It’s only fair to share… 1,2-Bis(3-methoxyphenyl)benzene (5) 1H NMR (500 MHz, DMSO-d6): δ 3.59 (s, 6H), 6.65 (dd, J = 2.5, 1.5 Hz, 2H), 6.70 (ddd, J = 7.5, 1.5, 1.0 Hz, 2H), 6.78 (ddd, J= 8.0, 2.5, 1.0 Hz, 2H), 7.16 (t, J = 8.0 Hz, 2H), 7.40–7.46 (m, 4H). 13C NMR (126 MHz, DMSO-d6): δ 54.8, 112.4, 115.0, 121.7, 127.7, …
Category «Uncategorized»
Development of a General Protocol To Prepare 2H-1,3-Benzoxazine Derivatives
It’s only fair to share… 2H-1,3-Benzoxazine natural products and related bioactive molecules. 4-(2-Bromo-5-chlorobenzyl)-7-chloro-2-phenyl-2H-benzo[e][1,3]oxazine 2 as a light-yellow solid (82% yield). 1H NMR (500 MHz, CDCl3): δ (ppm) 7.55–7.52 (m, 3H), 7.42–7.34 (m, 3H), 7.30 (d, 1H, J = 3.5 Hz,) 7.29 (s, 1H), 7.12 (dd, 1H, J = 8.5 Hz, 2.5 Hz), 6.95–6.91 (m, 2H), 6.57 (1H, s), 4.16 (ABq, …
Xanomeline (LY-246,708; Lumeron, Memcor) ксаномелин , كسانوميلين , 诺美林 ,
It’s only fair to share… Xanomeline (LY-246,708; Lumeron, Memcor) CAS 131986-45-3 Molecular FormulaC14H23N3OS Average mass281.417 Da ксаномелин , كسانوميلين , 诺美林 , Hexyloxy-TZTP 5-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1-méthyl-1,2,3,6-tétrahydropyridine Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. in vitro: Xanomeline had high affinity for muscarinic receptors in brain homogenates, but had substantially less or no affinity for a number …
Diethyl Chlorophosphate
It’s only fair to share… Diethyl Chlorophosphate (CAS no 814–49–3)(15) Preparative Procedure In a dry four-neck 250 mL round-bottom flask equipped with a mechanical stirrer, a thermometer, and an argon inlet were introduced at 20 °C triethylamine (21.3 g, 210 mmol), tert-butyl methyl ether (75 mL), and ethanol (9.67 g, 210 mmol). Phosphorus oxychloride (15.3 …
CARMUSTINE
It’s only fair to share… CARMUSTINE Molecular Formula: C5H9Cl2N3O2 Molecular Weight: 214.046 g/mol CAS 154-93-8 Brain tumor; Hodgkins disease; Multiple myeloma; Non-Hodgkin lymphoma 1,3-bis(2-chloroethyl)-3-nitrosourea Urea, 1,3-bis(2-chloroethyl)-1-nitroso- (8CI) N,N’-Bis(2-chloroethyl)-N-nitrosourea 1,3-Bis(2-chlorethyl)-1-nitrosourea 1,3-Bis(2-chloroethyl)-1-nitrosourea 1,3-Bis(2-chloroethyl)nitrosourea 1,3-Bis(β-chloroethyl)-1-nitrosourea BCNU Becenun BiCNU Carmubris Carmustin Carmustine DTI 015 FDA 0345 Gliadel Gliadel Wafer NSC 409962 Nitrumon SK 27702 SRI 1720 Title: Carmustine CAS Registry Number: 154-93-8 …
Funapide, TV 45070, XEN-402, фунапид فونابيد 呋纳匹特
It’s only fair to share… Funapide TV 45070, XEN-402, Funapide, (+)- фунапид فونابيد 呋纳匹特 Molecular FormulaC22H14F3NO5 Average mass429.345 Da (S)-1′-[(5-Methyl-2-furyl)methyl]spiro[6H-furo[3,2-f][1,3]benzodioxole-7,3′-indoline]-2′-one Spiro(furo(2,3-F)-1,3-benzodioxole-7(6H),3′-(3H)indol)-2′(1’H)-one, 1′-((5-(trifluoromethyl)-2-furanyl)methyl)-, (3’S)- (3’S)-1′-((5-(Trifluoromethyl)furan-2-yl)methyl)-2H,6H-spiro(furo(2,3-F)(1,3)benzodioxole-7,3′-indol)-2′(1’H)-one Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3′-[3H]indol]-2′(1’H)-one, 1′-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (7S)- TV-45070 UNII-A5595LHJ2L XEN-401-S XEN402 (3’S)-1′-{[5-(trifluoromethyl)furan-2-yl]methyl}-2H-6H-spiro[furo[2,3-f]-1,3-benzodioxole-7,3′-indol]-2′(1’H)-one (7S)-1′-{[5-(Trifluoromethyl)-2-furyl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1’H)-one 1259933-16-8 CAS UNII-A5595LHJ2L Phase II clinical trials for Postherpetic neuralgia (PHN) Treatment of Neuropathic Pain Originator Xenon Pharmaceuticals Developer Teva Pharmaceutical Industries; Xenon Pharmaceuticals Class Benzodioxoles; Fluorobenzenes; …
