It’s only fair to share… FDA approves new targeted treatment for relapsed or refractory acute myeloid leukemia 08/01/2017 The U.S. Food and Drug Administration today approved Idhifa (enasidenib) for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation. The drug is approved for use with …
Eravacycline
It’s only fair to share… Eravacycline http://www.ama-assn.org/resources/doc/usan/eravacycline.pdf 1-Pyrrolidineacetamide, N-[(5aR,6aS,7S,10aS)-9-(aminocarbonyl)-7-(dimethylamino)- 4-fluoro-5,5a,6,6a,7,10,10a,12-octahydro-1,8,10a,11-tetrahydroxy-10,12-dioxo-2- naphthacenyl]- (4S,4aS,5aR,12aS)-4-(dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9- [(pyrrolidin-1-ylacetyl)amino]-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 1207283-85-9 CAS 1334714-66-7 dihydrochloride TP 434-046 1-Pyrrolidineacetamide, N-[(5aR,6aS,7S,10aS)-9-(aminocarbonyl)-7-(dimethylamino)-4-fluoro-5,5a,6,6a,7,10,10a,12-octahydro-1,8,10a,11-tetrahydroxy-10,12-dioxo-2-naphthacenyl] MOLECULAR FORMULA C27H31FN4O8 MOLECULAR WEIGHT 558.6 SPONSOR Tetraphase Pharmaceuticals, Inc. CODE DESIGNATION TP-434 CAS REGISTRY NUMBER 1207283-85-9 WHO NUMBER 9702 Eravacycline (TP-434) is a synthetic fluorocycline antibiotic in development by Tetraphase Pharmaceuticals. It is closely related to the glycylglycine …
Polymers from biomass: one pot two-step synthesis of furilydenepropanenitrile derivatives with MIL-100(Fe) catalyst
It’s only fair to share… Polymers from biomass: one pot two-step synthesis of furilydenepropanenitrile derivatives with MIL-100(Fe) catalyst Catal. Sci. Technol., 2017, 7,3008-3016 DOI: 10.1039/C7CY00463J, Paper Anastasia Rapeyko, Karen S. Arias, Maria J. Climent, Avelino Corma, Sara Iborra Monomers from biomass have been prepared from HMF and methylene active compounds through a one pot process using …
Recent progress on fluorination in aqueous media
It’s only fair to share… Recent progress on fluorination in aqueous media Green Chem., 2017, Advance Article DOI: 10.1039/C7GC01566F, Tutorial Review Lian Yang, Tao Dong, Hrishikesh M. Revankar, Cheng-Pan Zhang Advances of fluorination in aqueous media during the last few decades are summarized in this review Recent progress on fluorination in aqueous media Lian …
Rosiptor acetate
It’s only fair to share… Rosiptor acetate CAS: 782487-29-0 (acetate) 782487-28-9 (free base) Chemical Formula: C22H39NO4 Molecular Weight: 381.557 AQX-1125; AQX 1125; AQX1125; AQX-1125 acetate; Rosiptor acetate PHASE 3 …..a SH2-containing inositol 5-phosphatase 1 (SHIP1) modulator for treating cancer, inflammatory disorders and immune disorders. (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(Aminomethyl)-7a-methyl-1- methyleneoctahydro -1H – inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol, acetate IUPAC/Chemical Name: (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol acetate Originator Aquinox Pharmaceuticals Class Anti-inflammatories; …
N‒(4’‒methoxyCinnamyl)aniline ( NMR IS EASY)
It’s only fair to share… N‒(4’‒methoxyCinnamyl)aniline N‒(4’‒Methoxycinnamyl)aniline (3s): Yellow brown solid (203 mg, 85% yield), mp. 75 oC, 1H NMR (CDCl3, 600 MHz): δ 3.86 (s, 3H), 3.94 (d, 2H, J = 11.5 Hz), 6.20‒ 6.29 (m, 1H), 6.60 (d, 1H, J = 15.9 Hz), 6.74 (d, 2H, J = 8.28 Hz), 6.80 (t, …
N-(1-adamantile)-4-chlorobenzamide ( NMR IS EASY)
It’s only fair to share… N-(1-adamantile)-4-chlorobenzamide EVEN MOM CAN TEACH U NMR N-(1-Adamantile)-4-chlorobenzamide (7a): White solid (231 mg, 80%), 1H NMR(600 MHz, CDCl3): 7.71 (d, J = 8.22 Hz, 2H), 7.41 (d, J = 8.22 Hz, 2H), 6.36 (brs, 1H), 4.24 (d, J = 7.02 Hz, 1H), 2.04 (s, 2H), 1.90 (brs, 6H), 1.84 …
CuI nanoparticles as recyclable heterogeneous catalysts for C-N bond formation reactions
It’s only fair to share… CuI nanoparticles as recyclable heterogeneous catalysts for C-N bond formation reactions Catal. Sci. Technol., 2017, 7,2857-2864 DOI: 10.1039/C7CY00832E, Paper Manoranjan Kumar, Vinod Bhatt, Onkar S. Nayal, Sushila Sharma, Vishal Kumar, Maheshwar S. Thakur, Neeraj Kumar, Rajaram Bal, Bikram Singh, Upendra Sharma Herein, copper iodide nanoparticles (NPs) are reported for the …
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry
It’s only fair to share… Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry Med. Chem. Commun., 2017, 8,1378-1392 DOI: 10.1039/C7MD00109F, Review Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Alice Coletti, Francesco Antonio Greco, Daniela Dolciami, Emidio Camaioni, Roccaldo Sardella, Maria Teresa Pallotta, Claudia Volpi, Ciriana Orabona, Ursula Grohmann, …
3-Phenylpropionic acid
It’s only fair to share… 3-Phenylpropionic acid (2z) 1 1) Jiang, X.; Zhang, J.; Ma. S. J. Am. Chem. Soc. 2016, 138, 8344 Yield: 94% (142 mg), white solid. Melting point: 47-49 °C (lit.18 49 °C) (18) Helavi, V. B.; Solabannavar, S. B.; Desai, U. V.; Mane, R. B. J. Chem. Research 2003, …