Drug Approvals International – Page 107 – All about Drugs Live by Dr Anthony Melvin Crasto

FIRSOCOSTAT, ND 630, GS-0976, NDI-010976

FIRSOCOSTAT, ND 630, NDI 010976, ND-630, NDI-010976 CAS: 1434635-54-7, UNII: XE10NJQ95M PHASE 2, Non-alcoholic steatohepatitis, GILEAD 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-3(2H)-acetic acid 2-[l-[2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5- methyl-6-(l,3-oxazol-2-yl)-2,4-dioxo-lH,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]-2- methylpropanoic acid 2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid CAS 1434635-54-7 Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo- Molecular Formula: C28H31N3O8S Molecular Weight: 569.62604 g/mol Company Nimbus Therapeutics LLC Description Small molecule allosteric inhibitor of acetyl-coenzyme A carboxylase alpha (ACACA; ACC1) and acetyl-coenzyme A carboxylase beta (ACACB; ACC2) …

Lanadelumab, ラナデルマブ

(Heavy chain) EVQLLESGGG LVQPGGSLRL SCAASGFTFS HYIMMWVRQA PGKGLEWVSG IYSSGGITVY ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAYRR IGVPRRDEFD IWGQGTMVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP G (Light chain) DIQMTQSPST LSASVGDRVT ITCRASQSIS SWLAWYQQKP …

Sodium zirconium cyclosilicate, ナトリウムジルコニウムシクロケイ酸塩

Sodium zirconium cyclosilicate ZS-9, ZS 9, UZSi-9 CAS 242800-27-7, H2 O3 Si . x H2 O . 2/3 Na . 1/3 Zr, Sodium zirconium cyclosilicate; Silicic acid (H2SiO3), Sodium zirconium(4+) salt (3:2:1), hydrate USAN CAS 17141-74-1, H6 O9 Si3 . 2 Na . Zr, Silicic acid (H2SiO3), sodium zirconium(4+) salt (3:2:1), hydrate, Sodium zirconium silicate (Na2ZrSi3O9) hydrate ナトリウムジルコニウムシクロケイ酸塩 ZrH4O6. 3H4SiO4. 2H2O. 2Na, 561.6068, AS IN kegg Molecular Formula, H6-O9-Si3.2Na.Z, Molecular Weight, 371.5004 …

Glycopyrronium bromide, гликопиррония бромид , بروميد غليكوبيرونيوم , 格隆溴铵 , グリコピロニウム臭化物

Glycopyrronium bromide гликопиррония бромид [Russian] [INN] بروميد غليكوبيرونيوم [Arabic] [INN] 格隆溴铵 [Chinese] [INN] グリコピロニウム臭化物 Cas 596-51-0, 3-Hydroxy-1,1-dimethylpyrrolidinium bromide α-cyclopentylmandelate (6CI,7CI) Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide (9CI) Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, α-cyclopentylmandelate (8CI) 1,1-Dimethyl-3-hydroxypyrrolidinium bromide α-cyclopentylmandelate AHR-504 Asecryl Copyrrolate Gastrodyn Glycopyrrolate Glycopyrrolate bromide Glycopyrrone bromide Glycopyrronium bromide NSC 250836 NSC 251251 NSC 251252 NVA 237 Nodapton Robanul Robinul Seebri Tarodyl Tarodyn β-1-Methyl-3-pyrrolidyl-α-cyclopentylmandelate methobromide CAS FREE …

Stiripentol, スチリペントール

Stiripentol スチリペントール STIRIPENTOL; Diacomit; 49763-96-4; BCX 2600; Estiripentol; Stiripentolum CAS: 137767-55-6 49763-96-4 (E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol Molecular Formula: C14H18O3 Molecular Weight: 234.295 g/mol UNII R02XOT8V8I, Diacomit fda approval 2018/8/20 Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is approved for the treatment of Dravet syndrome, an epilepsy syndrome. It is unrelated to other anticonvulsants and belongs to the …

