It’s only fair to share… Sotorasib 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one AMG 510 AMG-510 AMG510 Formula C30H30F2N6O3 CAS 2296729-00-3 Mol weight 560.5944 FDA APPROVED, 2021/5/28 Lumakras Antineoplastic, Non-small cell lung cancer (KRAS G12C-mutated) ソトラシブ (JAN); 2296729-00-3 (racemate) 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one Sotorasib [INN] 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one Sotorasib (1M)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one C30H30F2N6O3 : 560.59 [2296729-00-3] Sotorasib is an inhibitor of the RAS GTPase family. The molecular formula is C30H30F2N6O3, and the …
Category «APPROVALS 2021»
Infigratinib phosphate
It’s only fair to share… Infigratinib phosphate FDA APPR Truseltiq 2021/5/28 インフィグラチニブリン酸塩; 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-[6-[4-(4-ethylpiperazin-1-yl)anilino]pyrimidin-4-yl]-1-methylurea;phosphoric acid BGJ 398 BGJ-398 BGJ398 NVP-BGJ398 WHO 10032 Product Ingredients INGREDIENT UNII CAS INCHI KEY Infigratinib acetate 03D0789NYP 1310746-17-8 XHCQHOGMMJKLRU-UHFFFAOYSA-N Infigratinib hydrochloride WY8VD4RV77 1310746-15-6 VBAIJSJSFCXDJB-UHFFFAOYSA-N Infigratinib mesylate E223Z0KWCC 1310746-12-3 BXJJFNXYWJLBOS-UHFFFAOYSA-N Infigratinib phosphate 58BH47BV6S 1310746-10-1 GUQNHCGYHLSITB-UHFFFAOYSA-N International/Other BrandsTruseltiq (BridgeBio Pharma, Inc.) Formula C26H31Cl2N7O3. H3PO4 …
Ibrexafungerp citrate
It’s only fair to share… Ibrexafungerp citrate アイブレキサフンジェルプクエン酸塩; Formula C44H67N5O4. C6H8O7 cas 1965291-08-0 free 1207753-03-4 Mol weight 922.1574 Brexafemme, fda approved 2021, 2021/6/1 Antifungal, Cell wall biosynthesis inhibitor, Treatment of invasive fungal infections due to Candida spp. or Aspergillus spp., vulvovaginal candidiasis SCY-078 citrate, MK-3118; SCY-078, WHO 10597 UNII-M4NU2SDX3E M4NU2SDX3E (1R,5S,6R,7R,10R,11R,14R,15S,20R,21R)-21-[(2R)-2-amino-2,3,3-trimethylbutoxy]-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-20-(5-pyridin-4-yl-1,2,4-triazol-1-yl)-17-oxapentacyclo[13.3.3.01,14.02,11.05,10]henicos-2-ene-6-carboxylic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Originator Merck & Co; SCYNEXIS Class Antifungals; Glycosides; …
Idecabtagene vicleucel
It’s only fair to share… Idecabtagene vicleucel CAS 2306267-75-2 STN: BLA 125736 An autologous T lymphocyte-enriched cell transduced ex vivo with an anti-BCMA CAR lentiviral vector encoding a chimeric antigen receptor CAR, comprising a CD8 hinge and TM domain, 4-1BB costimulatory domain and CD3ζ signaling domain, targeting human B cell maturation antigen for cancer immunotherapy (Celgene …
Loncastuximab tesirine
It’s only fair to share… Loncastuximab tesirine ZYNLONTA FDA APPROVED 2021/4/23 https://www.adcreview.com/wp-content/uploads/2019/06/15_ICML_Chiara-Tarantelli-ADCT_402_preclinical.pdf Formula C6544H10048N1718O2064S52 Exact mass 147387.9585 CAS 1879918-31-6 Efficacy Antineoplasitc, Anti-CD19 antibody Disease Diffuse large B-cell lymphoma not otherwise specified [DS:H02434] Comment Antibody-drug conjugate Treatment of hematological cancers ロンカスツキシマブテシリン; ADCT-402, ADCX 19 Immunoglobulin G1, anti-(human CD19 antigen) (human-Mus musculus monoclonal RB4v1.2 γ1-chain), disulfide with human-Mus …
ZyCoV-D
