Drug Approvals International – Page 57 – All about Drugs Live by Dr Anthony Melvin Crasto

Methocarbamol

Methocarbamol Molecular FormulaC11H15NO5 Average mass241.240 Da метокарбамол , ميثوكاربامول , 美索巴莫 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate 208-524-3 [EINECS] 2-Hydroxy-3-(2-methoxyphenoxy)propyl carbamate 532-03-6 [RN] Methocarbamol CAS Registry Number: 532-03-6 CAS Name: 3-(2-Methoxyphenoxy)-1,2-propanediol 1-carbamate Additional Names: 3-(o-methoxyphenoxy)-2-hydroxypropyl 1-carbamate; 2-hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate; guaiacol glyceryl ether carbamate Manufacturers’ Codes: AHR-85 Trademarks: Neuraxin; Miolaxene (Lepetit); Lumirelax; Etroflex; Delaxin (Ferndale); Robamol (Cenci); Traumacut (Brenner-Efeka); Tresortil; Relestrid; Robaxin (Robins) Molecular Formula: C11H15NO5, Molecular Weight: 241.24 Percent Composition: C 54.77%, H 6.27%, …

L-CARNOSINE

L-CARNOSINE Molecular FormulaC9H14N4O3 Average mass226.232 Da (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid (E)-N-(3-Amino-1-hydroxypropylidene)-L-histidine [ACD/IUPAC Name] 206-169-9 [EINECS], 305-84-0 [RN] 8HO6PVN24W カルノシン , Dragosine, Ignotin, Ignotine, Karnozin, L-Carnosine, N-(β-Alanyl)-L-histidine, NSC 524045, Sevitin, β-Alanylhistidine Carnosine CAS Registry Number: 305-84-0 CAS Name: b-Alanyl-L-histidine Additional Names: ignotine Molecular Formula: C9H14N4O3, Molecular Weight: 226.23 Percent Composition: C 47.78%, H 6.24%, N 24.77%, O 21.22% Literature References: Naturally occurring dipeptide found in large amounts in skeletal muscle. Also …

FOMEPIZOLE

FOMEPIZOLE Molecular FormulaC4H6N2 Average mass82.104 Da 4-Methylpyrazole, 4-MP 7554-65-6 [RN] 105204 [Beilstein] 1H-Pyrazole, 4-methyl- 231-445-0 [EINECS] фомепизол , فوميبيزول 甲吡唑 Launched – 1998 EUSA PHARMA Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning.[2] It may be used alone or together with hemodialysis.[2] It is given by injection into a vein.[2] Common side effects include headache, nausea, sleepiness, and unsteadiness.[2] It …

ALLOPURINOL

ALLUPURINOL Molecular FormulaC5H4N4O Average mass136.111 Da аллопуринол [Russian] ألوبيرينول [Arabic] 别嘌醇 [Chinese] 1H-Pyrazolo(3,4-d)pyrimidin-4-ol 2,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one 206-250-9 [EINECS], 315-30-0 [RN] 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-, radical ion(1+) 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,7-dihydro- 691008-24-9 [RN] 7H-Pyrazolo[3,4-d]pyrimidin-4-ol Allopurinol is a medication used to decrease high blood uric acid levels.[2] It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy.[3][4] It is taken by mouth or injected into a vein.[4] Common side …

CITICOLINE

CITICOLINE CDP-choline Molecular FormulaC14H26N4O11P2 Average mass488.324 Da 5′-O-[Hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine 987-78-0 [RN] 1-{5-O-[({Hydroxy[2-(trimethylammonio)ethoxy]phosphoryl}oxy)phosphinato]-β-D-ribofuranosyl}-4-imino-1,4-dihydro-2-pyrimidinol 213-580-7 [EINECS], 2290 2-Pyrimidinol, 1,4-dihydro-1-[5-O-[hydroxy[[hydroxy[2-(trimethylammonio)ethoxy]phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-4-imino-, inner salt Citicoline CAS Registry Number: 987-78-0 CAS Name: Cytidine 5¢-(trihydrogen diphosphate) P¢-[2-(trimethylammonio)ethyl] ester inner salt Additional Names: choline cytidine 5¢-pyrophosphate (ester); cytidine diphosphate choline ester; CDP-choline Trademarks: Difosfocin (Magis); Nicholin (Wyeth); Recognan (Asahi); Rexort (Hoechst); Somazina (Ferrer) Molecular Formula: C14H26N4O11P2, Molecular Weight: 488.32 Percent Composition: C 34.43%, H …

