It’s only fair to share… Zorifertinib AZD 3759 CAS 1626387-80-1, 67SX9H68W2 WeightAverage: 459.91Monoisotopic: 459.1473455 Chemical FormulaC22H23ClFN5O3 [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate China 2024, APPROVALS 2024, Alpha Biopharma, ASTRA ZENECA, Zorifer, Zorifertinib (AZD3759) is a drug for the treatment of cancer.[1] In China, it was approved in 2024 for locally advanced or metastatic non-small-cell lung cancer (NSCLC) that has epidermal growth factor receptor exon 19 …
Garsorasib
It’s only fair to share… Garsorasib Chemical Formula: C32H32F2N8O2 Exact Mass: 598.2616 Molecular Weight: 598.66 D 1553, Chia Tai Tianqing, CHINA 2024, APPROVALS 2024, Anfangning, Garsorasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, garsorasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. …
Fulzerasib
It’s only fair to share… Fulzerasib GFH925 CAS No. : 2641747-54-6 Molecular Weight 617.07 Formula C32H30ClFN6O4 (7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-9-methyl-12-(4-methyl-2-propan-2-ylpyridin-3-yl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione (7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-9-methyl-12-(4-methyl-2-propan-2-ylpyridin-3-yl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione CHINA 2024, APPROVALS 2024, Innovent Biologics, DUPERT Fulzerasib (Dupert®; Innovent Biologics/GenFleet Therapeutics) is an orally active small molecule inhibitor of the KRAS G12C mutant protein being developed for the treatment of solid tumors harboring the KRAS G12C oncogenic …
Golidocitinib
It’s only fair to share… Golidocitinib CAS 2091134-68-6 WeightAverage: 489.584Monoisotopic: 489.260071274 Chemical FormulaC25H31N9O2 (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide Approvals 2024, china 2024, DZD 4205, DIZAL, Gao Ruizhe, Golidocitinib is a pharmaceutical drug for the treatment of cancer. In June 2024, it was given conditional approval in China for the treatment of relapsed or refractory peripheral T-cell lymphoma.[1] Golidocitinib is classified as …
Oritinib
It’s only fair to share… Oritinib CHINA 2024, Nanjing Sanhome Pharmaceutical. N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide Oritinib is an investigational new drug currently under investigation for its potential use in cancer treatment.[1][2] As a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, oritinib targets specific enzymes involved in the signaling pathways that regulate cell division and survival, which are often dysregulated in cancer cells.[1] Oritinib (SH-1028), …
Envonalkib
It’s only fair to share… Envonalkib TQ-B3139, Chia Tai Tianqing, Anluoqing, cancer ENVONALKIB is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication. SYN WO2014117718 https://patentscope.wipo.int/search/en/WO2014117718 Example 27: 5-[(2,6-dichloro-3-fluorophenyl)ethoxy-4′-methoxy-6′ … Step 1: 5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-4′-methoxy-6′-((S)-2-methyl-4-tert-butoxycarbonylpiperazin-1-yl)-3,3′-bipyridin-6-amine To dioxane (10 mL) and water (1.5 mL) were added tert-butyl (S)-4-(5-bromo-4-methoxypyridin-2-yl)-3-methylpiperidin-1-carboxylate (106 mg, …
Brensocatib
It’s only fair to share… Brensocatib WeightAverage: 420.469Monoisotopic: 420.179755269 Chemical FormulaC23H24N4O4 (2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide FDA 8/12/2025. Brinsupri, To treat non-cystic fibrosis bronchiectasis Brensocatib is an investigational new drug that is being evaluated to treat bronchiectasis.[1] It is a dipeptidyl-peptidase I (also known as cathepsin C) inhibitor.[2] A phase 3 clinical trial, known as the ASPEN trial, was conducted to evaluate the safety and efficacy of …
Unecritinib
It’s only fair to share… Unecritinib 492.4 g/mol, C23H24Cl2FN5O2 N-[3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-yl]acetamide Chia Tai Tianqing Pharmaceutical Group Unecritinib is an orally available, small molecule inhibitor of the receptor tyrosine kinases anaplastic lymphoma kinase (ALK), C-ros oncogene 1 (ROS1) and Met (hepatocyte growth factor receptor; HGFR; c-Met), with potential antineoplastic activity. Upon oral administration,unecritinib targets, binds to and inhibits the activity …
ETINOSTAT
It’s only fair to share… Entinostat Also known as: ms-275, 209783-80-2, SNDX-275, MS 275, MS-27-275, SNDX 275, NSC-706995, BAY 86-5274 BAY86-5274 Molecular Formula: C21H20N4O3 Molecular Weight: 376.4085 g/mol pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]- benzamide CAS 209783-80-2 209784-80-5 (HCl) Bayer Schering Pharma Aktiengesellschaft Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate Entinostat, developed by Syndax Pharmaceuticals, is an oral selective histone deacetylase (HDAC) inhibitor …
Dordaviprone
It’s only fair to share… Dordaviprone WeightAverage: 386.499Monoisotopic: 386.210661473 Chemical FormulaC24H26N4O 11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one Product Ingredients Ingredient UNII CAS InChI Key Dordaviprone dihydrochloride 53VG71J90J 1638178-82-1 Not applicable FDA 8/6/2025, Modeyso, To treat diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy Dordaviprone, sold under the brand name Modeyso is an anti-cancer medication used for the treatment …