BMS-741672

It’s only fair to share… BMS-741672 N-((1R,2S,5R)-5-(Isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide BMS-741672 N-((lR,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6- (trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-l-yl)cyclohexyl)acetamide N-((1R,2S,5R)-5-(isopropyl(methyl)amino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-1-yl)cyclohexyl)acetamide; C25 H33 F3 N6 O2, 506.56 Acetamide, N-[(1R,2S,5R)-5-[methyl(1-methylethyl)amino]-2-[(3S)-2-oxo-3-[[6-(trifluoromethyl)-4-quinazolinyl]amino]-1-pyrrolidinyl]cyclohexyl]- CAS 1004757-96-3 PHASE 2, , Treatment of Type 2 Diabetes, Agents for Neuropathic Pain Chemokine CCR2 (MCP-1 Receptor) Antagonists Molecular Formula: C25H33F3N6O2 Molecular Weight: 506.574 g/mol Michael G. Yang, Robert J. Cherney Original Assignee Bristol-Myers Squibb Company Michael G. Yang, …

Cetilistat, セチリスタット

It’s only fair to share… Cetilistat, セチリスタット Molecular FormulaC25H39NO3 Average mass401.582 Da CAS 282526-98-1 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one 282526-98-1 [RN] 2-Hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one 2-hexadecyl-oxy-6-methyl-4H-3,1-benzoxazin-4-one 4H-3,1-Benzoxazin-4-one, 2-(hexadecyloxy)-6-methyl [282526-98-1] 2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one ATL-962; ATL962;ATL 962 Trade Name:Oblean® MOA:Pancreatic lipase inhibitor Indication:Obesity Status:Approved, 2013-09-20 JAPAN,  Japan PMDA. Company:Norgine (Originator) , Takeda Cetilistat was approved by Pharmaceuticals Medical Devices Agency of Japan (PMDA) on September 20, 2013. It was …

BMS-442608

It’s only fair to share… BMS-442608 8-Azaspiro(4.5)decane-7,9-dione, 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6R)- (6R)-6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione (R)-6-Hydroxybuspirone, UNII-93881477KV, CAS 477930-30-6, Molecular Formula, C21-H31-N5-O3, Molecular Weight, 401.5079 BMS-442608 is a 5-HT1A partial agonist. BMS-442608 is the R-enantiomer. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer. (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the …

BMS-852927

It’s only fair to share… BMS-852927 CAS 256918-39-4 609.51 MW C29 H28 Cl2 F2 N2 O4 S MF 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol 1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-α,α-dimethyl- Treat metabolic syndrome   Brett Busch, Ph.D. https://www.linkedin.com/in/brettbbusch Brett B. Busch, William C. Stevens, Jr., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu,Richard Martin, Raju Mohan Applicant Exelixis, Inc. Brett B. Busch, William C. Stevens, JR., …

WAY-315193

It’s only fair to share…   7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one 7-f luoro-1 -[(1 S,2R)-1 -(3-fluorophenyl)-2-hydroxy-3- (methylamino)propyl]-3,3- dimethyl-1 ,3-dihydro-2H-indol-2-one hydrochloride WAY-315193 7-fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methyl amino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; Molecular Formula: C20H22F2N2O2 Molecular Weight: 360.397686 g/mol 7-Fluoro-1-[(1S,2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethylindolin-2-one Hydrochloride Callain Younghee Kim, Paige Erin Mahaney,Eugene John Trybulski, Puwen Zhang,Eugene Anthony Terefenko, Casey Cameron Mccomas, Michael Anthony Marella, Richard Dale Coghlan, Gavin David Heffernan,Stephen Todd Cohn, An …

CB-618

It’s only fair to share…   CB-618, CB-238618 CAS 1463520-70-8 C8 H10 N4 O6 S, 290.25 Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester (25, 5R)-sulfuric acid mono-(2-[l,3,4]oxadiazol-2-yl-7-oxo-l,6-diaza-bicyclo[3.2.1]oct-6-yl) ester SODIUM SALT sodium salt of (2S,5R)-sulfuric acid mono-(2-[1,3,4]oxadiazol-2-yl-7-oxo-1,6-diaza-bicyclo[3.2.1]oct-6-yl)ester CAS 1628207-16-8 C8 H10 N4 O6 S . Na Sulfuric acid, mono[(1R,2S,5R)-2-(1,3,4-oxadiazol-2-yl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1) PATENTS WO2013149121 US 20140275001 US 20150094472 WO 2016081452 Infection, multidrug …

Register Today for the ACS Symposium in India on Recent Advances in Drug Development, 11-12 November 2016 in Hyderabad, India

It’s only fair to share… Inaugural ACS Industry Symposium, 11-12 November 2016 in Hyderabad, India Recent Advances in Drug Development Register Today for the ACS Symposium in India on Recent Advances in Drug Development To view this email as a web page, go here. Register now for the inaugural ACS Industry Symposium, 11-12 November 2016 …

Ranitidine

It’s only fair to share… Ranitidine Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production.[1] It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.[1] There is also tentative evidence of benefit for hives.[2] It can be taken by mouth, by …

BMS 986001, Censavudine, Festinavir

It’s only fair to share… BMS 986001 Censavudine, Festinavir Has anti-HIV activity. IN PHASE 2 CAS: 634907-30-5, UNII: 6IE83O6NGA, OBP 601, 4′-Ethynyl D4T, 4′-Ed4T, TDK-4-114 Molecular Formula, C12-H12-N2-O4, Molecular Weight, 248.2368 2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine,  1-((2R,5R)-5-Ethynyl-5-(hydroxymethyl)-2H-furan-2-yl)-5-methyl-pyrimidine-2,4-dione,  2′,3′-Didehydro-3′-deoxy-4′-ethynylthymidine INNOVATOR= YALE UNIVERSITY Festinavir is a nucleoside reverse transcriptase inhibitor (NRTI) which is being developed for the treatment of HIV infection. The drug has shown considerable efficacy in …

QbD Presentations

It’s only fair to share… Qbd by Anthony Melvin Crasto for API from Anthony Melvin Crasto Ph.D   Organizational Initiatives Towards Developing Greener Processes for Generic Active Pharmaceutical Ingredients – Dr. Vilas H. Dahanukar, Chief Scientist-Process R&D, Integerated Product Development Organization, Dr. Reddy’s Laboratories Ltd., India presented at 4th Industrial Green Chemistry World Convention & …