Drug Approvals International – Page 74 – All about Drugs Live by Dr Anthony Melvin Crasto

DASATINIB

DASATINIB ダサチニブ水和物 BMS 354825 863127-77-9 HYDRATE, USAN, BAN INN, JAN UNII: RBZ1571X5H 302962-49-8 FREE FORM Dasatinib anhydrous USAN, INN Molecular Formula, C22-H26-Cl-N7-O2-S.H2-O, Molecular Weight, 506.0282 T6N DNTJ A2Q D- DT6N CNJ B1 FM- BT5N CSJ DVMR BG F1 [WLN] X78UG0A0RN дазатиниб [Russian] [INN] دازاتينيب [Arabic] [INN] 达沙替尼 [Chinese] [INN] 1132093-70-9 [RN] 302962-49-8 [RN] 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]- 8712 9966762 [Beilstein] A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE …

Norepinephrine bitartrate

Norepinephrine bitartrate Arterenol bitartrate RN: 3414-63-9 FREE FORM 138-65-8 UNIIIFY5PE3ZRW R FORM CAS Number108341-18-0, 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt), monohydrate 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt), monohydrate (9CI) Arterenol, tartrate, monohydrate (6CI) L-Noradrenaline bitartrate monohydrate Levarterenol bitartrate monohydrate WeightAverage: 337.281 Chemical FormulaC12H19NO10 (+-)-Arterenol bitartrate (+-)-Noradrenaline bitartrate (+-)-Norepinephrine bitartrate (2R,3R)-2,3-dihydroxybutanedioic acid 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol hydrate ORD +41.3 °, water, 4% ; Wavlen: …

COVAXIN, BBV 152

COVAXIN CAS 2501889-19-4 Whole-Virion Inactivated SARS-CoV-2 Vaccine UNII76JZE5DSN6 BBV 152 A whole virion inactivated COVID-19 vaccine candidate derived from SARS-CoV-2 strain NIV-2020-770 REF medRxiv (2020), 1-21. bioRxiv (2020), 1-32. BBV152 (also known as Covaxin) is an inactivated virus-based COVID-19 vaccine being developed by Bharat Biotech in collaboration with the Indian Council of Medical Research. BBV152 is a vaccine candidate created by the Indian Council of Medical Research (ICMR). …

Lenalidomide hydrate

Lenalidomide hydrate レナリドミド水和物 An immunomodulator. CC-5013 hemihydrate 2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, hydrate (2:1) (+/-)-2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, hydrate (2:1) Formula (C13H13N3O3)2. H2O CAS 847871-99-2 Mol weight 536.5365 EMA APPROVED 2021/2/11, Lenalidomide KRKA Research Code：CDC-501; CC-5013 Trade Name：Revlimid® MOA：Angiogenesis inhibitor Indication：Myelodysplastic syndrome (MDS); Mantle cell lymphoma (MCL); Multiple myeloma (MM) Status：Approved Company：Celgene (Originator) Sales：$5,801.1 Million (Y2015); $4,980 Million (Y2014);; $4280 Million (Y2013);; $3766.6 Million (Y2012);; …

Lisocabtagene maraleucel

Lisocabtagene maraleucel (liso-cel; JCAR017; Anti-CD19 CAR T-Cells) is an investigational chimeric antigen receptor (CAR) T-cell therapy designed to target CD19, [1][2] which is a surface glycoprotein expressed during normal B-cell development and maintained following malignant transformation of B cells. [3][4][5] Liso-cel CAR T-cells aim to target and CD-19 expressing cells through a CAR construct that includes an anti-CD19 single-chain …

Casimersen

Casimersen カシメルセン; RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2’a→5′)(C-A-A-m5U-G-C-C-A-m5U-C-C-m5U-G-G-A-G-m5U-m5U-C-C-m5U-G), 5′-[P-[4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]carbonyl]-1-piperazinyl]-N,N-dimethylphosphonamidate] Formula C268H424N124O95P22 CAS 1422958-19-7 Mol weight 7584.4307 FDA 2021/2/25 , Amondys 45, Antisense oligonucleotide Treatment of Duchenne muscular dystrophy Nucleic Acid Sequence Sequence Length: 224 a 7 c 5 g 6 umodified Exon-45: NG-12-0064 SRP-4045 WHO 10354 Casimersen, sold under the brand name Amondys 45, is an antisense oligonucleotide medication used for the treatment of Duchenne muscular …

