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PERAMIVIR

PERAMIVIR CAS 330600-85-6 Molecular FormulaC15H28N4O4 Average mass328.407 Da (1S,2S,3R,4R)-4-carbamimidamido-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid RWJ 270201 RWJ-270201 RWJ270201 (1S,2S,3R,4R)-3-(1-Acetamido-2-ethylbutyl)-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid [ACD/IUPAC Name] (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic Acid (1S,2S,3R,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid 229614-56-6 [RN] 330600-85-6 [RN] 8184 9ZS94HQO3B Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase …

IDEBENONE

IDEBENONE 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone Molecular FormulaC19H30O5 Average mass338.439 Da 58186-27-9 Idebenona, Idebenonum, CV 2619 Idesol KS-5193 Nemocebral SNT-MC17 идебенон إيديبينون 艾地苯醌 Puldysa (idebenone), for the treatment of Duchenne muscular dystrophy Title: Idebenone CAS Registry Number: 58186-27-9 CAS Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione Additional Names: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone; 2,3-dimethoxy-5-methyl-6-(10¢-hydroxydecyl)-1,4-benzoquinone; 6-(10-hydroxydecyl)ubiquinone Manufacturers’ Codes: CV-2619 Trademarks: Avan (Takeda); Daruma (Takeda); Lucebanol (Hormona); Mnesis (Takeda) Molecular Formula: C19H30O5 Molecular Weight: 338.44 Percent Composition: C 67.43%, H 8.93%, O …

PF 3635659

PF-3635659 CAS 931409-24-4 FREE FORM Molecular Formula, C28-H32-N2-O3, Molecular Weight, 444.5718 1-Azetidinepentanamide, 3-(3-hydroxyphenoxy)-delta,delta-dimethyl-alpha,alpha-diphenyl- 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide;hydrochloride Molecular Formula C28H33ClN2O3 Synonyms PF-3635659 (hydrochloride) 1079781-31-9 5-[3-(3-Hydroxy-phenoxy)-azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanoic acid amide hydrochloride Molecular Weight 481 g/mol READ www.soci.org › David_Price_Presentation_0945_1030 PDF Discovery of PF–3635659. An Inhaled Once. An Inhaled Once-daily M3. A t. i t. A t. i t f A th & COPD f …

BINDARIT

BINDARIT Molecular FormulaC19H20N2O3 Average mass324.374 Da CAS 130641-38-2 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1 -benzyl-1 H-indazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid JQ11LH711M Propanoic acid, 2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]- [ACD/Index Name] биндарит [Russian] [INN] بينداريت [Arabic] [INN] 宾达利 [Chinese] [INN] PHASE 2 Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss …

Dofetilide

Dofetilide 115256-11-6 [RN] 6756 b-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]- MFCD00869707 [MDL number] Molecular FormulaC19H27N3O5S2 Average mass441.565 Da UK68798 UNII:R4Z9X1N2ND UNII-R4Z9X1N2ND Xelide β-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide дофетилид دوفيتيليد 多非利特 N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide NCGC00164549-01 PB0478000 SMR000466333 Tikosyn (TN) Research Code：UK-68798 Trade Name：Tikosyn® MOA：Atrial potassium channel blocker Indication：Atrial flutter; Atrial fibrillation Status：ApprovedCompany：Pfizer (Originator)Sales： ATC Code：C01BD04 INDIA 31/7/2020 APPROVED CDSCO Dofetilide was first approved by the U.S. Food and Drug …

VILDAGLIPTIN

VILDAGLIPTIN Molecular FormulaC17H25N3O2 Average mass303.399 Da (2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}pyrrolidine-2-carbonitrile (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile (2S)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile 274901-16-5 [RN] 2-Pyrrolidinecarbonitrile, 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)- (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile Vildagliptin was approved by the European Medicines Agency (EMA) on Sep 26, 2007, and approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on Jan 20, 2010, following by China Food and Drug Administration (CFDA) on Aug 15, 2011. It …

Catequentinib, Anlotinib

Catequentinib C23H22FN3O3 407.4 g/mol 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinolin-7-yl]oxymethyl]cyclopropan-1-amine 1058156-90-3 CAS No. 1360460-82-7 DI HCL Molecular Weight 480.36 Formula C23H22FN3O3 • 2HCl Anlotinib AL3818 UNII-GKF8S4C432 Chia Tai Tianqing Pharmaceutical Group Co Ltd Launched (Metastatic non small cell lung cancer – China – May-2018) Orphan Drug; Priority Review MOA：VEGFR inhibitor Indication：advanced gastric adenocarcinoma; Advanced renal cell carcinoma (RCC); Medullary thyroid cancer (MTC); Metastatic colorectal cancer (CRC); Non …

