It’s only fair to share… Larotrectinib ARRY-470, LOXO-101, PF9462I9HX Molecular Formula: C21H22F2N6O2 Molecular Weight: 428.444 g/mol (3S)-N-{5-[(2R)-2-(2,5-Difluorphenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxy-1-pyrrolidincarboxamid (S)-N-{5-[(R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine-1-carboxamide 10360 1223403-58-4 [RN] UNII:PF9462I9HX ларотректиниб [Russian] [INN] 拉罗替尼 [Chinese] [INN] (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide NTRK-fusion solid tumours TRK inhibitor orphan drug designation in the U.S In 2013, Array Biopharma licensed the product to Loxo Oncology for development and commercialization in the U.S. In 2016, breakthrough therapy …
Cookson’s Dione
It’s only fair to share… Chemical Names: Cyclopentadienebenzoquinone; 1200-89-1; 1,4,4a,8a-Tetrahydro-1,4-methanonaphthalene-5,8-dione; 1,4-Methanonaphthalene-5,8-dione, 1,4,4a,8a-tetrahydro-; NSC 25329; 1,4,4a,8a-Tetrahydro-endo-1,4-methanonaphthalene-5,8-dione Molecular Formula: C11H10O2 Molecular Weight: 174.199 g/mol 1H NMR (CDCl3, 400 MHz) δ = 1.41 (dt, J = 8.8, 1.5 Hz, 1H), 1.52 (dt, J = 8.8, 1.8 Hz, 1H), 3.20 (dd, J = 2.5, 1.5 Hz, 2H), 3.52 (m, …
Cafesterol
It’s only fair to share… Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice https://lnkd.in/e7BxMkg Cafesterol Molecular FormulaC20H28O3 Average mass316.435 Da (1S,4S,12S,13R,16S,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-ol (1S,4S,12S,13R,16S,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-ol (1S,4S,12S,13R,16S,17R)-17-(Hydroxyméthyl)-12-méthyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadéca-5(9),6-dién-17-ol (3bS,5aS,7R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol [3bS-(3ba,5ab,7b,8b-10aa,10bb)]-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]-naphtho[2,1-b]furan-7-methanol Cafesterol 469-83-0 [RN] Scientists identify health benefits of cafestol in coffee Scientists have identified two compounds in coffee – cafestol and caffeic acid – that could …
LY 3104607
It’s only fair to share… LY3104607 (3S)-3-[4-[[2-(2,6-Dimethylphenyl)-[l,2,4]triazolo[l,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic Acid (3S)-3-[4-[[2-(2,6-dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid CAS: 1795232-22-2 Chemical Formula: C27H25N3O3 Molecular Weight: 439.515 (3S)-3-(4-{[2-(2,6-Dimethylphenyl)[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy}phenyl)-4-hexinsäure Benzenepropanoic acid, 4-[[2-(2,6-dimethylphenyl)[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]-β-1-propyn-1-yl-, (βS)- [+]Enlarge Credit: Tien Nguyen/C&EN Presented by: Chafiq Hamdouchi, founder at Hamdouchi Pharmaceutical Consulting Target: G-protein-coupled receptor 40 (GPR40), a receptor that modulates insulin secretion in cells Disease: Type 2 diabetes Reporter’s notes: Developed by Eli Lilly, …
Bedaquiline fumarate, ベダキリンフマル酸塩
It’s only fair to share… Bedaquiline fumarate; Bedaquiline (fumarate); Cas 845533-86-0; UNII-P04QX2C1A5; P04QX2C1A5; Bedaquiline fumarate (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol;(E)-but-2-enedioic acid R 207910 TMC 207 Molecular Formula: C36H35BrN2O6 Molecular Weight: 671.588 g/mol Product SIRTURO (Janssen Products) Formula C32H31BrN2O2. C4H4O4 CAS 845533-86-0 FUMARATE FREE FORM 843663-66-1 Mol weight 671.5769 2018/1/19 PMDA JAPAN APPROVED Bedaquiline fumarate Sirturo Janssen Pharmaceutical ベダキリンフマル酸塩 Bedaquiline …
