It’s only fair to share… Cevimeline セビメリン Molecular FormulaC10H17NOS Average mass199.313 Da cis-2′-Methylspiro[4-azabicyclo[2.2.2]octane-2,5′-[1,3]oxathiolane] Evoxac [Trade name] Spiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane], 2‘-methyl-, (2’R,3R)- Cevimeline CAS Registry Number: 107233-08-9 CAS Name: (2¢R,3R)-rel-2¢-Methylspiro[1-azabicyclo[2.2.2]octane-3,5¢-[1,3]oxathiolane] Additional Names: (±)-cis-2-methylspiro[1,3-oxathiolane-5,3¢-quinuclidine] Molecular Formula: C10H17NOS Molecular Weight: 199.31 Percent Composition: C 60.26%, H 8.60%, N 7.03%, O 8.03%, S 16.09% Literature References: Muscarinic M1 and M3 receptor agonist. Prepn: A. Fisher et al., JP Kokai 61 280497; eidem, US 4855290; (1986, 1989 …
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FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism
It’s only fair to share… FDA approves new oral testosterone capsule (testosterone undecanoate) for treatment of men with certain forms of hypogonadism March 27, 2019 Release The U.S. Food and Drug Administration today approved Jatenzo (testosterone undecanoate), an oral testosterone capsule to treat men with certain forms of hypogonadism. These men have low testosterone …
Batimastat, バチマスタット
It’s only fair to share… Batimastat バチマスタット Formula C23H31N3O4S2 cas 130370-60-4 Mol weight 477.6399 Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))- DESCARBOXY-NOR-N(ω)-HYDROXY-L-ARGININE DSX EJ6675000 UNII:BK349F52C9 (2R,3S)-N4-Hydroxy-2-isobutyl-N1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-3-[(2-thienylsulfanyl)methyl]succinamide (2R,3S)-N4-hydroxy-N1-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-2-(2-methylpropyl)-3-[(thiophen-2-ylsulfanyl)methyl]butanediamide (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide (2S,3R)-5-Methyl-3-(((aS)-a-(methylcarbamoyl)phenethyl)carbamoyl)-2-((2-thienylthio)methyl)hexanohydroxamic Acid [2R-[1(S*),2R*,3S*]]-N4-Hydroxy-N1-[2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butane Diamide 130370-60-4 [RN] 7154 Batimastat [BAN] [INN] [USAN] [Wiki] BK349F52C9 CAS Registry Number: 130370-60-4 CAS Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide Additional Names: (2S,3R)-5-methyl-3-[[(aS)-a-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(2-thienylthio)methyl]hexanohydroxamic acid; [4-(N-hydroxyamino)-2R-isobutyl-3S-(2-thienylthiomethyl)succinyl]-L-phenylalanine-N-methylamide Manufacturers’ Codes: BB-94 Molecular Formula: C23H31N3O4S2 Molecular Weight: 477.64 Percent Composition: C 57.84%, H 6.54%, N 8.80%, O …
TASELISIB
It’s only fair to share… Molecular FormulaC24H28N8O2 Average mass460.531 Da RG7604,Taselisib GDC-0032, GDC0032;GDC 0032, RO5537381 1282512-48-4 [RN] 1H-Pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl- UNII:L08J2O299M 10.1021/jm4003632 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide NMR http://file.selleckchem.com/downloads/nmr/s710301-gdc-0032-hnmr-selleck.pdf POLYMORPHS almost A to Z, US9266903 Taselisib (GDC-0032) is an experimental cancer drug in development by Roche. Molecule is a complex heterocycle with no chiral centres, hazardous materials are used in synthesis, preparation …
Abikoviromycin
