It’s only fair to share… Setidegrasib CAS 2821793-99-9 MF C60H65FN12O7S MW1117.30 (2S,4R)-1-[(2S)-2-[4-[4-[[6-cyclopropyl-4-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-2-(oxan-4-yloxy)quinazolin-8-yl]oxymethyl]phenyl]triazol-1-yl]-3-methylbutanoyl]-4-hydroxy-N-[(1R)-2-hydroxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide Kirsten rat sarcoma viral oncogene homologue (KRAS) degradationinducer, antineoplastic, ASP-3082, ASP 3082, 3NQ4ME292X, KRAS G12D inhibitor 17 Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity …
Sendegobresib
It’s only fair to share… Sendegobresib CAS 2704617-96-7 MFC37H45F3N6O5, 710.79 2,6-PIPERIDINEDIONE, 3-((4-(4-((4S)-1-((4-(1,6-DIHYDRO-1,4,5-TRIMETHYL-6-OXO-3-PYRIDINYL)-2,6-DIMETHOXYPHENYL)METHYL)-3,3-DIFLUORO-4-PIPERIDINYL)-1-PIPERAZINYL)-3-FLUOROPHENYL)AMINO)-, (3S)- (3S)-3-[4-[4-[(4S)-1-[[2,6-dimethoxy-4-(1,4,5-trimethyl-6-oxo-3-pyridinyl)phenyl]methyl]-3,3-difluoropiperidin-4-yl]piperazin-1-yl]-3-fluoroanilino]piperidine-2,6-dione bromodomain-containing protein 9 (BRD9) degradation inducer, antineoplastic, AW8PEP3VZ3, CFT 8634, ORPHAN DRUG Sendegobresib is an orally bioavailable heterobifunctional protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. Sendegobresib is comprised of an E3 …
Segigratinib, Ratangratinib
It’s only fair to share… Segigratinib, Ratangratinib CAS 1882873-93-9 MF C27H28Cl2N6O3 MW 555.5 g/mol N-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(3,3-dimethylpiperazin-1-yl)benzamide N-[6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[5,4-b]pyridin-3-yl]-4-(3,3-dimethylpiperazin-1-yl)benzamidefibroblast growth factor receptor tyrosine kinase inhibitor, antineoplastic, 3D 185, Ratangratinib, 3D-185, G0Z5E4YTB4, HH 185 Ratangratinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3) and colony stimulating factor 1 receptor (CSF1R; …
Segatroxaban
It’s only fair to share… Segatroxaban CAS 1184300-63-7 MF C24H30ClN5O5S2 MW568.11 5-chloro-N-{(2S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzene1-sulfonamido]-3-(4-methylpiperazin-1-yl)-3-oxopropyl}thiophene-2-carboxamide 2-THIOPHENECARBOXAMIDE, 5-CHLORO-N-((2S)-2-(((2-METHYL-3-(2-OXO-1-PYRROLIDINYL)PHENYL)SULFONYL)AMINO)-3-(4-METHYL-1-PIPERAZINYL)-3-OXOPROPYL)-5-CHLORO-N-((2S)-2-(((2-METHYL-3-(2-OXO-1-PYRROLIDINYL)PHENYL)SULFONYL)AMINO)-3-(4-METHYL-1-PIPERAZINYL)-3-OXOPROPYL)-2-THIOPHENECARBOXAMIDE5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID N-((S)-2-(((2-METHYL-3-(2-OXOPYRROLIDIN-1-YL)PHENYL)SULFONYL)AMINO)-3-(4-METHYLPIPERAZIN-1-YL)-3-OXOPROPYL)AMIDE5-CHLORO-N-((2S)-2-(2-METHYL-3-(2-OXOPYRROLIDIN-1-YL)BENZENE-1-SULFONAMIDO)-3-(4-METHYLPIPERAZIN-1-YL)-3-OXOPROPYL)THIOPHENE-2-CARBOXAMIDEblood coagulation factors Xa and IIa (thrombin) inhibitor, 53FM6EUY9U, SAR107375, SAR 107375 SYN WO-2009103440 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009103440&_cid=P10-MILGON-12468-1 SYN WO-2014174102-A1 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014174102&_cid=P10-MILGJE-09654-1 SYN WO-2023031083-A1 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2023031083&_cid=P10-MILGQR-13553-1 PAT Chlorothiophene-amides as inhibitors of coagulation factors xa and thrombin Publication Number: WO-2009103440-A1 Priority Date: 2008-02-21 AS ON OCT2025 4.511 LAKHS …
Rupitasertib
It’s only fair to share… Rupitasertib CAS 1379545-95-5 MF C21H19ClF3N5O 449.9 g/mol 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide 4-[[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]quinazoline-8-carboxamideserine/ threonine kinase inhibitor, antineoplastic, EMD SERONO, Gastric cancer; HER2 positive breast cancer; Solid tumours, M2698 HCl, M2698 hydrochloride, MSC2363318A, MSC 2363318A, MSC-2363318A, M2698, M-269, M 2698. Rupitasertib HCl, 0DXG50I4WD Rupitasertib is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase …
