It’s only fair to share… Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban Makoto Michida*† , Hideaki Ishikawa†, Takeshi Kaneda†, Shinya Tatekabe‡, and Yoshitaka Nakamura§ †Process Technology Research Laboratories (PTRL), Daiichi Sankyo Co., Ltd., 1-12-1 Shinomiya, Hiratsuka-shi, Kanagawa 254-0014, Japan ‡Plant Management Department, Daiichi Sankyo Chemical Pharma Co., Ltd., 477 Takada, Odawara-shi, Kanagawa 250-0216, Japan §Global Supply Chain – Technology Function, Daiichi Sankyo, Inc., 211 Mt. Airy …
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Viloxazine, ヴィロキサジン;
It’s only fair to share… Viloxazine Molecular FormulaC13H19NO3 Average mass237.295 Da 2-[(2-Ethoxyphenoxy)methyl]morpholine 256-281-7 [EINECS] 3489 46817-91-8 free [RN], Hcl 35604-67-2 5I5Y2789ZF Emovit [Wiki] Morpholine, 2-((2-ethoxyphenoxy)methyl)- Morpholine, 2-[(2-ethoxyphenoxy)methyl]- UNII:5I5Y2789ZF Viloxazine hydrochloride OQW30I1332 35604-67-2 Polymorph FORM A , B US226136693, US2011032013 Viloxazine (trade names Vivalan, Emovit, Vivarint and Vicilan) is a morpholine derivative and is a selective norepinephrine reuptake inhibitor (NRI). It was used as an antidepressant in some European countries, and produced …
Macimorelin acetate
It’s only fair to share… Macimorelin Molecular FormulaC26H30N6O3 Average mass474.555 Da CAS 381231-18-1 Chemical Formula: C26H30N6O3 Exact Mass: 474.23794 Molecular Weight: 474.55480 Elemental Analysis: C, 65.80; H, 6.37; N, 17.71; O, 10.11 2-Methylalanyl-N-[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]-D-tryptophanamide 381231-18-1 [RN] 8680B21W73 9073 D-Tryptophanamide, 2-methylalanyl-N-[(1R)-1-(formylamino)-2-(1H-indol-3-yl)ethyl]- CAS 945212-59-9 (Macimorelin acetate) (2R)-2-(2-amino-2-methylpropanamido)-3-(1H-indol-3-yl)-N-[(1R)-2-(1H-indol-3-yl)-1-formamidoethyl]propanamide; acetic acid AEZS-130 ARD-07 D-87875 EP-01572 EP-1572 JMV-1843 USAN (ab-26) MACIMORELIN ACETATE AQZ1003RMG …
Cannabidiol, カンナビジオール;
It’s only fair to share… Cannabidiol カンナビジオール; Formula C21H30O2 CAS 13956-29-1 Mol weight 314.4617 FDA APPROVED, 2018/6/25, Epidiolex (Greenwich Biosciences) Efficacy Anticonvulsant, Antiepileptic, Cannabinoid receptor agonist Comment Treatment of seizures 1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-3-cyclohexen-1-yl]-5-pentyl- 2-[(1R,6R)-6-Isopropenyl-3-methyl-3-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol GWP42003-P UNII:19GBJ60SN5 GW Research Ltd APH-1501 BRCX-014 BTX-1204 BTX-1503 CBD GW-42003 GWP-42003 GWP-42003-P PLT-101 PTL-101 ZYN-002 Cannabidiol CAS Registry Number: 13956-29-1 CAS Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol …
TIABENDAZOLE, тиабендазол , تياباندازول , 噻苯达唑 , チアベンダゾール;
It’s only fair to share… TIABENDAZOLE CAS: 148-79-8 Molecular FormulaC10H7N3S Average mass201.248 Da тиабендазол [Russian] [INN] تياباندازول [Arabic] [INN] 噻苯达唑 [Chinese] [INN] チアベンダゾール; 1436 148-79-8 [RN] 1H-Benzimidazole, 2-(4-thiazolyl)- 2-(1,3-Thiazol-4-yl)-1H-benzimidazole 2-(4-Thiazoly)benzimidazole 205-725-8 [EINECS] 28558-32-9 [RN] 90507-06-5 [RN] Arbotect [Trade name] Benzimidazole, 2-(4-thiazolyl)- Mintezol [Trade name] N1Q45E87DT MK 360 / MK-360 / NSC-525040 / NSC-90507 Tiabendazole (INN, BAN), thiabendazole (AAN, USAN), TBZ (and the trade names Mintezol, Tresaderm, and Arbotect) is a preservative[1] 2-Substituted benzimidazole first introduced in 1962. It is active …
Elapegademase, エラペグアデマーゼ (遺伝子組換え)