It’s only fair to share… Abikoviromycin Molecular FormulaC10H11NO Average mass161.200 Da CAS Registry Number: 31774-33-1 CAS Name: 7-Ethylidene-1a,2,3,7-tetrahydrocyclopent[b]oxireno[c]pyridine (1aR,7E,7aS)-7-Ethylidene-1a,2,3,7-tetrahydrocyclopenta[b]oxireno[c]pyridine [ACD/IUPAC Name] abikoviromycin Cyclopent(b)oxireno(c)pyridine, 7-ethylidene-1a,2,3,7-tetrahydro-, (1aR,7E,7aS)- Cyclopent[b]oxireno[c]pyridine, 7-ethylidene-1a,2,3,7-tetrahydro-, (1aR,7E,7aS)- Additional Names: 4,4a-epoxy-5-ethylidene-2,3,4,4a-tetrahydro-5H-1-pyridine; abicoviromycin; latumcidin Molecular Formula: C10H11NO Molecular Weight: 161.20 Percent Composition: C 74.51%, H 6.88%, N 8.69%, O 9.93% Literature References: Antiviral antibiotic produced by Streptomyces abikoensis and Streptomyces rubescens. Chromatographic isoln from broth cultures: Umezawa et al., Jpn. …
ブレキサノロン , Brexanolone, Allopregnanolone
It’s only fair to share… Brexanolone 318.501 g/mol, C21H34O2 CAS: 516-54-1 ブレキサノロン MFCD00003677 Pregnan-20-one, 3-hydroxy-, (3α,5α)- Pregnan-20-one, 3-hydroxy-, (3α,5α)- [ACD/Index Name] S39XZ5QV8Y TU4383000 UNII:S39XZ5QV8Y (1S,2S,7S,11S,14S,15S,5R,10R)-14-acetyl-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadecane (+)-3a-Hydroxy-5a-pregnan-20-one (+)-3α-Hydroxy-5α-pregnan-20-one (3α,5α)-3-Hydroxypregnan-20-one [ACD/IUPAC Name] 10446 3211363 [Beilstein] 3a-Hydroxy-5a-pregnan-20-one The U.S. Food and Drug Administration today approved Zulresso (brexanolone) injection for intravenous (IV) use for the treatment of postpartum depression (PPD) in adult women. …
Triclabendazole, トリクラベンダゾール
It’s only fair to share… Triclabendazole トリクラベンダゾール CGA-89317 Formula C14H9Cl3N2OS CAS 68786-66-3 Mol weight 359.6581 Anthelmintic 5-Chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole 68786-66-3 [RN] DD6747000 Fasinex [Trade name] MFCD00864519 [MDL number] APPROVED, Egat, FDA 2019, 02/13/2019 Triclabendazole, sold under the brand name Egaten among others, is a medication used to treat liver flukes, specifically fascioliasisand paragonimiasis.[1] It is very effective for both conditions.[1] Treatment in hospital may be required.[1] It is …
ASP 3026
It’s only fair to share… ASP3026 ASP3026; CAS 1097917-15-1; ASP-3026; ASP 3026; UNII-HP4L6MXF10; N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine; 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine) was developed as a novel selective inhibitor of the fusion protein EML4-ALK. 1H NMR (CDCl3, 400 MHz) (ppm) = 1.31 (d, 6H, J = 6.8 Hz), 1.58–1.80 (m, 4H), 1.90–2.04 (m, 2H), 2.16–2.84 (m, 12H), 3.18–3.32 (m, 1H), 3.66–3.76 …
Cenobamate
It’s only fair to share… Cenobamate CAS: 913088-80-9 Chemical Formula: C10H10ClN5O2 Molecular Weight: 267.67 Related CAS #: 913088-80-9 913087-59-9 Synonym: YKP-3089; YKP3089; YKP3089; Cenobamate IUPAC/Chemical Name: (R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl carbamate 2H-Tetrazole-2-ethanol, α-(2-chlorophenyl)-, carbamate (ester), (αR)- (9CI) (1R)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl carbamate Carbamic acid (R)-(+)-1-(2-chlorophenyl)-2-(2H-tetrazol-2-yl)ethyl ester 2H-Tetrazole-2-ethanol, α-(2-chlorophenyl)-, 2-carbamate, (αR)- Cenobamate, also known as YKP-3089, is a novel new antiepileptic drug candidate. Cenobamate showed …
Rovafovir Etalafenamide
It’s only fair to share… Rovafovir etalafenamide GS-9131 UNII-U8S0IC8DY7 ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate L-Alanine, N-((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydro-2-furanyl)oxy)methyl)phenoxyphosphinyl)-, ethyl ester CAS: 912809-27-9 Chemical Formula: C21H24FN6O6P Molecular Weight: 506.43 Originator Gilead Sciences Class Antiretrovirals; Purine nucleosides; Small molecules Mechanism of Action Nucleoside reverse transcriptase inhibitors Phase II HIV-1 infections 03 Apr 2018 Phase-II clinical trials in HIV-1 infections (Treatment-experienced) in Uganda (PO) (NCT03472326) 21 Mar 2018 Gilead …