ADRAFINIL

It’s only fair to share… ADRAFINIL 2-((diphenylmethyl)sulfinyl)-acetohydroxamicaci;2-((diphenylmethyl)sulfinyl)-n-hydroxy-acetamid;2-((diphenylmethyl)sulfinyl)-n-hydroxyacetamide;2-(benzhydrylsulfinyl)acetohydroxamicacid;ADRAFINIL;2-[(DIPHENYLMETHYL)SULFINYL]ACETOHYDROXAMIC ACID;CRL 40028;OLMIFON CAS 63547-13-7 MF:C15H15NO3S MW:289.35 EINECS:264-303-1 WATCH THIS POST AS DETAILS LIKE SYNTHESIS ARE UPDATED…………. Adrafinil is touted mainly for its stimulant properties and ability to provide alertness and wakefulness. Stay up late/stay awake during normal sleeping hours: Adrafinil may be helpful for night workers who need a …

ZINPLAVA (BEZLOTOXUMAB), Approved FDA

It’s only fair to share… BEZLOTOXUMAB Biologic License Application (BLA): 761046 Company: MERCK SHARP DOHME Drug Name(s): • ZINPLAVA (BEZLOTOXUMAB) http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/761046s000lbl.pdf http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2016/761046Orig1s000ltr.pdf Drug Name Active Ingredient Approval Date FDA-approved use on approval date Zinplava bezlotoxumab 10/21/2016 To reduce the recurrence of Clostridium difficile infection in patients aged 18 years or older Drug Trials Snapshot From Wikipedia, …

NEW PATENT, WO2016178162, TENOFOVIR, CBZ INVESTMENTS LTD.

It’s only fair to share… NEW PATENT WO2016178162,  SYNTHESIS OF INTERMEDIATES USED IN THE MANUFACTURE OF ANTI-HIV AGENTS CBZ INVESTMENTS LTD. [–/GB]; 122, Feering Hill, Feering, Colchester, Essex CO5 9PY (GB) PRADHAN, Braja Sundar; (IN). AMARNATH, Kommireddy; (IN). VEMPALA, Naresh; (IN). RAHMAN, Md. Ataur; (IN)   PRADHAN, Braja Sundar Process for preparing 9-[2-(hydroxyl)propyl]adenine and 9-[2-phosphonomethoxypropyl]adenine, …

Sacubitril

It’s only fair to share… Sacubitril, AHU 377 NEPRILYSIN INHIBITOR FOR HEART FAILURE CAS 149709-62-6 CAS SODIUM SALT 149690-05-1 (2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid ethyl ester 5-(Biphenyl-4-yl)-4(S)-(3-carboxypropionamido)-2(R)-methylbutyric acid ethyl ester N-(3-carboxy-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-2R-methyl butanoic acid ethyl ester [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αR,γS)- [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, ethyl ester, [S-(R*,S*)]- (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester Formula C24H29NO5 MW 411.49 …

LUPIN LIMITED, WO 2016181313, NEW PATENT, SOFOSBUVIR

It’s only fair to share… WO2016181313,  A PROCESS FOR THE PREPARATION OF SOFOSBUVIR INTERMEDIATES & ITS POLYMORPH LUPIN LIMITED [IN/IN]; Kalpataru Inspire 3rd Floor, Off Western Express Highway Santacruz (East) Mumbai 400 055 (IN) SINGH, Girij, Pal; (IN). SRIVASTAVA, Dhananjai; (IN). MEHARE, Kishor, Gulabrao; (IN). MALIK, Vineet; (IN). DEOKAR, Sharad, Chandrabhan; (IN). DANGE, Abhijeet, Avinash; …

SUVEN LIFE SCIENCES LTD, WO 2016178064, POLYMORPH OF NINTEDANIB ETHANESULPHONATE, NEW PATENT

It’s only fair to share… NINTEDANIB ETHANESULPHONATE NEW PATENT WO2016178064, CLICK FOR PATENT POLYMORPH OF NINTEDANIB ETHANESULPHONATE, PROCESSES AND INTERMEDIATES THEREOF SUVEN LIFE SCIENCES LIMITED [IN/IN]; 5th floor, Serene Chamber, Road No.5, Off Avenue No. 7, Banjara Hills, Telangana Hyderabad 500034 (IN) ARAVA, Veera Reddy; (IN). GOGIREDDY, Surendra Reddy; (IN). JASTI, Venkateswarlu; (IN) DR VEERA …

Filgotinib

It’s only fair to share… Filgotinib C21H23N5O3S MW425.504 Elemental Analysis: C, 59.28; H, 5.45; N, 16.46; O, 11.28; S, 7.54 1206161-97-8 Cyclopropanecarboxamide, N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]- G146034 GLPG0634 N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide Galapagos Nv INNOVATOR IL-6 antagonist; Jak1 tyrosine kinase inhibitor; Tyk2 tyrosine kinase inhibitor; Jak3 tyrosine kinase inhibitor; Jak2 tyrosine kinase inhibitor Autoimmune disease; Cancer; Colitis; Crohns disease; Inflammatory disease; Neoplasm; …

Pexidartinib, PLX-3397

It’s only fair to share… Pexidartinib PLX-3397 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine 5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine hydrochloride Phase III A Multi-targeted tyrosine kinase inhibitor potentially for the treatment of tenosynovial giant cell tumor (TGCT). CAS 1029044-16-3 C20H15ClF3N5, 417.81 Pexidartinib; 1029044-16-3; PLX-3397; 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine; 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine; 5-[(5-Chloro-1h-Pyrrolo[2,3-B]pyridin-3-Yl)methyl]-N-{[6-(Trifluoromethyl)pyridin-3-Yl]methyl}pyridin-2-Amine; Originator Plexxikon Developer Barbara Ann Karmanos Cancer Institute; Columbia University; Merck & Co; National Cancer Institute (USA); Plexxikon; University …

VALSARTAN

It’s only fair to share… VALSARTAN CAS 137862-53-4 Molecular FormulaC24H29N5O3, Average mass435.519 Da (2S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid PAPER Greening the Valsartan Synthesis: Scale-up of Key Suzuki–Miyaura Coupling over SiliaCat DPP-Pd Valerica Pandarus †, Delphine Desplantier-Giscard†, Geneviève Gingras , François Béland †*, Rosaria Ciriminna ‡, and Mario Pagliaro ‡* † SiliCycle Inc., 2500 Parc-Technologique Blvd, Quebec City, Quebec, Canada G1P 4S6 ‡ Istituto per lo Studio dei Materiali Nanostrutturati, CNR, via …