It’s only fair to share… Example 4 – Preparation Of Compound 4 ((3R,4S)-4-(3-(methylsulfonyl)phenyl)-l-propylpiperidin-3-ol) Preparation of dS,6S)-6-(3-(methylsulfonvnphenyl)-3-propyl-7-oxa-3-azabicyclo [4.1.Olheptane (1S,6S)-6-(3-(methylsulfonyl)p enyl) -3-propyl-7-oxa-3-azabicyclo [4.1.0]heptane Into a 4L reactor was added at room temperature Compound 8 (229g, 820mmol, leq) and 2N sulfuric acid (1147mL, 112g sulfuric acid, 1.147mol, 1.4eq). The reaction light yellow mixture was stirred and sodium bromate …
(l-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine)
It’s only fair to share… Example 6 – Preparation Of Compound (l-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine) 1-(2-methylpentyl)-4-(3- (methylsulfonyl)phenyl)piperidine Into a 1L autoclave was added KI (28.4g, 171mmol leq) and potassium carbonate (47.4g, 343mmol, 2eq). 4-(3-(methylsulfonyl)phenyl)piperidine (41g, 171mmol, leq) was dissolved in acetonitrile (420mL) and the mixture was added into the autoclave followed by l-chloro-2-methylpentane (25.8mL, 188mmol, l .leq). The …
New Website goflow.at online! from C. Oliver Kappe, University of Graz
It’s only fair to share… New Website goflow.at online! C. Oliver Kappe Professor at University of Graz Institute of Chemistry Univ.-Prof. Mag. Dr.rer.nat. +43 316 380-5352 +43 (0) 316 380 – 9840 Oliver.kappe (at) uni-graz.at Research in the Kappe lab focuses on flow chemistry, microreactor technology, process intensification and the continuous generation of active pharmaceutical ingredients …
Darifenacin Hydrobromide, 臭化水素酸ダリフェナシン
It’s only fair to share… Darifenacin 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide Darifenacin; Emselex; Enablex; CAS 133099-04-4; UNII-APG9819VLM; US 2004-12-22 APPROVED EU 2004-10-22 APPROVED Molecular Formula: C28H30N2O2 Molecular Weight: 426.56 g/mol Title: Darifenacin CAS Registry Number: 133099-04-4 CAS Name: (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a,a-diphenyl-3-pyrrolidineacetamide Additional Names: 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine; (S)-2-[1-[2-(2,3,-dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide Manufacturers’ Codes: UK-88525 Molecular Formula: C28H30N2O2 Molecular Weight: 426.55 Percent Composition: C 78.84%, H 7.09%, N 6.57%, O …
MK 0633, SETILEUTON
It’s only fair to share… MK 0633, SETILEUTON (-)-enantiomer 910656-27-8 CAS free form MW 463.3817, C22 H17 F4 N3 O4 FREE FORM Tosylate cas 1137737-87-1 2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]- 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one WO2006099735A1 Inventors Thiadiazole substituted coumarin derivatives and their use as leukotriene biosynthesis inhibitor WO 2006099735 A1Marc Blouin, Erich L. Grimm, Yves Gareau, Marc Gagnon, Helene Juteau, Sebastien Laliberte, Bruce …
Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts
It’s only fair to share… Highly chemoselective reduction of nitroarenes over non-noble metal nickel-molybdenum oxide catalysts Green Chem., 2017, 19,809-815 DOI: 10.1039/C6GC03141B, Paper Haigen Huang, Xueguang Wang, Xu Li, Chenju Chen, Xiujing Zou, Weizhong Ding, Xionggang Lu A non-noble Ni-MoO3/CN@SBA-15 catalyst exhibits unprecedented catalytic activity and chemoselectivity for the reduction of nitroarenes to anilines in …
Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature
It’s only fair to share… Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03494B, Paper Zheng Fang, Wen-Li Hu, De-Yong Liu, Chu-Yi Yu, Xiang-Guo Hu A procedure for the synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions has been developed. Synthesis of tetrazines from gem-difluoroalkenes under …
Photobiocatalytic alcohol oxidation using LED light sources
It’s only fair to share… Photobiocatalytic alcohol oxidation using LED light sources Oxidative lactonization of meso-3-methyl-1,5-pentanediol to (S)-4-methyltetrahydro-2H-pyran-2-one using horse liver alcohol dehydrogenase (HLADH) and photocatalytic, aerobic regeneration of NAD+. Green Chem., 2017, 19,376-379 DOI: 10.1039/C6GC02008A, Communication Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. M. Rauch, S. …
Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation
It’s only fair to share… Fig. 3 Stereoselectivities of the new ApPDC-variants for the synthesis of (S)-PAC. The different variants were tested as wet cells, crude cell extracts, and purified enzymes. Reaction conditions: wet cells – 20 mM benzaldehyde; 200 mM pyruvate; 50 mM KPi-buffer (pH 6.5), 2.5 mM MgSO4; 0.1 mM ThDP; 20 …
New Patent, (S)-pregabalin, WO 2017019791, Teva
It’s only fair to share… Synthesis of (S)-pregabalin, Teva WO-2017019791 TEVA PHARMACEUTICALS INTERNATIONAL GMBH [CH/CH]; Schusselstrasse 12 8645 Jona (CH) (For All Designated States Except US). JANAGANI, Satyanarayana [US/US]; (US) (US only) Improved process for preparing (S)-pregabalin, useful for treating pain, seizures, convulsions and anxiety. Also claims novel intermediates of (S)-pregabalin and their preparation method. …