ABACAVIR

Abacavir CAS Registry Number: 136470-78-5 CAS Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Additional Names: (-)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Manufacturers’ Codes: 1592U89 Molecular Formula: C14H18N6O Molecular Weight: 286.33 Percent Composition: C 58.73%, H 6.34%, N 29.35%, O 5.59% Literature References: Nucleoside reverse transcriptase inhibitor (NRTI). Prepn: S. M. Daluge, EP 349242 (1990 to Wellcome Found.); idem, US 5034394 (1991 to Burroughs Wellcome). Asymmetric synthesis: M. T. Crimmins, B. W. King, J. Org. Chem. 61,4192 (1996). Pharmacology and biological profile: S. …

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FDA approves new treatment for hospital-acquired and ventilator-associated bacterial pneumonia

The U.S. Food and Drug Administration today approved a new indication for the previously FDA-approved drug, Zerbaxa (ceftolozane and tazobactam) for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) in patients 18 years and older. The FDA initially approved Zerbaxa in 2014 to treat complicated intra-abdominal infections and for complicated urinary tract …

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Onasemnogene abeparvovec オナセムノジーンアベパルボベック

  Onasemnogene abeparvovec オナセムノジーンアベパルボベック DNA (synthetic adeno-associated virus 9 vector scAAV9.CB.hSMN human survivor motor neuron protein-specifying) Zolgensma FDA 2019/5/24 APPROVED CAS: 1922968-73-7 AVXS-101 Spinal muscular atrophy treatment Treatment of Spinal Muscular Atrophy (SMA) Type 1 Gene therapy product Onasemnogene abeparvovec, sold under the trade name Zolgensma, is a gene therapy medication used to treat spinal muscular atrophy (SMA). SMA is a neuromuscular disorder caused by …

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FDA approves first PI3K inhibitor Piqray (alpelisib) for breast cancer

FDA approves first PI3K inhibitor for breast cancer syn https://newdrugapprovals.org/2018/06/25/alpelisib-byl-719/ Today, the U.S. Food and Drug Administration approved Piqray (alpelisib) tablets, to be used in combination with the FDA-approved endocrine therapy fulvestrant, to treat postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer (as …

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CT-1812

  CT-1812 Elayta Condition(s): Alzheimer’s Disease U.S. FDA Status: Alzheimer’s Disease (Phase 2) Company: Cognition Therapeutics Inc. CAS: 1802632-22-9 Chemical Formula: C24H33NO4S Molecular Weight: 431.591 2-(tert-butoxy)-4-(3-methyl-3-(5-(methylsulfonyl)isoindolin-2-yl)butyl)phenol Phenol, 4-[3-[1,3-dihydro-5-(methylsulfonyl)-2H-isoindol-2-yl]-3-methylbutyl]-2-(1,1-dimethylethoxy)- Originator Cognition Therapeutics Class Antidementias; Neuroprotectants; Nootropics; Small molecules Mechanism of Action Sigma-2 receptor antagonists Phase II Alzheimer’s disease Phase I Cognition disorders 21 Feb 2019 Cognition Therapeutics receives patent for a composition of matter patent …

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Dipivefrine, дипивефрин , ديبيفيفرين , 地匹福林 , ジピベフリン

Dipivefrine Molecular FormulaC19H29NO5 Average mass351.437 Da 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate) 52365-63-6 [RN] (±)-3,4-Dihydroxy-a-[(methylamino)methyl]benzyl Alcohol 3,4-Dipivalate 1-(3′,4′-Dipivaloyloxyphenyl)-2-methylamino-1-ethanol 2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester дипивефрин [Russian] [INN] ديبيفيفرين [Arabic] [INN] 地匹福林 [Chinese] [INN] ジピベフリン 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate D Epifrin [Trade name] Diopine [Trade name] MFCD00673243 [MDL number] Pivalephrine [Trade name] Pro-Epinephrine Propine [Trade name] Thilodrin [Trade name] ATC:S01EA02 Use:antiglaucoma Dipivefrine hydrochloride CAS 64019-93-8  Formula:C19H29NO5 • HCl MW:387.90 g/mol   Dipivefrine (INN) or dipivefrin (USAN), trade name Propine among others, is a prodrug of epinephrine, and is …

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Etosalamide, этосаламид , إيتوسالاميد , 依托柳胺 ,

Etosalamide ethosalamide Cas 15302-15-5 Chemical Formula: C11H15NO3 Molecular Weight: 209.245 o-(2-Ethoxyethoxy)benzamide 1585 1PU994YJUH этосаламид [Russian] [INN] إيتوسالاميد [Arabic] [INN] 依托柳胺 [Chinese] [INN] 2-(2-ethoxyethoxy)benzamide UNII-1PU994YJUH 1PU994YJUH HY-B1015 ZINC3623372 AKOS030526102 CCG-213900 CS-4528 AB01563362_01 SR-01000944263 SR-01000944263-1 Etosalamide, also known as Ethosalamide, is an antipyretic and analgesics agent SYN OR CAS:592-55-2, 2-Bromoethyl ethyl ether Cas, 611-20-1, 2-Hydroxybenzonitrile PATENT DE 1013643 PATENT GB 774635 PATENT US2822391 78 – 79 MP PAPER Journal …

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FDA approves first treatment Ruzurgi (amifampridine) for children with Lambert-Eaton myasthenic syndrome, a rare autoimmune disorder

FDA approves first treatment Ruzurgi (amifampridine)  for children with Lambert-Eaton myasthenic syndrome, a rare autoimmune disorder The U.S. Food and Drug Administration today approved Ruzurgi (amifampridine) tablets for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in patients 6 to less than 17 years of age. This is the first FDA approval of a treatment specifically …

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Beperminogene perplasmid, ベペルミノゲンペルプラスミド

1gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga 51ctagttatta atagtaatca attacggggt cattagttca tagcccatat 101atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc 151gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag 201taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg 251taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc 301ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt 351acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc 401atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg 451atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca 501atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt …

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