It’s only fair to share… tert-Butyl 4-(2,3-diaminophenyl)piperazine-1- carboxylate (4) 1H NMR (400 MHz, CDCl3), δ in ppm = 6.68 (t, 1H), 6.59 (d, J = 8.8 Hz, 1H), 6.55 (d, J = 7.6 Hz, 1H), 3.56 (br s, 8H), 2.83 (s, 4H), 1.49 (s, 9H). This is consistent with literature data.1 Small molecule piperazinyl-benzimidazole …
Ubrogepant, MK-1602
It’s only fair to share… Ubrogepant, MK-1602 (S)-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide (3’S)-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2′-oxo-1′,2‘,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide (6S)-N-[(3S,5S,6R)-6-Methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl]-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide Spiro[6H-cyclopenta[b]pyridine-6,3′-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide, 1′,2′,5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl]-2′-oxo-, (6S)- CAS: 1374248-77-7 Chemical Formula: C29H26F3N5O3 Molecular Weight: 549.5542 UNII-AD0O8X2QJR CAS TRIHYDRATE 1488325-95-6 CAS MONOHYDRATE 1488327-13-4 Originator Merck & Co Class Amides; Antimigraines; Fluorine compounds; Small molecules; Spiro compounds Mechanism of Action Calcitonin gene-related peptide receptor antagonists Phase III Migraine, Allergan Most Recent Events 01 Sep 2016 Allergan initiates a …
Nefopam Hydrochloride, Нефопама Гидрохлорид, 塩酸ネホパム
It’s only fair to share… Nefopam Molecular Formula C17H19NO Average mass 253.339 Da Cas 13669-70-0 [RN] 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- 237-148-2 [EINECS] 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine SCX-001 Derivative Type: Hydrochloride CAS Registry Number: 23327-57-3 Additional Names: Fenazoxine SCX-001, R-738 Non-Opioid Analgesics Wound-Healing Agents Biocodex, 1983 pain Нефопама Гидрохлорид 塩酸ネホパム Nefopam, sold under the brand names Acupan among others, is a painkilling medication. It is primarily used to treat moderate, acuteor chronic pain. [3] …
Secnidazole, секнидазол , سيكنيدازول , 塞克硝唑 ,
It’s only fair to share… Secnidazole Molecular FormulaC7H11N3O3 Average mass185.180 Da 1-(2-Methyl-5-nitroimidazol-1-yl)-2-propanol 1H-Imidazole-1-ethanol, α,2-dimethyl-5-nitro- [ACD/Index Name] 222-134-0 [EINECS] 3366-95-8 [RN] a,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol UNII:R3459K699K секнидазол[Russian][INN] سيكنيدازول[Arabic][INN] 塞克硝唑[Chinese][INN] RP-14539, PM-185184, Flagentyl Company: Symbiomix Therapeutics Approval Status: Approved FDA September 2017 Specific Treatments: bacterial vaginosis Therapeutic Areas Obstetrics/Gynecology (Women’s Health) Infections and Infectious Diseases Solosec (secnidazole) ; Symbiomix Therapeutics; For the treatment of bacterial vaginosis , …
Enclomiphene citrate, New patent, WO 2017182097, F.I.S. – FABBRICA ITALIANA SINTETICI S.P.A
It’s only fair to share… Enclomiphene citrate, New patent, WO 2017182097, F.I.S. – FABBRICA ITALIANA SINTETICI S.P.A WO-2017182097 F.I.S. – FABBRICA ITALIANA SINTETICI S.P.A CARUANA, Lorenzo; (IT). PADOVAN, Pierluigi; (IT). DAL SANTO, Claudio; (IT) https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017182097&recNum=1&maxRec=&office=&prevFilter=&sortOption=&queryString=&tab=PCTDescription Enclomiphene citrate is an active pharmaceutical ingredient currently under evaluation in clinical phase III for the treatment of secondary hypergonadism. …
2,4-Diphenyl-2,3-dihydro-1,5-benzothiazepine
It’s only fair to share… 2,4-Diphenyl-2,3-dihydro-1,5-benzothiazepine (4a) 1,3-Diphenyl-2-propen-1-one (1a). Yellow solid; mp 114-116 C [lit.1 , 114-115 °C], AcOEt/PE 1:9. 1H NMR (300 MHz, CDCl3,): 3.07 (t, J = 12.6 Hz, 1 H), 3.32 (dd, J = 4.7, 13.1 Hz, 1 H), 4.99 (dd, J = 4.5, 12.0 Hz, 1 H), 7.12-7.17 (m, 1 H), …
BMS-986020
It’s only fair to share… BMS-986020 AM-152; BMS-986020; BMS-986202 cas 1257213-50-5 Chemical Formula: C29H26N2O5 Molecular Weight: 482.536 (R)-1-(4′-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1′-biphenyl]-4-yl)cyclopropane-1-carboxylic acid Cyclopropanecarboxylic acid, 1-(4′-(3-methyl-4-((((1R)-1-phenylethoxy)carbonyl)amino)-5-isoxazolyl)(1,1′-biphenyl)-4-yl)- 1-(4′-(3-Methyl-4-(((((R)-1-phenylethyl)oxy)carbonyl)amino)isoxazol-5-yl)biphenyl-4-yl)cyclopropanecarboxylic acid UNII: 38CTP01B4L For treatment for pulmonary fibrosis, phase 2, The lysophosphatidic acid receptor, LPA1, has been implicated as a therapeutic target for fibrotic disorders Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), …
AD 35
It’s only fair to share… AD 35 IND-120499 MF C24 H27 N3 O3 Molecular Weight, 405.49 Spiro[cyclopropane-1,5′-[5H-1,3]dioxolo[4,5-f]isoindol]-7′(6′H)-one, 6′-[2-[1-(2-pyridinylmethyl)-4-piperidinyl]ethyl]- 6′-[2-[1-(2-Pyridinylmethyl)-4-piperidinyl]ethyl]spiro[cyclopropane-1,5′-[5H-1,3]dioxolo[4,5-f]isoindol]-7′(6’H)-one 1531586-58-9 CAS FREE FORM 1531586-64-7 PHOSPHATE 1531586-62-5 HYDROCHLORIDE Zhejiang Hisun Pharmaceutical Co Ltd AD-35 is known to be a neuroprotectant, useful for treating Alzheimer’s diseases. Zhejiang Hisun Pharmaceutical is developing an oral tablet formulation of AD-35, for treating Alzheimers disease …
Novel lead compounds in pre-clinical development against African sleeping sickness
It’s only fair to share… Novel lead compounds in pre-clinical development against African sleeping sickness Med. Chem. Commun., 2017, 8,1872-1890 DOI: 10.1039/C7MD00280G, Review Article Michael Berninger, Ines Schmidt, Alicia Ponte-Sucre, Ulrike Holzgrabe This article reviews the recent progress in drug development against the African sleeping sickness. Novel lead compounds in pre-clinical development against African sleeping sickness …
1-(Ferrocenyl(phenyl)methyl)pyrrolidine
It’s only fair to share… 1-(Ferrocenyl(phenyl)methyl)pyrrolidine (1b) was obtained (2.14 g, 62% yield) as an orange solid. m.p. 100-102 oC; 1H NMR (400 MHz, CDCl3) δ 7.53 (d, J = 7.6 Hz, 2H), 7.38 (t, J = 7.6 Hz, 2H), 7.29 (t, J = 7.6 Hz, 1H), 4.18 (s, 2H), 4.12 (s, 1H), 4.07 …