It’s only fair to share… Thiotepa, チオテパ Use:antineoplastic, alkylating agent Chemical name:1,1′,1”-phosphinothioylidynetrisaziridine Formula:C6H12N3PS MW:189.22 g/mol CAS:52-24-4 EINECS:200-135-7 LD50:14500 μg/kg (M, i.v.); 38 mg/kg (M, p.o.); 9400 μg/kg (R, i.v.) Aziridine, 1,1′,1”-phosphinothioylidynetris- Aziridine, 1-[bis(1-aziridinyl)phosphinothioyl]- N,N’,N”-Triethylenethiophosphoramide Phosphorothioic tri(ethyleneamide) SZ2975000 T3NTJ APS&- AT3NTJ&– AT3NTJ [WLN] Thiofozil Thiotef 1,1′,1”-Phosphorothioyltriaziridine JAPAN APPROVED, Rethio, PMDA, 2019/3/26 тиотепа [Russian] [INN] ثيوتيبا [Arabic] [INN] 塞替派 [Chinese] [INN] Thiotepa (INN,[1] chemical name: N,N′,N′′-triethylenethiophosphoramide) is an alkylating agent used …
Peficitinib hydrobromide, ペフィシチニブ臭化水素酸塩
It’s only fair to share… Peficitinib hydrobromide ペフィシチニブ臭化水素酸塩 ASP015K, Rheumatoid Arthritis 1H-Pyrrolo(2,3-b)pyridine-5-carboxamide, 4-((5-hydroxytricyclo(3.3.1.13,7)dec-2-yl)amino)-, hydrobromide (1:1), stereoisomer 4-{[(1R,2s,3S,5r)-5-Hydroxyadamantan-2-yl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide (1:1) 1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[[(1R,3S)-5-hydroxytricyclo[3.3.1.13,7]dec-2-yl]amino]-, hydrobromide (1:1) U55XHZ5X6P Formula C18H22N4O2. HBr CAS 1353219-05-2 HBR 944118-01-8 BASE Mol weight 407.3048 PMDA, 2019/3/26 JAPAN APPROVED, Smyraf Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis Peficitinib (formerly known as ASP015K) is …
Cefamandole, セファマンドール ,цефамандол , سيفاماندول , 头孢孟多 ,
It’s only fair to share… Cefamandole セファマンドール цефамандол [Russian] [INN] سيفاماندول [Arabic] [INN] 头孢孟多 [Chinese] [INN] CAS Registry Number: 34444-01-4 CAS Name: (6R,7R)-7-[[(2R)-Hydroxyphenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Additional Names: 7-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-D-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid; 7-D-mandelamido-3-(1-methyl-1,2,3,4-tetrazole-5-thiomethyl)-D3-cephem-4-carboxylic acid; CMT Manufacturers’ Codes: compd 83405 Molecular Formula: C18H18N6O5S2 Molecular Weight: 462.50 Percent Composition: C 46.74%, H 3.92%, N 18.17%, O 17.30%, S 13.87% Literature References: Broad-spectrum semi-synthetic cephalosporin antibiotic. Prepn: C. W. Ryan, DE 2018600; idem, US3641021 (1970, 1972 to Lilly); …
VIXOTRIGINE, NEW PATENT, WO-2019071162, BIOGEN INC
It’s only fair to share… VIXOTRIGINE, NEW PATENT, WO-2019071162, BIOGEN INC https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019071162&redirectedID=true vixotrigine Process for preparing α-carboxamide pyrrolidine derivatives (particularly vixotrigine ) and its intermediates are modulators of use-dependent voltage-gated sodium channels Biogen, following the acquisition of Convergence Pharmaceuticals, that previously acquired clinical assets from GSK is developing vixotrigine a voltage-gated sodium channel 1.7 inhibitor, for the …
Tegaserod, テガセロド
It’s only fair to share… Tegaserod Molecular FormulaC16H23N5O Average mass301.387 Da テガセロド 145158-71-0 cas HTF 919 / HTF-919 / SDZ HTF 919 / SDZ-HTF-919 N’-[(E)-[(5-methoxy-1H-indol-3-yl)methylidene]amino]-N-pentylguanidine (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide [ACD/IUPAC Name] (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N’-pentylhydrazinecarboximidamide (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide 145158-71-0 [RN] 7606 Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E) Sundaram Venkataraman, Srinivasulu Gudipati, Brahmeshwararao Mandava Venkata Naga, Goverdhan Banda, Radhakrishna Singamsetty, “Process for preparing form I of tegaserod maleate.” U.S. Patent US20050272802, issued December 08, 2005.US20050272802 Tegaserod …