It’s only fair to share… ZyCoV-D CAS 2541524-47-2 DNA vaccine construct encoding a spike protein antigen of SARS-CoV-2 virus (Zydus-Cadila) https://zyduscadila.com/public/pdf/Covid%2019_Booklet_9th%20FEB_FINAL.pdf http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=51254&EncHid=&userName=ZyCoV-D bioRxiv (2021), 1-26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423510/ ZyCoV-D | (CTRI/2020/07/026352, 2020, CTRI/2020/07/026352, 2020; Myupchar, 2020) ZYDUS CADILA ZyCoV-D is a genetically engineered DNA plasmid based vaccine encoding for the membrane proteins of the virus. The clinical trials to study the immunogenicity, …
2-Deoxy-D-glucose
It’s only fair to share… 2-Deoxy-D-glucose Molecular FormulaC6H12O5 Average mass164.156 Da 2-Deoxy-D-glucose (4R,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol (4R,5S,6R)-6-(Hydroxyméthyl)tétrahydro-2H-pyran-2,4,5-triol 154-17-6 [RN] 2-Deoxy-D-arabino-hexopyranose 2-deoxy-D-glucopyranose 2-deoxyglucose 2-DG D-arabino-2-Desoxyhexose D-arabino-Hexopyranose, 2-deoxy- [ (4R,5S,6R)-6-(Hydroxymethyl)oxane-2,4,5-triol 2-deoxyglucopyranose 2-deoxymannopyranose 2-dGlc 61-58-5 [RN] 77252-38-1 [RN] D-arabino-2-Deoxyhexose glucitol, 2,5-anhydro- 2-Deoxy-D-arabino-hexose 2 DG 2-Deoxy-D-glucose 2-Deoxy-D-mannose 2-Deoxyglucose 2-Desoxy-D-glucose Ba 2758 D-Glucose, 2-deoxy- NSC 15193 2-Deoxy-D-glucose CAS Registry Number: 154-17-6 CAS Name: 2-Deoxy-D-arabino-hexose Additional Names: D-arabino-2-desoxyhexose; 2-deoxyglucose; 2-DG Manufacturers’ …
Pegylated Interferon alpha-2b, (PegIFN), Virafin
It’s only fair to share… DB00022 sequence CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMI QQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVR KYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE Chemical structure of peginterferon α-2a and α-2b. Abbreviations: PeG-IFN, peginterferon; IFN, interferon; Lys, lysine; His, histidine; Cys, cysteine; Ser, serine. Pegylated Interferon alpha-2b (PegIFN), Virafin Formula C860H1353N229O255S9 …
DEXMETHYLPHENIDATE
It’s only fair to share… DEXMETHYLPHENIDATE SynonymsDexmethylphenidate HCl, UNII1678OK0E08, CAS Number19262-68-1, WeightAverage: 269.77 Chemical FormulaC14H20ClNO2 methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate hydrochloride CAS Number 40431-64-9 as HCl: 19262-68-1 PubChem CID 154101 as HCl: 154100 IUPHAR/BPS 7554 DrugBank DB06701 as HCl: DBSALT001458 ChemSpider 135807 as HCl: 135806 UNII M32RH9MFGP as HCl: 1678OK0E08 Trade Name：Focalin® / Attenade®MOA：Norepinephrine-dopamine reuptake inhibitorIndication：Attention deficit hyperactivity disorder (ADHD)Status：ApprovedCompany：Novartis (Originator) , CelgeneSales：$365 Million (Y2015); $492 Million …
Serdexmethylphenidate
It’s only fair to share… Serdexmethylphenidate Molecular FormulaC25H30ClN3O8 Average mass535.974 Da CAS 1996626-30-2 L-Serine, N-[[1-[[[[(2R)-2-[(1R)-2-methoxy-2-oxo-1-phenylethyl]-1-piperidinyl]carbonyl]oxy]methyl]-3-pyridiniumyl]carbonyl]-, chloride (1:1) N-[(1-{[({(2R)-2-[(1R)-2-Methoxy-2-oxo-1-phenylethyl]-1-piperidinyl}carbonyl)oxy]methyl}-3-pyridiniumyl)carbonyl]-L-serine chloride Azstarys, FDA APPROVED, 3/2/2021, Products on NDA 212994, Type 1 – New Molecular Entity and Type 4 – New Combination Serdexmethylphenidate Chloride (SDX), SDX or KP145 https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212994s000lbl.pdf Molecular Formula C25H30ClN3O8 Synonyms UNII-FN54BT298Y KP415 Cl Serdexmethylphenidate chloride FN54BT298Y …