Category «Preclinical»

Novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8),

It’s only fair to share… CAS 1620779-53-4 MF C22H20N4O2, MW 372.4 (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide 1H-1,2,3-Triazole-1-acetamide, 5-(2-cyclopropylethynyl)-N-hydroxy-4-phenyl-α-(phenylmethyl)-, (αS)- Applicants: TRUSTEES OF BOSTON UNIVERSITY DANA-FARBER CANCER INSTITUTE, INC. Inventors: Aaron Beaty BEELER John A. PORCO, JR. Oscar J. INGHAM James E. BRADNER As histone proteins bind DNA prior to transcription, their biochemical action plays a critical role in the regulation …

AZD 2716

It’s only fair to share… AZD2716 CAS 1845753-81-2 MF C24 H23 N O3,   MW 373.44 [1,1′-Biphenyl]-3-propanoic acid, 2′-(aminocarbonyl)-α-methyl-5′-(phenylmethyl)-, (αR)- Antiplaque candidate drug AstraZeneca INNOVATOR (R)-7(AZD2716) a novel, potent secreted phospholipase A2 (sPLA2) inhibitor with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. Based on accumulated profiling data, (R)-7 was selected …