It’s only fair to share… STAUROSPORINE (+)-Staurosporine Molecular FormulaC28H26N4O3 Average mass466.531 Da (2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one 6,10-Epoxy-6H,16H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-16-one, 7,8,9,10,17,18-hexahydro-7-methoxy-6-methyl-8-(methylamino)-, (6S,7R,8R,10R)- 62996-74-1 [RN] AM-2282 Antibiotic 230 antibiotic am 2282 Staurosporine CAS Registry Number: 62996-74-1 CAS Name: (9S,10R,11R,13R)- 2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3¢,2¢,1¢-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Manufacturers’ Codes: AM-2282; CGP-39360 Molecular Formula: C28H26N4O3, Molecular Weight: 466.53 Percent Composition: C 72.09%, H 5.62%, N 12.01%, O 10.29% Literature References: Protein kinase C inhibitor; alkaloid isolated from Streptomyces staurosporeus. Isoln: …
Category «Uncategorized»
Alpha lipoic acid
It’s only fair to share… Alpha lipoic acid (+)-Thioctic acid Molecular FormulaC8H14O2S2 Average mass206.326 Da 5-[3-(1,2-Dithiolanyl)]pentanoic Acid 5-19-07-00237 [Beilstein] 62-46-4 [RN] (+)-Thioctic acid, (+)-α-Lipoic acid, (3R)-1,2-Dithiolane-3-pentanoic acid (R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-(+)-lipoic acid, (R)-(+)-α-Lipoic acid (R)-6,8-Dithiooctanoic acid, (R)-6,8-thioctic acid, (R)-α-Lipoic Acid, (R)-α-Lipoic Acid 1,2-Dithiolane-3-pentanoic acid, (3R)- 5-[(3R)-1,2-Dithiolan-3-yl]pentanoic acid d-Thioctic acid, (R)-(+)-alpha-Lipoic acid, (R)-(+)-Thioctic acid, Dexlipotam Thioctic Acid CAS Registry Number: 62-46-4 CAS Name: 1,2-Dithiolane-3-pentanoic acid Additional Names: 1,2-dithiolane-3-valeric acid; …
Maribavir
It’s only fair to share… Maribavir Molecular FormulaC15H19Cl2N3O4 Average mass376.235 Da FDA APROVED 11/23/2021, Livtencity 1263 W94, 1263W94 176161-24-3 [RN] 1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl- UNII-PTB4X93HE1, марибавир , ماريبافير ,马立巴韦 , BW-1263W94 Camvia, D04859, G1263, GW257406X 1263W94; BW-1263W94; GW-1263; GW-257406X; SHP-620; VP-41263 Company：GlaxoSmithKline (Originator) , Shire MOA：UL97 kinase inhibitor Indication：CMV prophylaxis To treat post-transplant cytomegalovirus (CMV) infection/disease that does not respond (with or without genetic mutations that cause resistance) to available antiviral …
AMOROLFINE
It’s only fair to share… AMOROLFINE (2R,6S)-2,6-Dimethyl-4-{2-methyl-3-[4-(2-methyl-2-butanyl)phenyl]propyl}morpholine (2R,6S)-2,6-Dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine 78613-35-1 [RN] (±)-cis-2,6-Dimethyl-4-(2-methyl-3-(p-tert-pentylphenyl)propyl)morpholine Ro 14-4767-002 аморолфин , أمورولفين ,阿莫罗芬 , Title: Amorolfine CAS Registry Number: 78613-35-1 CAS Name:cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine Additional Names:cis-4-[3-(4-tert-amylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine; (±)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine Manufacturers’ Codes: Ro-14-4767/000 Molecular Formula: C21H35NO Molecular Weight: 317.51 Percent Composition: C 79.44%, H 11.11%, N 4.41%, O 5.04% Literature References: Antimycotic morpholine derivative; inhibits fungal ergosterol biosynthesis. Prepn (unspec stereochem): A. Pfiffner, K. …
Acetaminosalol