Baloxavir marboxil, バロキサビルマルボキシル , балоксавир марбоксил , بالوكسافير ماربوكسيل , 玛巴洛沙韦 ,
It’s only fair to share… Baloxavir marboxil バロキサビルマルボキシル балоксавир марбоксил [Russian] [INN] بالوكسافير ماربوكسيل [Arabic] [INN] 玛巴洛沙韦 [Chinese] [INN] Carbonic acid, [[(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl]oxy]methyl methyl ester ({(12aR)-12-[(11S)-7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate (((12aR)-12-((11S)-7,8-Difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-6,8-dioxo-3,4,6,8,12,12ahexahydro-1H-(1,4)oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazin-7-yl)oxy)methyl methyl carbonate Carbonic acid, (((12aR)-12-((11S)-7,8-difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-(1,4)oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazin-7-yl)oxy)methyl methyl ester Antiviral In Japan the product is indicated for treatment influenza types A and B in adults and children RG-6152 UNII-505CXM6OHG Originator Shionogi Developer Roche; Shionogi Class Antivirals; Dibenzothiepins; Esters; …
ELECLAZINE, элеклазин , إيليكلازين , 依来克秦 , REVISITED
It’s only fair to share… ELECLAZINE GS-6615 Molecular Formula: C21H16F3N3O3 Molecular Weight: 415.372 g/mol 1443211-72-0 4-(pyrimidin-2-ylmethyl)-7-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1,4-benzoxazepin-5-one 4-(pyrimidin-2-ylmethyl)-7-[4-(trifluoromethoxy)phenyl]-2,3,4,5- tetrahydro-1,4- benzoxazepin-5-one 7-(4-(Trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one 1,4-Benzoxazepin-5(2H)-one, 3,4-dihydro-4-(2-pyrimidinylmethyl)-7-[4-(trifluoromethoxy)phenyl]- Eleclazine; UNII-PUY08529FK; 1443211-72-0; GS-6615; PUY08529FK; 4-(pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-on элеклазин [Russian] [INN] إيليكلازين [Arabic] [INN] 依来克秦 [Chinese] [INN] Phase III Long QT syndrome INGREDIENT UNII CAS Eleclazine Hydrochloride 4R1JP3Q4HI 1448754-43-5 Eleclazine has been used in trials studying the treatment of LQT2 Syndrome, Long …
Fosravuconazole L-lysine ethanolate, ホスラブコナゾール L－リシンエタノール付加物
It’s only fair to share… C23H20F2N5O5PS▪C6H14N2O2▪C2H6O : 739.73 [914361-45-8] [(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1,2,4-triazol-1-yl)butan-2-yl]oxymethyl dihydrogen phosphate;(2S)-2,6-diaminohexanoic acid;ethanol L-Lysine [[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl]oxy]methyl dihydrogen phosphate ethanol BFE-1224 BMS-379224 E-1224 ravuconazole prodrugs, ravuconazole methyl phosphate fosravuconazole bis(L-lysine) ホスラブコナゾール L－リシンエタノール付加物 Formula C23H20F2N5O5PS. C6H14N2O2. C2H6O CAS 914361-45-8 Mol weight 739.727 Antifungal, Ergosterol biosynthesis inhibitor Fungal infection; Onychomycosis; Trypanosoma cruzi infection PMDA JAPAN APPROVED 2018/1/19 PMDA APPROVED Fosravuconazole L-lysine ethanolate Nailin …
METHYL 2-(ACETYLTHIO)ACETATE
It’s only fair to share… Methyl 2-(methylthio)acetate Molecular FormulaC4H8O2S Average mass120.170 Da 16630-66-3 S-Methylthioglycolate DOI: 10.1021/acs.oprd.7b00378 //////////////// It’s only fair to share…
S-Acetylation of Thiols Mediated by Triflic Acid: A Novel Route to Thioesters
It’s only fair to share… This paper demonstrates an efficient, mild, and chemoselective synthesis of various thioesters via a HOTf-catalyzed S-acetylation of aromatic and aliphatic thiols using isopropenyl acetate as a cheap and convenient acetylating agent. During our tests, we also investigated the differences between the activities of metal triflates and triflic acid as catalysts …