Lurbinectedin

Lurbinectedin (1’R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-2′,3′,4′,6,6a,7,9′-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-spiro(6,16-(epithiopropaneoxymethano)-7.13-imino-12H-1,3-dioxolo[7,8]soquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one Molecular Weight 784.87 Formula C41H44N4O10S CAS No. 497871-47-3 (Lurbinectedin); Chemical Name Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2′,3′,4′,6,6a,7,9′,13,14,16-decahydro-8,14-dihydroxy-6′,9-dimethoxy-4,10,23-trimethyl-, (1’R,6R,6aR,7R,13S,14S,16R)- (9CI) fda approved , 6/15/2020 , ZEPZELCA, Pharma Mar S.A. To treat metastatic small cell lung cancer Drug Trials Snapshot Research Code：PM-01183; PM-1183 MOA：RNA polymerase inhibitor Indication：Ovarian cancer; Breast cancer; Non small cell lung cancer (NSCLC) лурбинектедин لوربينيكتيدين 芦比替定 (1R,1’R,2’R,3’R,11′S,12’S,14’R)-5′,12′-Dihydroxy-6,6′-dimethoxy-7′,21′,30′-trimethyl-27′-oxo-2,3,4,9-tetrahydrospiro[β-carboline-1,26‘-[17,19,28]trioxa[24]thia[13,30]diazaheptacyclo[12.9.6.13,11. 02,13.04,9.015,23.016,20]triaconta[4,6,8,15,20,22]hexaen]-22′-yl acetate [ACD/IUPAC Name] 2CN60TN6ZS …

Naxitamab

(Heavy chain) QVQLVESGPG VVQPGRSLRI SCAVSGFSVT NYGVHWVRQP PGKGLEWLGV IWAGGITNYN SAFMSRLTIS KDNSKNTVYL QMNSLRAEDT AMYYCASRGG HYGYALDYWG QGTLVTVSSA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK (Light chain) EIVMTQTPAT LSVSAGERVT ITCKASQSVS NDVTWYQQKP GQAPRLLIYS ASNRYSGVPA …

PLECANATIDE

Plecanatide Molecular FormulaC65H104N18O26S4 Average mass1681.886 Da плеканатид [Russian] [INN] بليكاناتيد [Arabic] [INN] 普卡那肽 [Chinese] [INN] 7IK8Z952OK Guanilib L-Asparaginyl-L-α-aspartyl-N-{(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-22-(2-carboxyethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-32-[(1R)-1-hydroxyethyl]-19-isobut yl-7,13-diisopropyl-4-methyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracont-25-yl}-L-α-glutamine L-α-Glutamine, L-asparaginyl-L-α-aspartyl-N-[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-22-(2-carboxyethyl)-38-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]-32-[(1R)- 1-hydroxyethyl]-4-methyl-7,13-bis(1-methylethyl)-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracont-2 5-yl]- PLECANATIDE; UNII-7IK8Z952OK; (3-Glutamic acid(D>E))human uroguanylin (UGN); 467426-54-6; Molecular Formula: C65H104N18O26S4 Molecular Weight: 1681.88626 g/mol IUPAC Condensed H-Asn-Asp-Glu-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH (2S)-2-[[(1R,4S,7S,10S,13S,16R,21R,27S,34R,37S,40S)-10-(2-amino-2-oxoethyl)-34-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-37-(2-carboxyethyl)-27-[(1R)-1-hydroxyethyl]-4-methyl-40-(2-methylpropyl)-3,6,9,12,15,23,26,29,35,38,41-undecaoxo-7,13-di(propan-2-yl)-18,19,31,32-tetrathia-2,5,8,11,14,22,25,28,36,39,42-undecazabicyclo[14.13.13]dotetracontane-21-carbonyl]amino]-4-methylpentanoic acid L-Leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L- cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4->12),(7->15)-bis(disulfide) L-Asparaginyl-L-α-aspartyl-N-{(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-22-(2-carboxyethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-32-[(1R)-1-hydroxyethyl]-19-isobut yl-7,13-diisopropyl-4-methyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracont-25-yl}-L-α-glutamine Plecanatide RN: 467426-54-6 Molecular FormulaC65H104N18O26S4 Average mass1681.886 Da 105: PN: WO2012037380 SEQID: …