Fosdenopterin hydrobromide

Fosdenopterin hydrobromide FDA APPR 2021/2/26, NULIBRY BBP-870/ORGN001 a cyclic pyranopterin monophosphate (cPMP) substrate replacement therapy, for the treatment of patients with molybdenum cofactor deficiency (MoCD) Type A. ホスデノプテリン臭化水素酸塩水和物; Formula C10H14N5O8P. 2H2O. HBr CAS 2301083-34-9DIHYDRATE Mol weight 480.1631 2301083-34-9 (1R,10R,12S,17R)-5-amino-11,11,14-trihydroxy-14-oxo-13,15,18-trioxa-2,4,6,9-tetraza-14λ5-phosphatetracyclo[8.8.0.03,8.012,17]octadeca-3(8),4-dien-7-one;dihydrate;hydrobromide 1,3,2-DIOXAPHOSPHORINO(4′,5′:5,6)PYRANO(3,2-G)PTERIDIN-10(4H)-ONE, 8-AMINO-4A,5A,6,9,11,11A,12,12A-OCTAHYDRO-2,12,12-TRIHYDROXY-, 2-OXIDE, HYDROBROMIDE, HYDRATE (1:1:2), (4AR,5AR,11AR,12AS)- CYCLIC PYRANOPTERIN MONOPHOSPHATE MONOHYDROBROMIDE DIHYDRATE (4aR,5aR,11aR,12aS)-8-Amino-2,12,12-trihydroxy-4a,5a,6,7,11,11a,12,12aoctahydro-2H-2lambda5-(1,3,2)dioxaphosphinino(4′,5′:5,6)pyrano(3,2-g)pteridine-2,10(4H)-dione, hydrobromide (1:1:2) 1,3,2-Dioxaphosphorino(4′,5′:5,6)pyrano(3,2-g)pteridin-10(4H)-one, 8-amino-4a,5a,6,9,11,11a,12,12a-octahydro-2,12,12-trihydroxy-, …

Melphalan flufenamide hydrochloride

.HCl Melphalan flufenamide hydrochloride メルファランフルフェナミド塩酸塩; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-L-phenylalanyl-4-fluoro-, ethyl ester, hydrochloride Formula C24H30Cl2FN3O3. HCl CAS 380449-54-7 Mol weight 534.8786 FDA APPROVED PEPAXTO, 2021/2/26 Efficacy Antineoplastic, Alkylating agent Disease Multiple myeloma Ethyl (2S)-2-[(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanamido]-3-(4-fluorophenyl)propanoate J 1 J 1 (prodrug) L-Melphalanyl-L-p-fluorophenylalanine ethyl ester Melflufen Melphalan flufenamide Pepaxto Prodrug J 1 Melflufen Molecular FormulaC24H30Cl2FN3O3 Average mass498.418 Da SP ROT +33.0 ° Conc: …

AZD1222 (ChAdOx1), Oxford–AstraZeneca COVID-19 vaccine, COVISHIELD

AZD1222 (ChAdOx1) Identifiers CAS Number 2420395-83-9 ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant) COVISHIELD™ DNA (recombinant simian adenovirus Ox1 ΔE1E3 vector human cytomegalovirus promoter plus human tissue plasminogen activator signal peptide fusion protein with severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1 spike glycoprotein codon optimized-specifying) The University of Oxford, AstraZeneca vaccine is a vaccine that …

Pyridostigmine

Pyridostigmine Molecular FormulaC9H13N2O2 Average mass181.211 Da 155-97-5 [RN] 3-[(Dimethylcarbamoyl)oxy]-1-methylpyridinium 3-Dimethylcarbamoyloxy-1-methyl-pyridinium 5-21-02-00078 (Beilstein Handbook Reference) [Beilstein] Pyridostigmine Bromide CAS Registry Number: 101-26-8 CAS Name: 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide Additional Names: 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate; 1-methyl-3-hydroxypyridinium bromide dimethylcarbamate; 3-(dimethylcarbamyloxy)-1-methylpyridinium bromide Manufacturers’ Codes: Ro-1-5130 Trademarks: Kalymin (Temmler); Mestinon (Roche); Regonol (Organon) Molecular Formula: C9H13BrN2O2 Molecular Weight: 261.12 Percent Composition: C 41.40%, H 5.02%, Br 30.60%, N 10.73%, O 12.25% Literature References: Reversible …