaceuticals terminates phase I/II trial in Acute myeloid leukaemia in Czech Republic, …
Technetium (99mTc) tetrofosmin, テトロホスミンテクネチウム (99mTc)
It’s only fair to share… Technetium (99mTc) tetrofosmin, 99mTc-Tetrofosmin テトロホスミンテクネチウム (99mTc) Formula C36H80O10P4Tc Molar mass 895.813 g/mol CAS Number 127455-27-0 127502-06-1 (tetrofosmin) UNII42FOP1YX93 2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane;technetium-98;dihydrate Technetium Tc 99m tetrofosmin; Technetium Tc-99m tetrofosmin; TECHNETIUM TC-99M TETROFOSMIN KIT; Tc-99m tetrofosmin; Technetium-99 tetrofosmin; Technetium (99mTc) tetrofosmin Title: Tetrofosmin CAS Registry Number: 127502-06-1 CAS Name: 6,9-Bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane Additional Names: ethylenebis[bis(2-ethoxyethyl)phosphine] Manufacturers’ Codes: P53 Molecular Formula: C18H40O4P2 Molecular …
Tasimelteon, タシメルテオン
It’s only fair to share… Tasimelteon N-([(1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl]methyl)propanamide, 609799-22-6 [RN] 8985 Hetlioz [Trade name] N-{[(1R,2R)-2-(2,3-Dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide [ACD/IUPAC Name] Propanamide, N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]- [ACD/Index Name] SHS4PU80D9 609799-22-6 cas, BMS-214778; VEC-162, ATC:N05CH03 Use:Treatment of sleep disorder; Melatonin receptor agonist (1R,2R)-N-[2-(2,3-dihydrobenzofuran-4-yl)cyclopropylmethyl]propanamide Formula:C15H19NO2, MW:245.3 g/mol Hetlioz Vanda Pharmaceuticals, 2014 Approved fda 2014 EMA Tasimelteon is a white to off-white crystalline powder, it is non hygroscopic, soluble in water across relevant …
Glycopyrrolate Tosylate
It’s only fair to share… Glycopyrrolate Tosylate Molecular Formula: C26H35NO6S Molecular Weight: 489.627 g/mol (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate;4-methylbenzenesulfonate CAS 873295-46-6 , C19 H28 N O3 . C7 H7 O3 S, Pyrrolidinium, 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-, 4-methylbenzenesulfonate (1:1) Glycopyrronium tosylate monohydrate Molecular Formula, C19-H28-N-O3.C7-H8-O3-S.H2-O, Molecular Weight, 508.6522 https://chem.nlm.nih.gov/chemidplus/structure/1624259-25-1?maxscale=30&width=300&height=300 CAS 1624259-25-1, C19 H28 N O3 . C7 H7 O3 S . H2 O, Pyrrolidinium, 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-, 4-methylbenzenesulfonate, hydrate (1:1:1) Dermira (Originator) DRM-04 DRM-04B DRM-04 tosylate monohydrate DRM04 DRM04 …
Diazoxide choline
It’s only fair to share… Diazoxide choline, RN: 1098065-76-9 UNII: 2U8NRZ7P8L Diazoxide choline; UNII-2U8NRZ7P8L; 2U8NRZ7P8L; YLLWQNAEYILHLV-UHFFFAOYSA-N Molecular Formula: C13H20ClN3O3S Molecular Weight: 333.831 g/mol Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, compd. with 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine dioxide (1:1) 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine dioxide compd. with 2-hydroxy-N,N,N-trimethylethanaminium (1:1) 7-chloro-3-methyl-1$l^{6},2,4-benzothiadiazin-2-ide 1,1-dioxide;2-hydroxyethyl(trimethyl)azanium Diazoxide CAS: 364-98-7 FREE FORM 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide 4H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide (7CI) 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Diazoxide Dizoxide Eudemine …
Zoledronic acid
It’s only fair to share… Zoledronic acid CGP-42446, ZOL-446 ATC:M05BA08 Use:antineoplastic, bone resorption inhibitor, biphosphonate Chemical name:[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis[phosphonic acid] Formula:C5H10N2O7P2 MW:272.09 g/mol CAS-RN:118072-93-8 Derivatives Disodium salt tetrahydrate Formula:C5H8N2Na2O7P2 • 4H2O MW:388.11 g/mol CAS-RN:165800-07-7 Trisodium salt hydrate Formula:C5H7N2Na3O7P2 • 2/5H2O MW:1726.21 g/mol CAS-RN:165800-08-8 Zoledronic Acid CAS Registry Number: 118072-93-8; 165800-06-6 (monohydrate) CAS Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid Additional Names: 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid Manufacturers’ Codes: CGP-42446 Trademarks: Zometa …