It’s only fair to share… Lanabecestat Molecular FormulaC26H28N4O Average mass412.527 Da Dispiro[cyclohexane-1,2′-[2H]indene-1′(3′H),2”-[2H]imidazol]-4”-amine, 4-methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1′R,4β)- (1r,1’R,4R)-4-Methoxy-5”-methyl-6′-[5-(1-propin-1-yl)-3-pyridinyl]-3’H-dispiro[cyclohexane-1,2‘-indene-1’,2”-imidazol]-4”-amin (1r,1’R,4R)-4-Methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]-3’H-dispiro[cyclohexane-1,2‘-indene-1’,2”-imidazol]-4”-amine (lr,l’R,4R)- 4-methoxy-5″-methyl-6′-[5-(prop-l-yn-l-yl)pyridin-3-yl]-3’H- dispiro[cyclohexane-l,2′-inden-l’2′-imidazole]-4″-amine (lr,4r)-4-Methoxy-5″-methyl-6′-(5-prop-l-yn-l-ylpyridin-3-yl)-3’H-dispiro[cyclohexane- l,2′-indene-l’,2″-imidazol]- “-amine CAS 1383982-64-6 AZD3293 Dispiro[cyclohexane-1,2′-[1H]indene-1′(3’H),2”-[2H]imidazol]-4”-amine, 4-methoxy-5”-methyl-6‘-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1‘R)- Lanabecestat LY3314814 UNII:X8SPJ492VF, AZ-12304146 Beta amyloid antagonist; Beta secretase 1 inhibitor; Beta secretase 2 inhibitor Fast Track (1α,1’R,4β)-4-Methoxy-5”-methyl-6′-[5-(1-propyn-1-yl)-3-pyridinyl]dispiro[cyclohexane-1,2′-[2H]indene-1′(3’H),2”-[2H]imidazol]-4”-amine (1,4-trans,1’R)-4-methoxy-5”-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2′-indene-1′,2”-imidazol]-4”-amine (1r,1’R,4R)-4-methoxy-5”-methyl-6′-[5-(prop-1-yn-1-yl)pyridin-3-yl]-3’H-dispiro[cyclohexane-1,2′-indene-1′,2”-imidazol]-4”-amine Lanabecestat (formerly known as AZD3293 or LY3314814) is …
Category «PHASE 3»
Pridopidine
It’s only fair to share… Pridopidine Molecular Formula C15H23NO2S Average mass 281.414 Da 346688-38-8 CAS FREE FORM 882737-42-0 (hydrochloride) 1440284-30-9 HBr 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidin 4- (3 -Methanesulfonyl-phenyl ) – 1-propyl -piperidine ACR16 Huntexil UNII-HD4TW8S2VK; 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine ACR 16 ASP 2314 FR 310826 Huntingtons chorea Dopamine D2 receptor antagonist; Opioid receptor sigma agonist 1 Neurosearch INNOVATORS, In 2012, the product was acquired by …
Plinabulin
It’s only fair to share… Plinabulin Molecular FormulaC19H20N4O2 Average mass336.388 Da (3Z,6Z)-3-Benzylidène-6-{[4-(2-méthyl-2-propanyl)-1H-imidazol-5-yl]méthylène}-2,5-pipérazinedione 2,5-Piperazinedione, 3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)-, (3Z,6Z)- CAS 714272-27-2 NPI 2358 NPI-2358; NPI 2358 UNII:986FY7F8XR Phase 3 Clinical Tubulin antagonist Cancer; Febrile neutropenia; Non-small-cell lung cancer Plinabulin (chemical structure, BPI-2358, formerly NPI-2358) is a small molecule under development by BeyondSpring Pharmaceuticals, and is in a world-wide Phase …
Pexidartinib, PLX-3397
It’s only fair to share… Pexidartinib PLX-3397 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine 5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine hydrochloride Phase III A Multi-targeted tyrosine kinase inhibitor potentially for the treatment of tenosynovial giant cell tumor (TGCT). CAS 1029044-16-3 C20H15ClF3N5, 417.81 Pexidartinib; 1029044-16-3; PLX-3397; 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine; 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine; 5-[(5-Chloro-1h-Pyrrolo[2,3-B]pyridin-3-Yl)methyl]-N-{[6-(Trifluoromethyl)pyridin-3-Yl]methyl}pyridin-2-Amine; Originator Plexxikon Developer Barbara Ann Karmanos Cancer Institute; Columbia University; Merck & Co; National Cancer Institute (USA); Plexxikon; University …
Idasanutlin, RG-7388, идасанутлин ,إيداسانوتلين , 依达奴林