Povidone-iodine

Povidone-iodine PVP 1 UNII85H0HZU99M, BETADINE CAS number 25655-41-8, Molecular Formula, (C6-H9-N-O)x-.x-I2, Molecular Weight, 364.9431 1-ethenylpyrrolidin-2-one;molecular iodine Povidone-Iodine CAS Registry Number: 25655-41-8 CAS Name: 1-Ethenyl-2-pyrrolidinone homopolymer compd with iodine Additional Names: 1-vinyl-2-pyrrolidinone polymers, iodine complex; iodine-polyvinylpyrrolidone complex; polyvinylpyrrolidone-iodine complex; PVP-I Trademarks: Betadine (Purdue Frederick); Betaisodona (Mundipharma); Braunol (Braun Melsungen); Braunosan H (Braun Melsungen); Disadine D.P. (Stuart); Efodine (Fougera); Inadine (J …

4-Hydroxy-TEMPO, TEMPOL, MBM-02, MTS 01

4-Hydroxy-TEMPO, TEMPOL, MBM-02, MTS 01 Molecular FormulaC9H18NO2 Average mass172.245 Da 2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy 2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy radical 2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl CAS 2226-96-2 [RN] 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical 4-Hydroxy-2,2,6,6-tetramethylpiperidine N-oxide 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl TEMPOL CAS Registry Number: 2226-96-2 CAS Name: 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy Additional Names: 4-hydroxy-TEMPO; 4-hydroxy-2,2,6,6-tetramethyl piperidine N-oxide; 4-hydroxy-2,2,6,6-tetramethylpiperidinooxy Molecular Formula: C9H18NO2, Molecular Weight: 172.24 Percent Composition: C 62.76%, H 10.53%, N 8.13%, O 18.58% Literature References: Stable nitroxyl radical; water-soluble analogue of TEMPO, q.v. Functions as a …

Regdanvimab

(Heavy chain) QITLKESGPT LVKPTQTLTL TCSFSGFSLS TSGVGVGWIR QPPGKALEWL ALIDWDDNKY HTTSLKTRLT ISKDTSKNQV VLTMTNMDPV DTATYYCARI PGFLRYRNRY YYYGMDVWGQ GTTVTVSSAS TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKRVEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK (Light chain) ELVLTQPPSV SAAPGQKVTI SCSGSSSNIG NNYVSWYQQL PGTAPKLLIY …

Rabeximod, ROB 803

Rabeximod, ROB 803 C22H24ClN5O, 409.92 2-(9-chloro-2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide CAS 872178-65-9 UNII-J4D3K58W3Z, рабексимод , رابيكسيمود 雷贝莫德 6H-Indolo[2,3-b]quinoxaline-6-acetamide, 9-chloro-N-[2-(dimethylamino)ethyl]-2,3-dimethyl- 872178-65-9 [RN] 8866, J4D3K58W3Z OriginatorOxyPharma DeveloperCyxone; University of California ClassAcetamides; Anti-inflammatories; Disease-modifying antirheumatics; Heterocyclic compounds with 4 or more rings; Small molecules Mechanism of ActionCell differentiation modulators; Macrophage inhibitors Phase IICOVID 2019 infections; Rheumatoid arthritis 12 Oct 2021Cyxone terminates a phase-II trial in COVID-2019 infections in Slovakia …

ZY 19489, MMV 253

ZY 19489, MMV 253 C24 H32 FN9, 465.5 CAS 1821293-40-6 MMV253, GTPL10024, MMV674253 N-(4-cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-5-((3R)-2-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-3,4-dimethylpiperazin-1-yl)pyrimidin-2-amine 2-N-(4-cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-5-[(3R)-3,4-dimethylpiperazin-1-yl]-4-N-(1,5-dimethylpyrazol-3-yl)pyrimidine-2,4-diamine N2-(4-Cyclopropyl-5-fluoro-6-methyl-2-pyridinyl)-5-[(3R)-3,4-dimethyl-1-piperazinyl]-N4-(1,5-dimethyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine (R)-N2-(4-Cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-N4-(1,5-dimethyl-1H-pyrazol-3-yl)-5-(3,4-dimethylpiperazin-1-yl)pyrimidine-2,4-diamine SYN IN 201721031453 The invention relates to triaminopyrimidine compd. of formula I, pharmaceutically acceptable salts thereof, hydrates, solvates, polymorphs, optically active forms thereof, in solid state forms useful for preventing or treating malaria. The invention also relates to a process for prepn. …