It’s only fair to share… 4-(2-Fluoro-3chloro-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]-2-fluorophenoxy]-7-methoxy- N-(4-(6-Aminocarbonyl-7-methoxyquinolin-4-yl)oxy-2-chloro-3-fluorophenyl)-N’-cyclopropylurea cas 2304405-29-4 C21 H18 Cl F N4 O4 444.84 CN109134365 discloses an active compound or medicinal salt with multi-target effects of VEGFR1~3, fibroblast growth factor receptor 1~3, RET, Kit and PDGFR, and its chemical structure formula is as follows: Formula I: Chemical name: 4-(2-Fluoro-3chloro-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinoline carboxamide, the drug name is …
Category «Uncategorized»
Difelikefalin acetate
It’s only fair to share… Difelikefalin acetate ジフェリケファリン酢酸塩 CAS 1024829-44-4 Formula C36H53N7O6. (C2H4O2)x D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4- carboxylic acid)]-OH FDA APPROVED, 2021/8/23, FORSUVA Analgesic, Antipruritic, Opioid receptor agonist Treatment of moderate-to-severe pruritus associated with chronic kidney disease in adults undergoing hemodialysis Difelikefalin, CR-845; MR-13A-9; MR-13A9 4-amino-1- (D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl) piperidine-4-carboxylic acid C36H53N7O6, 679.40573 ORIGINATOR Ferring Pharmaceuticals DEVELOPER Cara Therapeutics CLASS Analgesic …
Pepinemab, VX 15
It’s only fair to share… (Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGYSFS DYYMHWVRQA PGQGLEWMGQ INPTTGGASY NQKFKGKATI TVDKSTSTAY MELSSLRSED TAVYYCARYY YGRHFDVWGQ GTTVTVSSAS TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY GPPCPPCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGK (Light chain) DIVMTQSPDS …
AVASOPASEM MANGANESE
It’s only fair to share… AVASOPASEM Average: 518.83 Monoisotopic: 517.134397 Chemical FormulaC21H35Cl3MnN5 manganese(2+);(4S,9S,14S,19S)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride Manganese, dichloro((4aS,13aS,17aS,21aS)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-7,11-nitrilo-7H-dibenzo(b,H)-5,13,18,21-tetraazacycloheptadecine-kappaN5,kappaN13,kappaN18,kappaN21,kappaN22)-, (pb-7-11-2344’3′)- CAS 435327-40-5 A superoxide dismutase mimetic. GC 4419 M-40419 SC-72325A For the Reduction of The Severity and Incidence of Radiation and Chemotherapy-Induced Oral Mucositis Avasopasem manganese, also known as GC4419, is a highly-selective small molecule mimetic of superoxide dismutase (SOD) …
Belzutifan
It’s only fair to share… Belzutifan CAS 1672668-24-4 383.34 g·mol−1 C17H12F3NO4S 3-[[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl]oxy]-5-fluorobenzonitrile MK-6482, PT-2977, UNII-7K28NB895L, 7K28NB895L 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile 3-{[(1s,2s,3r)-2,3-Difluoro-1-Hydroxy-7-(Methylsulfonyl)-2,3-Dihydro-1h-Inden-4-Yl]oxy}-5-Fluorobenzonitrile GTPL11251, PT 2977 [WHO-DD], BDBM373040 FDA APPROVED 8/13/2021, Welireg To treat von Hippel-Lindau disease under certain conditions EMA Drug Information Disease/Condition Treatment of von Hippel-Lindau disease Active Substance 3-(((1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile Status of Orphan Designation Positive Decision Date 2020-08-21 FDA approves belzutifan for cancers associated with von Hippel-Lindau disease On …
Naftopidil
It’s only fair to share… Naftopidil 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol C24H28N2O3, 392.49 CAS 57149-07-2 KT-611, Flivas, Avishot 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol Naftopidil (Flivas), BM-15275 Naftopidil CAS Registry Number: 57149-07-2 CAS Name: 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Additional Names: RS-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol; 1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine Manufacturers’ Codes: KT-611 Trademarks: Avishot (Kanebo); Flivas (Asahi) Molecular Formula: C24H28N2O3 Molecular Weight: 392.49 Percent Composition: C 73.44%, H 7.19%, N 7.14%, O 12.23% Literature References: a1-Adrenergic blocker and serotonin (5HT1A) receptor agonist. Prepn: E. C. Witte et al., DE 2408804; eidem, US 3997666 (1975, 1976 …
Pralnacasan
It’s only fair to share… Pralnacasan VX 740 cas 192755-52-5 (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide N-[(4S,7S)-4-{[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]carbamoyl}-6,10-dioxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-yl]isoquinoline-1-carboxamide (1S,9S)-N-((2R,3S)-2-Ethoxy-5-oxotetrahydrofuran-3-yl)-9-((isoquinolin-1-ylcarbonyl)amino)-6,10-dioxooctahydro-6-H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxamide, N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)amino)-6,10-dioxo-, (1S,9S)- HMR 3480 HMR3480 HMR3480/VX-740 Pralnacasan UNII-N986NI319S VX 470 VX-740 C26H29N5O7, 523.543 NSAID, ICE inhibitor & metastasis inhibitor. пралнаказан [Russian] [INN] برالناكاسان [Arabic] [INN] 普那卡生 [Chinese] [INN] Pralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE). Pralnacasan is …
VX 148
It’s only fair to share… VX 148 297730-05-3 Name: VX-148 CAS#: 297730-05-3 Chemical Formula: C23H25N5O4 Exact Mass: 435.19065 Molecular Weight: 435.48 Elemental Analysis: C, 63.44; H, 5.79; N, 16.08; O, 14.70 Molecular Weight 435.48 Formula C23H25N5O4 CAS No. 297730-05-3 (VX 148); Chemical Name Carbamic acid, N-[(1S)-1-[3-[[[(4-cyano-3-methoxyphenyl)amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester MOA：Inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitorIndication：PsoriasisStatus：Phase Ⅱ (Discontinued)Company：Vertex (Originator) …
VX- ? (3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide)
It’s only fair to share… VX- ? CAS 2446817-72-5 HYDRATE 2446818-26-2 Acetic acid, 1-methylethyl ester 2446818-27-3 C21 H20 F N3 O3, 381.4 1H-Indole-3-propanamide, 2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]- 3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD). PATENT WO/2021/158666 SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME Compound I is disclosed as Compound 87 …
PROPOFOL
It’s only fair to share… Propofol CAS Registry Number: 2078-54-8 CAS Name: 2,6-Bis(1-methylethyl)phenol Additional Names: 2,6-diisopropylphenol; disoprofol Manufacturers’ Codes: ICI-35868 Trademarks: Ansiven (Abbott); Diprivan (AstraZeneca); Disoprivan (AstraZeneca); Rapinovet (Schering-Plough Vet.) Molecular Formula: C12H18O Molecular Weight: 178.27 Percent Composition: C 80.85%, H 10.18%, O 8.97% Literature References: Prepn: A. J. Kolka et al., J. Org. Chem. 21, 712 (1956); 22, 642 (1957); G. G. Ecke, A. J. Kolka, US 2831898 (1958 to Ethyl Corp.); …