It’s only fair to share… Selexipag Molecular FormulaC26H32N4O4S Average mass496.622 Da Selexipag, Uptravi 475086-01-2 CAS (C26H32N4O4S, Mr = 496.6 g/mol) A prostacyclin receptor (PGI2) agonist used to treat pulmonary arterial hypertension (PAH). NIPPON SHINYAKU….INNOVATOR セレキシパグ UNII-5EXC0E384L селексипаг [Russian] [INN] سيليكسيباق [Amharic] [INN] 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}-N-(methylsulfonyl)acetamide 475086-01-2 [RN] 5EXC0E384L 9231 Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)- Selexipag (brand name Uptravi) is a drug developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). …
Category «Uncategorized»
VIXOTRIGINE, раксатригин , راكساتريجين , 维索曲静 ,
It’s only fair to share… VIXOTRIGINE Molecular FormulaC18H19FN2O2 Average mass314.354 Da раксатригин , راكساتريجين , 维索曲静 , (5R)-5-{4-[(2-Fluorobenzyl)oxy]phényl}-L-prolinamide 10287 2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, (2S,5R)- 934240-30-9 [RN] QQS4J85K6Y Raxatrigine UNII:QQS4J85K6Y Vixotrigine (INN, USAN), formerly known as raxatrigine (INN, USAN), is an analgesic which is under development by Convergence Pharmaceuticals for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia (TGN).[1][2][3] Vixotrigine was originally claimed to be a selective central Nav1.3 blocker, but was subsequently redefined as a selective peripheral Nav1.7 blocker.[4]Following this, vixotrigine …
Lumateperone
It’s only fair to share… Lumateperone Molecular FormulaC24H28FN3O Average mass393.497 Da 4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one 1-Butanone, 1-(4-fluorophenyl)-4-(2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)- 1-(4-fluorophenyl)-4-{4-methyl-1,4,12-triazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-5,7,9(16)-trien-12-yl}butan-1-one 313368-91-1 [RN] 70BSQ12069, Lumateperone, PHASE 3, ITI-007 4- methylbenzenesulfonate. SALT Molecular Formula: C31H36FN3O4S Molecular Weight: 565.704 g/mol (6bR,10aS)-8-[4-(4-Fluorophenyl)-4-oxobutyl]-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3‘,4’:4,5]pyrrolo[1,2,3-de]quinoxalin-8-ium 4-methylbenzenesulfonate 1187020-80-9 [RN] 1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-, 4-methylbenzenesulfonate (1:1) ITI-007 tosylate JIE88N006O Lumateperone tosylate [USAN] UNII:JIE88N006O ITI 007 Originator Bristol-Myers Squibb Develope rIntra-Cellular Therapies Class Antidepressants; Antipsychotics; Pyrroles; Quinoxalines; Sleep disorder …
Nemorexant
It’s only fair to share… Nemorexant ACT-541468, UNII LMQ24G57E9 [(2S)-2-(5-Chloro-4-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone 1505484-82-1 [RN] LMQ24G57E9 Methanone, [(2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl][5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]- Originator Actelion Pharmaceuticals Developer Idorsia Pharmaceuticals Class Sleep disorder therapies Mechanism of Action Orexin receptor type 1 antagonists; Orexin receptor type 2 antagonists Phase III Insomnia 19 Oct 2018 Idorsia Pharmaceuticals plans a phase I trial for Liver disorders (Hepatic impairment) in November 2018 (PO) (NCT03713242) 09 Oct …
Eflornithine, эфлорнитин , إيفلورنيثين , 依氟鸟氨酸 , エフロルニチン