It’s only fair to share… AQTPAFNKPK VELHVHLDGA IKPETILYYG RKRGIALPAD TPEELQNIIG MDKPLSLPEF LAKFDYYMPA IAGSREAVKR IAYEFVEMKA KDGVVYVEVR YSPHLLANSK VEPIPWNQAE GDLTPDEVVS LVNQGLQEGE RDFGVKVRSI LCCMRHQPSW SSEVVELCKK YREQTVVAID LAGDETIEGS SLFPGHVKAY AEAVKSGVHR TVHAGEVGSA NVVKEAVDTL KTERLGHGYH TLEDTTLYNR LRQENMHFEV CPWSSYLTGA WKPDTEHPVV RFKNDQVNYS LNTDDPLIFK STLDTDYQMT KNEMGFTEEE FKRLNINAAK SSFLPEDEKK ELLDLLYKAY GMPSPA >>Elapegademase<<< AQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEF LAKFDYYMPAIAGSREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAE GDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAID LAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYH TLEDTTLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFK STLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPA Elapegademase, エラペグアデマーゼ (遺伝子組換え) EZN-2279 Protein chemical formula C1797H2795N477O544S12 …
Fezolinetant, фезолинетант , فيزولينيتانت , 非唑奈坦 ,
It’s only fair to share… Fezolinetant ESN-364 Molecular FormulaC16H15FN6OS Average mass358.393 Da Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)- UNII:83VNE45KXX фезолинетант [Russian] [INN] فيزولينيتانت [Arabic] [INN] 非唑奈坦 [Chinese] [INN] (4-Fluorophenyl)[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone 10205 1629229-37-3 [RN] 83VNE45KXX Originator Euroscreen Developer Ogeda Class Pyrazines; Small molecules; Triazoles Mechanism of Action Gonadal steroid hormone modulators; Neurokinin 3 receptor antagonists Phase II Hot flashes; Polycystic ovary syndrome; Uterine leiomyoma Preclinical Weight gain DiscontinuedBenign prostatic hyperplasia; Endometriosis 14 Sep 2018 Ogeda completes …
Calaspargase pegol, カラスパルガーゼペゴル
It’s only fair to share… LPNITILATG GTIAGGGDSA TKSNYTAGKV GVENLVNAVP QLKDIANVKG EQVVNIGSQD MNDDVWLTLA KKINTDCDKT DGFVITHGTD TMEETAYFLD LTVKCDKPVV MVGAMRPSTS MSADGPFNLY NAVVTAADKA SANRGVLVVM NDTVLDGRDV TKTNTTDVAT FKSVNYGPLG YIHNGKIDYQ RTPARKHTSD TPFDVSKLNE LPKVGIVYNY ANASDLPAKA LVDAGYDGIV SAGVGNGNLY KTVFDTLATA AKNGTAVVRS SRVPTGATTQ DAEVDDAKYG FVASGTLNPQ KARVLLQLAL TQTKDPQQIQ QIFNQY (tetramer; disulfide bridge 77-105, 77′-105′, 77”-105”, 77”’-105”’) Calaspargase pegol Molecular Formula, C1516-H2423-N415-O492-S8 (peptide monomer), Molecular Weight, 10261.2163 …
IMETELSTAT
It’s only fair to share… IMETELSTAT CAS 868169-64-6, N163L Molecular Formula, C148-H211-N68-O53-P13-S13, Molecular Weight, 4610.2379, Nucleic Acid Sequence Sequence Length: 135 a 1 c 4 g 3 tmodified DNA d(3′-amino-3′-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A) 5′-[O-[2-hydroxy-3-[(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate] PHASE 3, GERON, Myelodysplasia IMETELSTAT SODIUM CAS 1007380-31-5, GRN163L, GRN 163L Sodium Salt Molecular Formula: C148H198N68Na13O53P13S13 Molecular Weight: 4895.941 g/mol 5′-(O-(2-hydroxy-3-((1-oxohexadecyl)amino)propyl)phosphorothioate)-d(3′-amino-3′-deoxy-p-thio)(t-a-g-g-g-t-t-a-g-a-c-a-a), sodium salt (13) …
Gemigliptin tartrate sesquihydrate, ゲミグリプチン
It’s only fair to share… Gemigliptin tartrate sesquihydrate; ゲミグリプチン Molecular Weight 666.47 Formula C18H19F8N5O2 • C4H6O6 • 1.5H2O 911637-19-9 (Gemigliptin); 1375415-82-9 (Gemigliptin L-tartrate Sesquihydrate) (3S)-3-amino-4-(5,5-difluoro-2-oxopiperidino)-1-[2,4-di(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-7-yl]butan-1-one L-tartrate, sesquihydrate 1-{(2S)-2-Amino-4-[2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl}-5,5-difluoro-2-piperidinone[ACD/IUPAC Name] 2-Piperidinone, 1-[(2S)-2-amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro- 5DHU18M5D6 911637-19-9 [RN] FREE FORM 9291 Gemigliptin gemigliptin tartarate gemigliptin(lc15-0444) LC15-0444 MFCD19443742 UNII:5DHU18M5D6 Gemiglo®; LC-150444; Zemiglo Gemigliptin L-tartrate sesquihydrate was approved by Korean food and Drug …