It’s only fair to share… Idasanutlin(RG-7388) cas 1229705-06-9 идасанутлин [Russian] إيداسانوتلين [Arabic] 依达奴林 [Chinese] 4-{ [(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2- dimethyl-prop yl)-pyrrolidine-2-carbonyl] -amino }-3-methoxy-benzoic acid (C31H29Cl2F2N304) 4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid MW 616.4973 F. Hoffmann-La Roche Ag, Hoffmann-La Roche Inc.ROCHE PHASE1 for the oral treatment of cancer, including solid tumors and hematological tumors, including acute myelogenous leukemia Acute myelogenous leukemia; Cancer; Prostate …
Pibrentasvir, ABT-530, A 1325912.0
It’s only fair to share… Pibrentasvir ABT-530, Pibrentasvir, A 1325912.0 Dimethyl N,N’-([(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl}pyrrolidine-2,5-diyl]bis{(6-fluoro-1H-benzimidazole-5,2-diyl)[(2S)-pyrrolidine-2,1-diyl][(2S,3R)-3-methoxy-1-oxobutane-1,2-diyl]})biscarbamate Methyl {(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl}-5-(6-fluoro-2-{(2S)-1-[N-(methoxycarbonyl)-O-methyl-L-threonyl]pyrrolidin-2-yl}-1H-benzimidazol-5-yl)pyrrolidin-2-yl]-6-fluoro-1H-benzimidazol-2-yl}pyrrolidin-1-yl]-3-methoxy-1-oxobutan-2-yl}carbamate Dimethyl N,N’-(((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis((6-fluoro-1H-benzimidazole-5,2-diyl)((2S)-pyrrolidine-2,1-diyl)((2S,3R)-3-methoxy-1-oxobutane-1,2-diyl)))biscarbamate Methyl ((2S,3R)-1-((2S)-2-(5-((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)-5-(6-fluoro-2-((2S)-1-(N-(methoxycarbonyl)-O-methyl-L-threonyl)pyrrolidin-2-yl)-1H-benzimidazol-5-yl)pyrrolidin-2-yl)-6-fluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl)-3-methoxy-1-oxobutan-2-yl)carbamate Phase III Abbott Laboratories INNOVATOR A protease inhibitor potentially for the treatment of HCV infection. Hepatitis C virus NS 5 protein inhibitors CAS No. 1353900-92-1 MF C57H65F5N10O8 MW 1113.1925 MW Pibrentasvir UNII-2WU922TK3L CLINICAL https://clinicaltrials.gov/search/intervention=A-1325912.0%20OR%20ABT-530%20OR%20Pibrentasvir Pibrentasvir SYNTHESIS PATENT WO 2012051361 http://www.google.com/patents/WO2012051361A1?cl=en Example …
VADADUSTAT, вададустат , فادادوستات , 伐达度司他 ,
It’s only fair to share… VADADUSTAT AKB-6548, PG-1016548 PG1016548, UNII:I60W9520VV, B-506 CAS 1000025-07-9 [5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxamido]acetic acid N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine MF C14H11ClN2O4 , 306.0407 вададустат [Russian] [INN] فادادوستات [Arabic] [INN] 伐达度司他 [Chinese] [INN] 2-(5-(3-Chlorophenyl)-3-hydroxypicolinamido)acetic acid A1Z N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycine US8598210, 118 [5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxamido]acetic acid 1000025-07-9 [RN] 10289 AKB-6548 Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- [ACD/Index Name] I60W9520VV N-[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]glycine N-{[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl}glycine [ACD/IUPAC Name] PG1016548 UNII:I60W9520VV Inventors Richard Kawamoto Original Assignee The Procter & Gamble Company for Treatment of Anemia associated …
Evofosfamide, эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 ,
It’s only fair to share… Evofosfamide, HAP-302 , TH-302, TH 302 эвофосфамид , إيفوفوسفاميد , 艾伏磷酰胺 , Molecular Formula C9H16Br2N5O4P Average mass 449.036 Da (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N’-bis(2-bromoethyl)phosphorodiamidate (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl-N,N’-bis(2-bromethyl)phosphorodiamidat 918633-87-1 TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs Originator Threshold Pharmaceuticals Developer Merck KGaA; Threshold Pharmaceuticals Class Antineoplastics; Nitroimidazoles; Phosphoramide mustards; Small …