Sucroferric oxyhydroxide, 含糖酸化鉄, スクロオキシ水酸化鉄

Sucroferric oxyhydroxide Iron sucrose (USP); Ferric oxide, saccharated; Sucroferric oxyhydroxide; Venofer (TN) 含糖酸化鉄; スクロオキシ水酸化鉄 Molecular Formula: C12H29Fe5Na2O23 Molecular Weight: 866.546 g/mol CAS: 8047-67-4 CAS REGISTRY NUMBER 12134-57-5, 8047-67-4 disodium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate Iron sugar; Saccharated iron; Sucroferric oxyhydroxide; Saccharated iron oxide; Saccharated ferric oxide; Ferrivenin Ferric oxyhydroxide; Ferrihydrite; Iron oxyhydroxide; P-TOL; PA-21; PA21-1; Phosphate binder – Vifor Pharma; …

Vericiguat, ベルイシグアト

Vericiguat BAY 102; BAY-1021189; MK-1242 1350653-20-1 Chemical Formula: C19H16F2N8O2 Molecular Weight: 426.3878 Vericiguat; 1350653-20-1; UNII-LV66ADM269; Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate; BAY-1021189; LV66ADM269 Methyl (4,6-diamino-2-(5-fluoro-1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl(pyrimidin-5-yl)carbamate methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate Methyl{4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridi- n-3-yl]pyrimidin-5-yl}carbamate Originator Bayer HealthCare Pharmaceuticals Developer Bayer HealthCare Pharmaceuticals; Merck & Co Mechanism of Action Guanylate cyclase stimulants Phase III Chronic heart failure Phase I Coronary artery disease 28 May 2018 Phase II VITALITY HFpEF trial for …

Ferric Maltol, マルトール第二鉄

Ferric Maltol Iron, tris(3-hydroxy-2-methyl-4H-pyran-4-onato-O3,O4)- Molecular Formula: C18H15FeO9 Molecular Weight: 431.154 g/mol iron(3+);2-methyl-4-oxopyran-3-olate RN: 33725-54-1 UNII: MA10QYF1Z0 Feraccru Ferric maltol; UNII-MA10QYF1Z0; MA10QYF1Z0; Ferric maltol (INN); Ferric maltol [INN]; 33725-54-1 Shield Therapeutics, under license from Vitra Pharmaceuticals UPDATE Originator University of Cambridge; University of London Developer Shield Therapeutics Class Antianaemics; Ferric compounds; Pyrones; Small molecules Mechanism of Action Iron replacements Marketed Iron deficiency anaemia …

Daprodustat, ダプロデュスタット

Daprodustat, GSK1278863 ダプロデュスタット CAS 960539-70-2 GSK1278863; GSK 1278863; GSK-1278863; Daprodustat C19H27N3O6 Exact Mass: 393.18999 (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine N-[(l,3-dicyclohexyl-6-hydroxy-2,4-dioxo-l,2,3,4- tetrahydro-5-pyrimidinyl)carbonyl]glycine 2-(1,3-dicyclohexyl-2,4,6-triohexahydropyrimidine-5-carboxamide acetic acid Mechanism of Action: HIF-prolyl hydroxylase inhibitor Indication: anemia, diabetic wounds, and reduction of ischemic complications Development Stage: Phase II Developer:GlaxoSmithKline UNII:JVR38ZM64B ダプロデュスタット Daprodustat C19H27N3O6 : 393.43 [960539-70-2] Daprodustat , also known as GSK1278863, is a novel HIF-prolyl …

Dasotraline, ダソトラリン

(1R,4S)-4-(3,4-Dichlorphenyl)-1,2,3,4-tetrahydro-1-naphthalinamine 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1R,4S)- [ACD/Index Name] 4D28EY0L5T 675126-05-3 [RN] 9885 SEP-225289 UNII:4D28EY0L5T (1R,4S)-N-DESMETHYL SERTRALINE (1R,4S)-trans-norsertraline (1R,4S)-trans-norsertraline|SEP-225289 Dasotraline; 675126-05-3; UNII-4D28EY0L5T; (1R,4S)-trans-Norsertraline; Norsertraline, (1R,4S)-trans-; SEP-225289 ダソトラリン SEP-225289; SEP-289, DSP-225289 Dasotraline, SEP-225289, DSP-225289 1R,4S Transnorsertraline Generic Name:Dasotraline Synonym: SEP-225289 Chemical Name:(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine 4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1(R)-ylamine hydrochloride CAS Number:675126-05-3, Cas of THE DRUG SUBSTANCE hydrochloride is 675126-08-6 Indication:Attention deficit hyperactivity disorder (ADHD) Drug Company:Sunovion Pharmaceuticals. Inc. in phase …