It’s only fair to share… Eflornithine DFMO, RMI-71782ATC:P01CX03, BRN 2250529 / HSDB 7923 / MDL 71782 / RFI 7178 / RMI 71782 Ornithine, 2-(difluoromethyl)- UNII:ZQN1G5V6SR ZQN1G5V6SR эфлорнитин [Russian] [INN] إيفلورنيثين [Arabic] [INN] 依氟鸟氨酸 [Chinese] [INN] エフロルニチン 5551 67037-37-0 [RN] 70052-12-9 CAS a-Difluoromethylornithine (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid Use:hirsutism treatment inhibitor of ornithine decarboxylase Chemical name:2-(difluoromethyl)-dl-ornithine Formula:C6H12F2N2O2, MW:182.17 g/mol CAS-RN:67037-37-0 LD50:>3000 mg/kg (M, i.p.); >5000 mg/kg (M, p.o.); 1364 μg/kg (R, intracerebral) Eflornithine, also known as …
Pirlindole
It’s only fair to share… Pirlindole Molecular FormulaC15H18N2 Average mass226.317 Da 1H-Pyrazino[3,2,1-jk]carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl- 2,3,3a,4,5,6-hexahydro-8-methyl-1h-pyrazino[3,2,1-jk]carbazole 4615 60762-57-4 [RN] FREE FORM, 16154-78-2 (hydrochloride) 12-methyl-1,4-diazatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁵]hexadeca-9(16),10,12,14-tetraene 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole UNII:V39YPH45FZ V39YPH45FZ INNOVATOR Russian Academy of Medical Sciences For the treatment of major depression. Pirlindole is a reversible inhibitor of monoamine oxidase A (RIMA) which was developed and is currently used in Russia as an antidepressant. It …
Isosorbide-2-acetate
It’s only fair to share… Spectral Data for 1 MS (ESI): calcd for [M + Na]+, 211.11; found, 211.11. IR (KBr) cm–1: 1732.08 (C═O), 3398.57 (−OH). 1H NMR (400 MHz, CD3OD): δ 5.11 (d, J = 3.6 Hz, 1H), 4.76 (s, 1H), 4.54 (t, J = 4.6 Hz, 1H), 4.49 (d, J = 4.4 Hz, 1H), 4.27 (td, J = 6.7, 5.1 Hz, 1H), …
CIFORADENANT
It’s only fair to share… CIFORADENANT 1202402-40-1 Chemical Formula: C20H21N7O3 Molecular Weight: 407.434 CPI-444, CPI 444, CPI444, V81444, V-81444, V 81444, UNII 8KFO2187CP Corvus Pharmaceuticals, Inc. PHASE 1 (S)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine 3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-5-AMINE, 7-(5-METHYL-2-FURANYL)-3-((6-((((3S)-TETRAHYDRO-3-FURANYL)OXY)METHYL)-2-PYRIDINYL)METHYL)- (73 S)-15 -methyl-6-oxa-2(7,3)-[1,2,3]triazolo[4,5- d]pyrimidina-4(2,6)-pyridina-1(2)-furana-7(3)- oxolanaheptaphan-25 -amine adenosine receptor antagonist Ciforadenant, also known as CPI-444 and V81444, is an orally administered antagonist of the adenosine A2A receptor. …
Netarsudil, Нетарсудил , نيتارسوديل , 奈舒地尔 , ネタルスジル ,
It’s only fair to share… Netarsudil Molecular Formula: C28H27N3O3 Molecular Weight: 453.542 g/mol Netarsudil; UNII-W6I5QDT7QI; W6I5QDT7QI; 1254032-66-0; Netarsudil [USAN]; AR-11324 free base 1422144-42-0 (mesylate) 1254032-66-0 (free base) 1253952-02-1 (HCl) [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate 4-[(2S)-3-Amino-1-(6-isoquinolinylamino)-1-oxo-2-propanyl]benzyl 2,4-dimethylbenzoate [ACD/IUPAC Name] Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester W6I5QDT7QI Нетарсудил [Russian] [INN] نيتارسوديل [Arabic] [INN] 奈舒地尔 [Chinese] [INN] ネタルスジル; Inventor – Aerie Pharmaceuticals, Inc. Approved by US-FDA in December-2017 for dimesylate salt AR …
Molidustat
It’s only fair to share… Molidustat UNII-9JH486CZ13, cas no 1154028-82-6, MW: 314.3076 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Originator Bayer Schering Pharma Developer Bayer HealthCare Pharmaceuticals Class Antianaemics; Morpholines; Pyrazoles; Pyrazolones; Pyrimidines; Small molecules; Triazoles Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors Phase III Anaemia 24 Jun 2018 Biomarkers information updated 23 Jun 2018 Bayer initiates enrolment in the MIYABI HD-M phase III …