Rogocekib
It’s only fair to share… Rogocekib CAS 2144751-78-8 MF C19H17FN8O2 MW 408.39 1-({5-[(1R)-1-fluoroethyl]-1,3,4-oxadiazol-2-yl}methyl)-6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methyl1H-imidazo[4,5-b]pyridine 2-[(1R)-1-fluoroethyl]-5-[[6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methylimidazo[4,5-b]pyridin-1-yl]methyl]-1,3,4-oxadiazoledual specificity protein kinase CLK (CDC2-like kinase)inhibitor, antineoplastic, CTX 712, XE88VQP94E Rogocekib is an orally effective CLK 2 inhibitor, with an IC50 of 1.4 nM, showing anti-tumor activity. Rogocekib is an orally bioavailable inhibitor of CLK family kinases, with potential antineoplastic activity. Upon oral administration, rogocekib binds …
Riselcaftor
It’s only fair to share… Riselcaftor CAS 2799652-36-9 MF C29H28N2O5S MW 516.61 (2R,4R)-2-(2-methoxy-5-methylphenyl)-N-(2-methylquinoline-5-sulfonyl)-4-phenyloxolane-2-carboxamide (2R,4R)-2-(2-methoxy-5-methylphenyl)-N-(2-methylquinolin-5-yl)sulfonyl-4-phenyloxolane-2-carboxamidecystic fibrosis transmembrane regulator (CFTR)protein modulator, 726GWJ6KQQ Riselcaftor (Example 33) is a CFTR modulator, with an EC50 of 20.1 nM in human bronchial epithelial cells. Riselcaftor can be used for research of cystic fibrosis. SYN US20220211692 https://patentscope.wipo.int/search/en/detail.jsf?docId=US367940046&_cid=P11-MIH63N-23616-1 Example 33 (2R,4R)-2-(2-methoxy-5-methylphenyl)-N-(2-methylquinoline-5-sulfonyl)-4-phenyloxolane-2-carboxamide The enantiomers of Example 32D …
Pudafensine
It’s only fair to share… Pudafensine CAS 1320346-14-2 MFC17H19NO4 MW 301.34 g/mol 7-{[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]oxy}-3-methoxy2H-1-benzopyran-2-onemonoamine reuptake inhibitor, erectile dysfunction, neuropathic pain, NS18313, NS 18313, L9NG7US8GE, IP2015, IP 2015 Pudafensine is a monoamine reuptake inhibitor being developed as a potential treatment for erectile dysfunction (ED) and neuropathic pain. As a drug candidate, it works by preferentially inhibiting the reuptake of dopamine and serotonin. …
Privosegtor
It’s only fair to share… Privosegtor CAS 1361200-34-1 MF C25H38FN5O4, MW 491.6 g/mol GLYCINAMIDE, N-(2-(2-FLUOROPHENYL)ETHYL)GLYCYL-N-(2-METHYLPROPYL)GLYCYL-N2-(3-(2-OXO-1-PYRROLIDINYL)PROPYL)-N-(2-(2-FLUOROPHENYL)ETHYL)GLYCYL-N-(2-METHYLPROPYL)GLYCYL-N2-(3-(2-OXO-1-PYRROLIDINYL)PROPYL)GLYCINAMIDEN-(2-(2-FLUOROPHENYL)ETHYL)GLYCYL-N-(2-METHYLPROPYL)GLYCYL-N2-(3-(2-OXOPYRROLIDIN-1-YL)PROPYL)GLYCINAMIDE N-[2-(2-fluorophenyl)ethyl]glycyl-N-(2-methylpropyl)glycyl-N2[3-(2-oxopyrrolidin-1-yl)propyl]glycinamideserum/ glucocorticoid-regulated kinase 2 (Sgk2) activator, Phase 2, Optic neuritis, orphan drug, BN-201, BN 201, G-79, G 79, KCN37L7EIH OCS-05 in Patients With Optic Neuritis CTID: NCT04762017 Phase: Phase 2 Status: Completed Date: 2025-09-22 N-[2-[(2-amino-2-oxoethyl)-[3-(2-oxopyrrolidin-1-yl)propyl]amino]-2-oxoethyl]-2-[2-(2-fluorophenyl)ethylamino]-N-(2-methylpropyl)acetamide (BN201) is a small peptide molecule, a first-in-class neuroprotective compound. …
Pregabalin naproxencarbil
It’s only fair to share… Pregabalin naproxencarbil CAS 1221072-91-8 MF C25H33NO7 MW459.5 g/mol (3S)-3-[({[(1R)-1-{[(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxy}ethoxy]carbonyl}amino)methyl]-5-methylhexanoic acid (3S)-3-[[[(1R)-1-[(2S)-2-(6-methoxynaphthalen-2-yl)propanoyl]oxyethoxy]carbonylamino]methyl]-5-methylhexanoic acidgabamimetic, analgesic, ZVG8DDT3FJ PAT WO-2019219000 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019219000&_cid=P22-MID0L3-49648-1 Example 1: Exemplary synthesis of the compound of Formula I and crystallization thereof Step A: Synthesis of 1-chloroethyl 2-fluorophenyl carbonate (3) [0306] A suitable reaction vessel was charged with water and sodium bicarbonate followed …