It’s only fair to share… SK1-I , BML 258 Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative (1E)-1,2,4-Trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol (E,2R,3S)-2-(Methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diol D-erythro-Pent-1-enitol, 1,2,4-trideoxy-4-(methylamino)-1-(4-pentylphenyl)-, (1E)- Name: (2R,3S,4E)-N-methyl-5-(4′-pentylphenyl)-2-aminopent-4-ene-1,3-diol . HCl Formula: C17H27NO2 . HCl MW: 313.9 CAS: 1072443-89-0 Originator Enzo Biochem; Virginia Commonwealth University Developer Enzo Biochem Class Antineoplastics; Small molecules Mechanism of Action Sphingosine kinase inhibitors Preclinical Autoimmune hepatitis; Haematological malignancies; Liver cancer; Solid tumours …
Verubecestat Impurity 10
It’s only fair to share… Verubecestat Verubecestat Impurity 10 1H NMR (600 MHz, Acetonitrile-d3) δ 9.86 (s, 1H), 8.21 (d, J = 3.0 Hz, 1H), 8.02 (dd, J = 7.5, 2.8 Hz, 1H), 7.96 (d, J = 8.9 Hz, 1H), 7.81 (ddd, J = 8.7, 4.2, 2.7 Hz, 1H), 7.24 (dd, J = …
PF 04965842, Abrocitinib
It’s only fair to share… PF-04965842 PF 04965842, Abrocitinib UNII: 73SM5SF3OR CAS Number 1622902-68-4, Empirical Formula C14H21N5O2S, Molecular Weight 323.41 N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide, N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide 1-Propanesulfonamide, N-(cis-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)cyclobutyl)- N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide PHASE 3, for the potential oral treatment of moderate-to-severe atopic dermatitis (AD) Jak1 tyrosine kinase inhibitor THE US In February 2018, the FDA granted Breakthrough Therapy designation for the treatment of patients with moderate-to-severe …
Ritlectinib, PF 06651600
It’s only fair to share… Ritlectinib PF-06651600 CAS 1792180-81-4 C₁₅H₁₉N₅O, 285.34, UNII-2OYE00PC25 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate PF-06651600 malonate CAS: 2140301-97-7 (malonate) Chemical Formula: C18H23N5O5 Molecular Weight: 389.412 PHASE 2 alopecia areata, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. PF-06651600 is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo …
SYN-01
It’s only fair to share… SYN-01, SYN-510 Synthena AG Preclinical Synthena , presumed to be under license from University of Bern , is investigating (presumably SYN-01 ), a lead from the tricyclo(tc)-DNA based antisense oligonucleotides (AON) developed using its proprietary tricyclo-DNA technology platform, for the treatment of Duchenne muscular dystrophy. In January 2017, …
LK-01, Apomorphine
It’s only fair to share… LK-01 Leukos Biotech S.L. APL-130277, H-001, Apokyn (-)-10,11-dihydroxyaporphine (-)-Apomorphine (6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (R)-(-)-Apomorphine (R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol 200-360-0 [EINECS] 41372-20-7 [RN] 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)- 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)- 6ab-Aporphine-10,11-diol R-(-)-Apomorphine Apomorphine CAS Registry Number: 58-00-4 CAS Name: (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol Additional Names: 6ab-aporphine-10,11-diol Molecular Formula: C17H17NO2 Molecular Weight: 267.32 Percent Composition: C 76.38%, H 6.41%, N 5.24%, O 11.97% Literature References: Dopamine (D1 and D2) receptor agonist. Synthetic opiate obtained by …
SY-008
It’s only fair to share… SY-008 CAS 1878218-66-6 FREE FORM 1480443-32-0 SGLT1 inhibitor (type 2 diabetes), β-D-Glucopyranoside, 4-[[4-[(1E)-4-(2,9-diazaspiro[5.5]undec-2-yl)-1-buten-1-yl]-2-methylphenyl]methyl]-5-(1-methylethyl)-1H-pyrazol-3-yl, acetate (1:1) acetic acid;(2S,3R,4S,5S,6R)-2-[[4-[[4-[(E)-4-(2,9-diazaspiro[5.5]undecan-2-yl)but-1-enyl]-2-methylphenyl]methyl]-5-propan-2-yl-1H-pyrazol-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 4-{4-[(1E)-4-(2,9-diazaspiro[5.5]undec-2-yl)but-1-en-1-yl]-2-methylbenzyl}-5-(propan-2-yl)-1H-pyrazol-3-yl beta-D-glucopyranoside acetate MF H50 N4 O6 . C2 H4 O2 MW 58.8 g/mol,C35H54N4O8 Originator Eli Lilly Developer Eli Lilly; Yabao Pharmaceutical Group Class Antihyperglycaemics; Small molecules Mechanism of Action Sodium-glucose transporter 1 inhibitors Phase I Diabetes mellitus 28 Aug 2018 No recent reports of …
Fasoracetam
It’s only fair to share… Fasoracetam Molecular FormulaC10H16N2O2 Average mass196.246 Da (5R)-5-(1-Piperidinylcarbonyl)-2-pyrrolidinone (5R)-5-(Piperidin-1-ylcarbonyl)pyrrolidin-2-one 110958-19-5 [RN] 2-Pyrrolidinone, 5-(1-piperidinylcarbonyl)-, (5R)- 7708, UNII: 42O8UF5CJB NS 105 N-(5-Oxo-D-prolyl)piperidine (+)-1-(((R)-5-Oxo-2-pyrrolidinyl)carbonyl)piperidine AEVI GENOMIC MEDICINE, INC. [US/US]; 435 Devon Park Drive, Suite 715 Wayne, Pennsylvania 19087, US Fasoracetam is a research chemical of the racetam family.[3] It is a putative nootropic that failed to show sufficient efficacy in clinical trials for vascular dementia. It is currently being …
BQ-788
It’s only fair to share… BQ-788 Molecular FormulaC34H50N5NaO7 Average mass663.780 Da SP ROT +3.8 ° Conc: 1.032 g/100mL; methanol; Wavlenght: 589.3 nm, Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues Peptides (New York, NY, United States) (2005), 26, (8), 1441-1453., https://doi.org/10.1016/j.peptides.2005.03.022 FOR FREE FORM +19.6 °, Conc: 0.998 …
Fluazolepali, 氟唑帕利 , Fluzoparib
It’s only fair to share… Fluazolepali CAS 2170504-09-1 Fluzoparib; SHR-3162, (HS10160) HS 10160 SHR 3162 An orally available inhibitor of poly(ADP-ribose) polymerase 1 and 2 (PARP-1/2) for treatment of solid tumors (Jiangsu Hengrui Medicine Co. Ltd., Lianyungang, China) Fluazolepali, developed by Hengrui and Howson, is intended for the treatment of recurrent ovarian cancer, triple-negative breast …