It’s only fair to share… Velagliflozin 2-[(4-cyclopropylphenyl)methyl]-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzonitrile Velagliflozin L-proline H2O Velagliflozin, sold under the brand name Senvelgo, is an antidiabetic medication used for the treatment of cats.[2][4][5] Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor.[6] It is taken by mouth.[2] Velagliflozin is the active ingredient of the first oral liquid medication approved by the Food and Drug Administration for the treatment of …
Tag «diabetes»
Cetagliptin
It’s only fair to share… Cetagliptin CAS No. FREE FORM : 2243737-33-7 C18H18F6N4O, 420.4 g/mol [ Cetagliptin Phosphate 2243737-33-7 ] 분자량 MW 518.35 화학식 MF C18H21F6N4O5P (3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one (3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one CHINA 2024, APPROVALS 2024, CGeneTec, DIABETES, RegisteredType 2 diabetes mellitus CHINA 2024 Cetagliptin (CGT-8012) is an orally bioavailable, dipeptidyl peptidase 4 enzyme (DPP-4) inhibitor (‘gliptin’) class drug. It was …
Cofrogliptin
It’s only fair to share… Cofrogliptin HSK 7653 (2R,3S,5R,6S)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-6-(trifluoromethyl)oxan-3-amine APPROVALS 2024, CHINA 2024, Haisco Pharmaceutical Group Co, Beichangping, DIABETES Cofrogliptin (developmental name HSK7653) is a long-acting DPP4 inhibitor dosed once every two weeks.[1][2][3][4] Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 …
Dorzagliatin
It’s only fair to share… Dorzagliatin Dorzagliatin(18)was developed by Hua Medicine as a treatment for diabetic kidney disease(DKD), type1diabetes mellitus(T1DM), and type2 diabetes mellitus (T2DM). CHINA 2022 Dorzagliatin is a glucokinase activator that is being developed to treat diabetes.[1] Unlike other diabetes drugs, it is intended to increase insulin sensitivity.[2] Dorzagliatin is under investigation in clinical trial NCT03173391 (Long-term …
Chiglitazar
It’s only fair to share… Chiglitazar CAS 743438-45-1 Ingredient UNII CAS InChI Key Chiglitazar sodium, (S)- YN12H6OCV6 2390374-10-2 RMVIEXHXRDCWBT-UCRKPPETSA-M Chiglitazar was developed by Chipscreen Biosciences and was approved in China for improving glycemic control in adultpatients with type2 diabetes in October2021. Chiglitazar (trade name Bilessglu) is a drug for the treatment of type 2 diabetes.[1] It is a peroxisome proliferator-activated …
Imeglimin hydrochloride
It’s only fair to share… Meglimin hydrochloride Twymeeg Formula C6H13N5. HCl CAS 775351-61-6 (HCl). , C6H14ClN5 191.66 CAS 775351-65-0, FREEFORM 155.20 Mol weight 191.6619 AntidiabeticAPPROVED PMDA JAPAN2021/6/23, イメグリミン塩酸塩 (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine DB12509 NCGC00378621-02 HY-14771 Q6003719 UNII-UU226QGU97 UU226QGU97 1,3,5-Triazine-2,4-diamine,1,6-dihydro-N,N,6-trimethyl-,(+)-(9CI) (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine Imeglimin [INN] Emd 387008 (R-imeglimin) HCl EMD-387008 Imeglimin is an experimental drug being developed as an oral anti-diabetic.[1][2] It is an oxidative phosphorylation blocker that …
DAPAGLIFLOZIN
It’s only fair to share… DAPAGLIFLOZIN, BMS-512148 ダパグリフロジン; (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, Cas 461432-26-8 Molecular Formula: C21H25ClO6 Molecular Weight: 408.87 Dapagliflozin propandiol monohydrate; 960404-48-2 Molecular Weight 502.98 Formula C21H25ClO6•C3H8O2•H2O Bristol-Myers Squibb (Originator) AstraZeneca TYPE 2 DIABETES,SGLT-2 Inhibitors launched 2012, as forxiga in EU, FDA 2014, JAPAN PMDA 2014 Dapagliflozin propanediol monohydrate was first approved by European Medicine Agency (EMA) on November 12, …
Dasiglucagon
It’s only fair to share… Dasiglucagon Treatment of Hypoglycemia in Type 1 and Type 2 Diabetes Patients Formula C152H222N38O50 CAS 1544300-84-6 Mol weight 3381.6137 FDA APPROVED, 2021/3/22, Zegalogue Zealand Pharma A/S UNIIAD4J2O47FQ HypoPal rescue pen SVG Image IUPAC Condensed H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Aib-Ala-Arg-Ala-Glu-Glu-Phe-Val-Lys-Trp-Leu-Glu-Ser-Thr-OH Sequence HSQGTFTSDYSKYLDXARAEEFVKWLEST HELM PEPTIDE1{H.S.Q.G.T.F.T.S.D.Y.S.K.Y.L.D.[Aib].A.R.A.E.E.F.V.K.W.L.E.S.T}$$$$ IUPAC L-histidyl-L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-alpha-methyl-alanyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-phenylalanyl-L-valyl-L-lysyl-L-tryptophyl-L-leucyl-L-alpha-glutamyl-L-seryl-L-threonine (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-2-methylpropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-carboxy-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid . [16-(2-methylalanine)(S>X),17-L-alanine(R>A),20-L-α-glutamyl(Q>E),21-L-αglutamyl(D>E),24-L-lysyl(Q>K),27-L-α-glutamyl(M>E),28-L-serine(N>S)]human glucagon L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L- …
Ciglitazone
It’s only fair to share… Ciglitazone U-63287, ADD-3878 Molecular FormulaC18H23NO3S Average mass333.445 Da 74772-77-3 [RN] (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione 2,4-Thiazolidinedione, 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]- 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.[1][2][3][4] Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were …
VILDAGLIPTIN
It’s only fair to share… VILDAGLIPTIN Molecular FormulaC17H25N3O2 Average mass303.399 Da (2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile (2S)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile 274901-16-5 [RN] 2-Pyrrolidinecarbonitrile, 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)- (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile Vildagliptin was approved by the European Medicines Agency (EMA) on Sep 26, 2007, and approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on Jan 20, 2010, following by China Food and Drug Administration (CFDA) …