BMS-986236
It’s only fair to share… BMS-986236 CAS 2058035-15-5 MW C22 H25 N9 O MF 431.49 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile, 1-[5-[4-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl]-4-[(1-methylethyl)amino]-2-pyridinyl]- 1-[5-[4-(3-hydroxy-3-methylbutyl)triazol-1-yl]-4-(propan-2-ylamino)pyridin-2-yl]pyrazolo[3,4-b]pyridine-5-carbonitrile The present invention generally relates to heteroaryl substituted aminopyridine compounds useful as kinase inhibitors, including the modulation of IRAK-4. Provided herein are heteroaryl substituted aminopyridine compounds, compositions comprising such compounds, and methods of their use. The invention further pertains to …
TAK-981
It’s only fair to share… TAK-981 C25 H28 Cl N5 O5 S2, 578.103 [(1R,2S,4R)-4-[(5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl)amino]-2-hydroxycyclopentyl]methyl sulfamate [(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-thiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxy-cyclopentyl]methyl sulfamate Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester CAS 1858276-04-6 FREE CAS 1858279-63-6 HYDRATE MW 578.103 Originator Takeda Oncology Class Antineoplastics Mechanism of Action Small ubiquitin-related modifier protein inhibitors Phase I Lymphoma; Solid tumours 01 Oct 2018 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease) and and Lymphoma …
BIIB-095
It’s only fair to share… BIIB-095 ROTATION (+) 1493790-64-9 CAS free form, 1493772-48-7 cas Hcl salt cas 1493790-65-0, 1496563-32-6 ,SULPHATE ??? cas 1496563-31-5 SULFATE 1;1 cas 1496563-32-6 SULFATE HYDRATE 1;1;1 (2R,5S)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1 ,7-diazaspiro[4.4]nonan-6-one 1,7-Diazaspiro[4.4]nonan-6-one, 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]-2-pyrimidinyl]-, (2R,5S)- C20 H21 F3 N4 O, 390.40 Originator Biogen Class Analgesics Mechanism of Action Nav1.7 voltage-gated sodium channel inhibitors Phase I Neuropathic pain 29 Mar 2018 Phase-I clinical trials in Neuropathic pain (In volunteers) in …
VNRX-7145
It’s only fair to share… CAS 1842399-68-1 MF C19 H26 B N O7 MW 391.22 2H-1,2-Benzoxaborin-8-carboxylic acid, 3,4-dihydro-2-hydroxy-3-[(1-oxopropyl)amino]-, (2-ethyl-1-oxobutoxy)methyl ester, (3R)- The VNRX-7145 combination is now in Phase I studies to treat resistant urinary tract infections. VNRX-7145 PATENT WO 2015191907 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015191907 ntibiotics are the most effective drugs for curing bacteria-infectious diseases clinically. They have a wide market due to …
Acefylline
It’s only fair to share… Acefylline Molecular FormulaC9H10N4O4 Average mass238.200 Da (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic Acid 1,3-Dimethylxanthine-7-acetic acid 211-490-2 [EINECS] 652-37-9 [RN] 7-(Carboxymethyl)theophylline 7H-Purine-7-acetic acid, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo- CAS Registry Number: 652-37-9 CAS Name: 1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxopurine-7-acetic acid Additional Names: carboxymethyltheophylline; 7-theophyllineacetic acid Molecular Formula: C9H10N4O4 Molecular Weight: 238.20 Percent Composition: C 45.38%, H 4.23%, N 23.52%, O 26.87% Literature References: Prepn: DE 352980 (1922 to E. Merck); Frdl. 14, 1320; S. M. Ride et al., Pharmazie 32, 672 (1977). …