Riamilovir, Triazavirin
It’s only fair to share… Riamilovir, Triazavirin Riamilovir sodium dihydrate, CAS 928659-17-0, Riamilovir CAS: 123606-06-4 Chemical Formula: C5H4N6O3S Molecular Weight: 228.19 [1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(1H)-one, 7-(methylthio)-3-nitro- (9CI) 7-(Methylthio)-3-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin-4(6H)-one 1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro- 7-(methylsulfanyl)-3-nitro[1,2,4]triazolo[5,1-c][1,2,4]triazin- 4(1H)-one 7-thio-substituted-3-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazin-4(1H)-one Riamilovir sodium CAS 116061-59-7 Riamilovir sodium dihydrate, CAS 928659-17-0, Triazavirin Flavivirus infection; Zika virus infection Zika virus Flavivirus Anti-viral drug http://apps.who.int/medicinedocs/documents/s23256en/s23256en.pdf Triazavirin (TZV) is a broad-spectrum antiviral drug developed …
Lifitegrast
It’s only fair to share… Lifitegrast, SAR 1118 SAR-1118-023 CAS 1025967-78-5 Xiidra (lifitegrast ophthalmic solution) FDA approves new medication for dry eye disease 07/12/2016 08:48 AM EDT The U.S. Food and Drug Administration approved Xiidra (lifitegrast ophthalmic solution) for the treatment of signs and symptoms of dry eye disease, on Monday, July 11, 2016. Xiidra …
Vaborbactam, Ваборбактам , فابورباكتام , 法硼巴坦 ,
It’s only fair to share… Vaborbactam RN: 1360457-46-0 UNII: 1C75676F8V Molecular Formula. C12-H16-B-N-O5-S Molecular Weight. 297.1374 1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-((2-(2-thienyl)acetyl)amino)-, (3R,6S)- B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)Cc2cccs2)O RPX7009 A beta-lactamase inhibitor. Treatment of Bacterial Infection {(3R,6S)-2-Hydroxy-3-[(2-thienylacetyl)amino]-1,2-oxaborinan-6-yl}acetic acid 2-[(3R,6S)-2-hydroxy-3-[(2-thiophen-2-ylacetyl)amino]oxaborinan-6-yl]acetic acid 1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)- Ваборбактам [Russian] فابورباكتام [Arabic] 法硼巴坦 [Chinese] Originator Rempex Pharmaceuticals Developer The Medicines Company; US Department of Health and Human Services Class Antibacterials; Pyrrolidines; Small molecules; Thienamycins Mechanism …
TOZADENANT
It’s only fair to share… Tozadenant RO-449351 SYN-115 Molecular Formula C19H26N4O4S Average mass 406.499 Da A2 (3); A2a-(3); RO4494351; RO4494351-000; RO4494351-002; SYN-115 Phase III clinical trials at Biotie Therapies for the treatment of Parkinson’s disease as an adjunctive therapy with levodopa 1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl- 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide CAS 870070-55-6 Originator Roche Developer Acorda Therapeutics Class Amides; Antiparkinsonians; Benzothiazoles; Carboxylic acids; …