It’s only fair to share… Acetaminosalol Molecular FormulaC15H13NO4 Average mass271.268 Da ацетаминосалол [Russian] [INN], أسيتامينوسالول [Arabic] [INN], 醋氨沙洛 [Chinese] [INN] (1E)-N-{4-[(2-Hydroxybenzoyl)oxy]phenyl}ethanimidic acid 118-57-0 [RN] 204-261-3 [EINECS] CAS Registry Number: 118-57-0 CAS Name: 2-Hydroxybenzoic acid 4-(acetylamino)phenyl ester Additional Names: p-acetamidophenyl salicylate; acetylaminophenyl salicylate; acetyl-p-aminosalol; p-acetylaminophenol salicylic acid ester; phenetsal Trademarks: Salophen (Bayer); Phenosal Molecular Formula: C15H13NO4 Molecular Weight: 271.27 Percent Composition: C 66.41%, H 4.83%, N 5.16%, O 23.59% Literature References: Prepn: Brewster, J. Am. …
LINZAGOLIX
It’s only fair to share… LINZAGOLIX CAS 935283-04-8 C22H15F3N2O7S Hormone Antagonists 3-[5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl]-2,4-dioxo-1H-thieno[3,4-d]pyrimidine-5-carboxylic acid WHO 10711 Treatment of Endometriosis Pain and Uterine Myoma-Associated Heavy Menstrual Bleeding OriginatorKissei Pharmaceutical DeveloperKissei Pharmaceutical; ObsEva Class2 ring heterocyclic compounds; Antihormones; Antineoplastics; Carboxylic acids; Fluorinated hydrocarbons; Ketones; Pyrimidines; Small molecules; Thiophenes Mechanism of ActionLHRH receptor antagonists PreregistrationUterine leiomyoma Phase IIIEndometriosis Phase IIAdenomyosis …
Ropeginterferon alfa-2b
It’s only fair to share… PCDLPQTHSL GSRRTLMLLA QMRRISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE (Disulfide bridge: 2-99, 30-139) Ropeginterferon alfa-2b AOP2014 CAS 1335098-50-4 UNII981TME683S FDA APPROVED, 2021/11/12, BESREMI PEPTIDE, Antineoplastic, Antiviral Polycythemia vera (PV) is the most common Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), characterized by increased hematocrit and platelet/leukocyte counts, …
SULCONAZOLE
It’s only fair to share… SULCONAZOLE сульконазол , سولكونازول , 硫康唑 Molecular FormulaC18H15Cl3N2S Average mass397.749 Da 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]- [ACD/Index Name] 4332 5D9HAA5Q5S 61318-90-9 [RN] (±)-1-[2,4-Dichloro-b-[(p-chlorobenzyl)thio]phenethyl]imidazole 1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole : Sulconazole CAS Registry Number: 61318-90-9 CAS Name: 1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Additional Names: (±)-1-[2,4-dichloro-b-[(p-chlorobenzyl)thio]phenethyl]imidazole Molecular Formula: C18H15Cl3N2S Molecular Weight: 397.75 Percent Composition: C 54.35%, H 3.80%, Cl 26.74%, N 7.04%, S 8.06% Literature References: Prepn: K. A. M. Walker, DE2541833; idem,US4055652 (1976, 1977 both to …
TNO 155
It’s only fair to share… TNO 155 2-Oxa-8-azaspiro[4.5]decan-4-amine, 8-[6-amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-, (3S,4S)- (3S,4S)-8-[6-Amino-5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine (3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine Molecular Weight 421.95 Formula C₁₈H₂₄ClN₇OS CAS No. 1801765-04-7 PTPN11 inhibitor TNO155 SHP2 inhibitor TNO155 TNO-155 TNO155 UNII-FPJWORQEGI TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially …
CILENGITIDE
It’s only fair to share… IUPAC Condensed cyclo[Arg-Gly-Asp-D-Phe-N(Me)Val] HELM PEPTIDE1{R.G.D.[dF].[meV]}$PEPTIDE1,PEPTIDE1,5:R2-1:R1$$$ IUPAC cyclo[L-arginyl-glycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl] CILENGITIDE Molecular FormulaC27H40N8O7 Average mass588.656 Da 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid 188968-51-6 [RN] 4EDF46E4GI 7823 циленгитид سيلانجيتيد 西仑吉肽 EMD 121974, EMD-121974, UNII-4EDF46E4GI 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid Cilengitide has been in phase III clinical trials by Merck Serono and NCI for the treatment of glioblastoma multiforme. However, this research has been …