It’s only fair to share… SC-52458, FORASARTAN Molecular FormulaC23H28N8 Average mass416.522 Da PHASE 2, PFIZER, HYPERTENSION 145216-43-9 [RN] 5-[(3,5-Dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-yl)phenyl]pyridine 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]pyridine форасартан [Russian] [INN], فوراسارتان[Arabic][INN], 福拉沙坦[Chinese][INN] 065F7WPT0B [DBID] 7415 [DBID] UNII-065F7WPT0B [DBID] SC 52458 [DBID] Type-1 angiotensin II receptor Forasartan, otherwise known as the compound SC-52458, is a nonpeptide angiotensin II receptor antagonist (ARB, AT1 receptor blocker).[2][3][4][5] Forasartan, a specific angiotensin II antagonist, is used alone or with …
Category «Phase 2»
ZYIL 1, Usnoflast
It’s only fair to share… ZYIL 1, Usnoflast All new post MARCH 2025 2455519-86-3 [ZYDUS CADILA] ZYIL1 ZYIL-1 ZY-IL1 C21H29N3O3S Ethenesulfonamide, 2-[(2R)-1,2-dimethyl-2-pyrrolidinyl]-N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-, (1E)- MW 403.54 (1E)-2-[(2R)-1,2-Dimethyl-2-pyrrolidinyl]-N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]ethenesulfonamide PATENTS European Journal of Pharmacology (2023), 957, 175931 WO2020148619 CADILA WO2023026222 ZYDUS WO2023281455 ZYDUS US-2022169605 EP-3911631-A1 JP-2022517113-A SCHEME https://patents.google.com/patent/WO2020148619A1/enhttps://patents.google.com/patent/WO2020148619A1/en WO2020148619 Intermediate-9: Preparation of l-(diphenylphosphoryl)-N-((l,2,3,5,6,7- hexahydro-s-indacen-4-yl)carbamoyl)methanesulfonamide (diphenylphosphoryl)methanesulfonamide [Intermediate 8] (6.0 …
Camizestrant, AZD 9833
It’s only fair to share… Camizestrant, AZD 9833 AZ 14066724 PHASE 2 CAS: 2222844-89-3 Chemical Formula: C24H28F4N6 Exact Mass: 476.2312 Molecular Weight: 476.5236 Elemental Analysis: C, 60.49; H, 5.92; F, 15.95; N, 17.64 N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine AZ14066724 AZD-9833 AZD9833 Camizestrant UNII-JUP57A8EPZ WHO 11592 OriginatorAstraZeneca ClassAmines; Antineoplastics; Azetidines; Fluorinated hydrocarbons; Isoquinolines; Pyrazolones; Pyridines; Small molecules Mechanism …
ARIMOCLOMOL
It’s only fair to share… ARIMOCLOMOL アリモクロモル; Formula C14H20ClN3O3 Exact mass 313.1193 Mol weight 313.7799 CAS 289893-25-0 289893-26-1 (Arimoclomol maleate); INN 8300 N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride BRX 220 FDA APPROVED, 9/20/2024, Miplyffa, To treat Niemann-Pick disease type C Press Release Drug Trials Snapshot Arimoclomol maleate is in a phase III clinical trials by Orphazyme for the treatment of …
Rabeximod, ROB 803
It’s only fair to share… Rabeximod, ROB 803 C22H24ClN5O, 409.92 2-(9-chloro-2,3-dimethylindolo[3,2-b]quinoxalin-6-yl)-N-[2-(dimethylamino)ethyl]acetamide CAS 872178-65-9 UNII-J4D3K58W3Z, рабексимод , رابيكسيمود 雷贝莫德 6H-Indolo[2,3-b]quinoxaline-6-acetamide, 9-chloro-N-[2-(dimethylamino)ethyl]-2,3-dimethyl- 872178-65-9 [RN] 8866, J4D3K58W3Z OriginatorOxyPharma DeveloperCyxone; University of California ClassAcetamides; Anti-inflammatories; Disease-modifying antirheumatics; Heterocyclic compounds with 4 or more rings; Small molecules Mechanism of ActionCell differentiation modulators; Macrophage inhibitors Phase IICOVID 2019 infections; Rheumatoid arthritis 12 Oct 2021Cyxone terminates a phase-II trial …
AUPM 170, CA 170, PD-1-IN-1
It’s only fair to share… (2S,3R)-2-(3-((S)-3-amino-1-(3-((R)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)ureido)-3-hydroxybutanoic acid Molecular Weight (MW) 360.33 Formula C12H20N6O7 CAS No. 1673534-76-3 N-[[[(1S)-3-Amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]-L-threonine L-Threonine, N-[[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]amino]carbonyl]- AUPM 170, CA 170, AUPM-170, CA-170, PD-1-IN-1 Novel inhibitor of programmed cell dealth-1 (PD-1) CA-170 (also known as AUPM170 or PD-1-IN-1) is a first-in-class, potent and orally available small molecule inhibitor of the immune checkpoint regulatory proteins PD-L1 …
AUR 101
Pralnacasan
It’s only fair to share… Pralnacasan VX 740 cas 192755-52-5 (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide N-[(4S,7S)-4-{[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]carbamoyl}-6,10-dioxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-yl]isoquinoline-1-carboxamide (1S,9S)-N-((2R,3S)-2-Ethoxy-5-oxotetrahydrofuran-3-yl)-9-((isoquinolin-1-ylcarbonyl)amino)-6,10-dioxooctahydro-6-H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxamide, N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)amino)-6,10-dioxo-, (1S,9S)- HMR 3480 HMR3480 HMR3480/VX-740 Pralnacasan UNII-N986NI319S VX 470 VX-740 C26H29N5O7, 523.543 NSAID, ICE inhibitor & metastasis inhibitor. пралнаказан [Russian] [INN] برالناكاسان [Arabic] [INN] 普那卡生 [Chinese] [INN] Pralnacasan is an orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE). Pralnacasan is …
VX 148
It’s only fair to share… VX 148 297730-05-3 Name: VX-148 CAS#: 297730-05-3 Chemical Formula: C23H25N5O4 Exact Mass: 435.19065 Molecular Weight: 435.48 Elemental Analysis: C, 63.44; H, 5.79; N, 16.08; O, 14.70 Molecular Weight 435.48 Formula C23H25N5O4 CAS No. 297730-05-3 (VX 148); Chemical Name Carbamic acid, N-[(1S)-1-[3-[[[(4-cyano-3-methoxyphenyl)amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester MOA：Inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitorIndication：PsoriasisStatus：Phase Ⅱ (Discontinued)Company：Vertex (Originator) …
VX- ? (3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide)
It’s only fair to share… VX- ? CAS 2446817-72-5 HYDRATE 2446818-26-2 Acetic acid, 1-methylethyl ester 2446818-27-3 C21 H20 F N3 O3, 381.4 1H-Indole-3-propanamide, 2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]- 3-[2-(4-fluorophenyl)-lH-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2- oxo-pyrrolidin-3-yl ] propanamide use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD). PATENT WO/2021/158666 SOLID FORMS OF APOL1 INHIBITOR AND METHODS OF USING SAME Compound I is disclosed as Compound 87 …