It’s only fair to share… IH NMR ABOVE 13C NMR BELOW Benzo[d]oxazol-2(3H)-one (2a) pale yellow crystals; mp 140.5–141.5 °C (lit.(6a) 134–136 °C); 1H NMR (300 MHz, CDCl3) δ 9.90 (s, 1H), 7.26–7.09 (m, 4H); 13C NMR (75 MHz, CDCl3) δ 156.3, 143.9, 129.4, 124.2, 122.8, 110.3, 110.2. NMR PREDICT 1H NMR PREDICT 13C NMR PREDICT ////////// …
LOXO 195
It’s only fair to share… LOXO-195 CAS: 2097002-61-2 Chemical Formula: C20H21FN6O Molecular Weight: 380.4274 2097002-59-8 (RS-isomer) 1350884-56-8 (R racemic) Synonym: LOXO-195; LOXO 195; LOXO195. IUPAC: (13E,14E,22R,6R)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one 10H-5,7-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-10-one, 17-fluoro-1,2,3,11,12,13,14,18b-octahydro-12-methyl-, (12R,18bR)- SMILES Code: FC1=CN=C(CC[C@@H](C)NC(C2=C3N(C=CC4=N3)N=C2)=O)C([C@@H]5N4CCC5)=C1 LOXO-195 is a potent and selective TRK inhibitor capable of addressing potential mechanisms of acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or …
NaBH4, twin screw technology (i.e., granulator, melt extruder, etc.) to yield the desired product in a continuous manner
It’s only fair to share… In this work the application of green chemistry principles such as process intensification and the replacement of reagents and solvents to more benign alternatives were coupled with the advantages of continuous manufacturing. The reduction of lipophilic aromatic aldehydes using an aqueous alkaline solution of NaBH4 was achieved by means of …
Ascaridole
It’s only fair to share… Scheme 2. Photo-Oxidation of α-terpinene 1 to Ascaridole 2 and the Common Byproduct p-Cymene 3 Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory Darren S. Lee† , Zacharias Amara†, Charlotte A. Clark†, Zeyuan Xu‡, Bruce Kakimpa‡, Herve P. Morvan‡, Stephen J. Pickering‡, Martyn Poliakoff*†, and Michael W. George*†§ †School of Chemistry, ‡Department of Mechanical, Materials and Manufacturing Engineering, University of …
Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions
It’s only fair to share… Atom- and step-economical nucleophilic arylation of azaaromatics via electrochemical oxidative cross C-C coupling reactions Green Chem., 2017, 19,2931-2935 DOI: 10.1039/C7GC00789B, Communication O. N. Chupakhin, A. V. Shchepochkin, V. N. Charushin A simple and efficient electrochemical method for the synthesis of asymmetrical bi(het)aryls through direct functionalization of the C(sp2)-H bond in …
Increasing global access to the high-volume HIV drug nevirapine through process intensification
It’s only fair to share… Increasing global access to the high-volume HIV drug nevirapine through process intensification Green Chem., 2017, 19,2986-2991 DOI: 10.1039/C7GC00937B, Paper Jenson Verghese, Caleb J. Kong, Daniel Rivalti, Eric C. Yu, Rudy Krack, Jesus Alcazar, Julie B. Manley, D. Tyler McQuade, Saeed Ahmad, Katherine Belecki, B. Frank Gupton Fundamental elements of process …
Cp2TiCl: An Ideal Reagent for Green Chemistry?
It’s only fair to share… The development of Green Chemistry inevitably involves the development of green reagents. In this review, we highlight that Cp2TiCl is a reagent widely used in radical and organometallic chemistry, which shows, if not all, at least some of the 12 principles summarized for Green Chemistry, such as waste …
One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone
It’s only fair to share… One-pot synthesis of 2-hydroxymethyl-5-methylpyrazine from renewable 1,3-dihydroxyacetone Green Chem., 2017, Advance Article DOI: 10.1039/C7GC00578D, Communication Lei Song, Mingyuan Zheng, Jifeng Pang, Joby Sebastian, Wentao Wang, Minjie Qu, Jian Zhao, Xinhong Wang, Tao Zhang An efficient and environmentally benign method for the synthesis of 2-hydroxymethyl-5-methylpyrazine (HMMP) from biomass derived 1,3-dihydroxyacetone …
Imigliptin dihydrochloride, Xuanzhu Pharma Co Ltd, NEW PATENT, WO 2017107945
It’s only fair to share… Imigliptin dihydrochloride, Xuanzhu Pharma Co Ltd, NEW PATENT, WO 2017107945 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017107945&redirectedID=true Applicants: XUANZHU PHARMA CO.,LTD. [CN/CN]; 2518, Tianchen Street, National High-tech Development Zone Jinan, Shandong 250101 (CN) Inventors: SHU, Chutian; (CN). WANG, Zhenhua; (CN) The present invention relates to a crystalline form of benzoate of a dipeptidyl peptidase-IV inhibitor, a method for preparing …
Lisdexamphetamine
It’s only fair to share… Lisdexamfetamine Molecular FormulaC15H25N3O Average mass263.379 Da 608137-32-2 [RN] Elvanse [Trade name] Hexanamide, 2,6-diamino-N-[(1S)-1-methyl-2-phenylethyl]-, (2S)- Lisdexamfetamine L-lysine-d-amphetamine (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanimidic acid H645GUL8KJ L-lysine-(+)-amphetamine NRP104|Vyvanse® UNII:H645GUL8KJ UNII-H645GUL8KJ Vyvanse® CAS 608137-33-3 (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide dimethanesulfonate https://www.google.com/patents/WO2005032474A2 Applicants: NEW RIVER PHARMACEUTICALS INC. [US/US]; The Governor Tyler, 1881 Grove Avenue, Radford, VA 24141 (US) (For All Designated States Except US). …