Diphenhydramine Hydrochloride, Use of Flow Synthesis

It’s only fair to share… Diphenhydramine Hydrochloride REGULAR SYNTHESIS FLOW SYNTHESIS   Diphenhydramine hydrochloride is the active pharmaceutical ingredient in several widely used medications (e.g., Benadryl, Zzzquil, Tylenol PM, Unisom), and its worldwide demand is higher than 100 tons/year. In 2013, Jamison and co-workers developed a continuous flow process for the synthesis of 3 minimizing waste …

Novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8),

It’s only fair to share… CAS 1620779-53-4 MF C22H20N4O2, MW 372.4 (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide 1H-1,2,3-Triazole-1-acetamide, 5-(2-cyclopropylethynyl)-N-hydroxy-4-phenyl-α-(phenylmethyl)-, (αS)- Applicants: TRUSTEES OF BOSTON UNIVERSITY DANA-FARBER CANCER INSTITUTE, INC. Inventors: Aaron Beaty BEELER John A. PORCO, JR. Oscar J. INGHAM James E. BRADNER As histone proteins bind DNA prior to transcription, their biochemical action plays a critical role in the regulation …

ミチグリニドカルシウム水和物 , Mitiglinide calcium hydrate, 快如妥/Glufast

It’s only fair to share… Mitiglinide MF C19H25NO3 MW 315.407 Da Mitiglinide (INN, trade name Glufast) is a drug for the treatment of type 2 diabetes.[1] Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. …

Duloxetine Hydrochloride, MSN, PATENT, US. 8362279

It’s only fair to share… US. 8362279 http://www.google.co.in/patents/US8362279 Inventors Manne Satyanarayana Reddy, Muppa Kishore Kumar, Srinivasan Thirumalai Rajan,Durgadas Shyla Prasad,  Original Assignee Msn Laboratories Limited Synthesis of duloxetine is described in detail in EP-A-273 658, EP-A-457 559 and EP-A-650965, starting from 2-acetylthiophene, an aminomethylation with dimethylamine and formaldehyde (Mannich reaction) is carried out in step-A. …

CURCUMIN

It’s only fair to share… Curcumin Enol form Keto form Title: Curcumin CAS Registry Number: 458-37-7 CAS Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Additional Names: turmeric yellow; diferuloylmethane; C.I. 75300; C.I. Natural Yellow 3 Molecular Formula: C21H20O6 Molecular Weight: 368.38 Percent Composition: C 68.47%, H 5.47%, O 26.06% Literature References: Natural dyestuff from root of Curcuma longa L., Zingiberaceae. Isoln: Vogel, Ann. 44, 297 (1842); Perkin, Phipps, J. Chem. Soc. (Trans.) 85, I, 64 (1904); Rao, Shintre, J. Soc. …

(±)-SIPI 6360

It’s only fair to share… (±)-SIPI 6360 D2/5-HT2A receptor dual antagonist 7-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methyl-3,4-dihydro-1H-quinolin-2-one 2(1H)-Quinolinone, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3,4-dihydro-3-methyl- Molecular Formula: C25H28FN3O3 Molecular Weight: 437.506523 g/mol CAS 1401333-14-9 2(1H)-Quinolinone, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3,4-dihydro-3-methyl- ((±)-SIPI 6360) 7-(3-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methyl-3,4-dihydroquinolin-2(1H)-one ((±)-SIPI 6360) Mp 154–155 °C; 1H NMR (400 Hz, CDCl3) δ 8.41 (br, 1H), 7.70 (dd, J = 8.8, 5.2 Hz, 1H), 7.27–7.23 (m, 1H), 7.08–7.03 (m, …

REMOGLIFLOZIN ETABONATE

It’s only fair to share… REMOGLIFLOZIN ETABONATE 5-methyl-4-[4-(1-methylethoxy)benzyl]-1-(1-methylethyl)-1H-pyrazol-3-yl 6-O-(ethoxycarbonyl)-β-D-glucopyranoside, ethyl [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxy-oxan-2-yl]methyl carbonate  https://clinicaltrials.gov/show/NCT02537470   UNII:TR0QT6QSUL CAS 442201-24-3 189075  BHV-091009  GSK-189075  GSK-189075A  KGT-1681  BHV Pharma  Kissei (Originator)  , GlaxoSmithKline Remogliflozin etabonate Phase II A SGLT-2 antagonist potentially for the treatment of type 2 diabetes, non-alcoholic steatohepatitis (NASH), obesity. GSK-189075; GSK-189075A Molecular FormulaC26H38N2O9 Average mass522.588 Remogliflozin etabonate (INN/USAN)[1] …

Continuous Flow Doebner–Miller Reaction and Isolation Using Continuous Stirred Tank Reactors

It’s only fair to share… Continuous flow Doebner–Miller synthesis of different quinaldines from respective anilines is demonstrated using sulfuric acid as a homogeneous catalyst. The extent of reaction was monitored for various parameters, namely, temperature, residence time, mole ratio of sulfuric acid to substrate, mole ratio of crotonaldehyde to substrate, and so forth. Continuous stirred …

Pharma Marketing Conference- Its need of the Hour!, “Pharma Marketing Summit 2016” 13-14 Oct 2016, Holiday Inn Mumbai International Airport, Mumbai, India

It’s only fair to share… Pharma Marketing Conference- Its need of the Hour!, “Pharma Marketing Summit 2016” 13-14 Oct 2016, Holiday Inn Mumbai International Airport, Mumbai, India Today, it’s not only about promoting your products but to position your company as a disease prevention and management company. The regulatory environment in the pharmaceutical sector is …

Olanexidine, オラネキシジングルコン酸塩

It’s only fair to share… Olanexidine Gluconate OPB-2045G, Gluconate olanexidin,  Olanedine,  OPB-2045,  OPB 2045G,  (Olanedine®)Approved in Japan PMDA 2015-07-03, Olanedine® by Otsuka A disinfectant used to prevent of postoperative bacterial infections. CAS .146510-36-3(Olanexidine free form),  Imidodicarbonimidic diamide, N-((3,4-dichlorophenyl)methyl)-N’-octyl C17H27Cl2N5 Formula Weight: 372.341 CAS 799787-53-4(Olanexidine Gluconate) 568.49 Formula C17H27Cl2N5 ● C6H12O7 1-(3,4-Dichlorobenzyl)-5-octylbiguanide mono-D-gluconate オラネキシジングルコン酸塩 Olanexidine Gluconate C17H27Cl2N5▪C6H12O7 : 568.49 [799787-53-4] Indication:Bacterial infection …