Drug Approvals International – Page 77 – All about Drugs Live by Dr Anthony Melvin Crasto

Centhaquine

Centhaquine PMZ-2010 CAS 57961-90-7 2-[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]quinoline INDIA 2020, 14.05.2020, Centhaquine citrate bulk and Centhaquine citrate injection 1.0mg/vial, Add on resuscitative agent for hypovolemic shock OriginatorMidwestern University; Pharmazz DeveloperPharmazz ClassAnalgesics; Antihaemorrhagics; Antihypertensives; Cardiovascular therapies; Piperazines; Quinolines; Small molecules Mechanism of ActionAlpha 1 adrenergic receptor antagonists; Alpha 2 adrenergic receptor agonists RegisteredHaemorrhagic shock Phase IHeart arrest; Postoperative pain 20 Jul …

Esketamine

Esketamine Molecular FormulaC13H16ClNO Average mass237.725 Da (+)-Ketamine (2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone (S)-Ketamine 33643-46-8 [RN] 7884 Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2S)- Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (S)- Ketamine CAS Registry Number: 6740-88-1 CAS Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone Molecular Formula: C13H16ClNO Molecular Weight: 237.73 Percent Composition: C 65.68%, H 6.78%, Cl 14.91%, N 5.89%, O 6.73% Literature References: Prepn: C. L. Stevens, BE634208; idem,US3254124 (1963, 1966 both to Parke, Davis). Isoln of optical isomers: T. W. Hudyma et …

Inclisiran

Inclisiran CAS 1639324-58-5 ALN-60212 ALN-PCSsc Inclisiran was first developed by Alnylam Pharmaceuticals, Inc. (Cambridge, Massachusetts, US). Development has now been assumed by The Medicines Company (Parsippany, New Jersey, US). One phase I and two phase II trials have been completed. Topline results of two phase III trials were also recently presented while other phase III …

Ciglitazone

Ciglitazone U-63287, ADD-3878 Molecular FormulaC18H23NO3S Average mass333.445 Da 74772-77-3 [RN] (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione 2,4-Thiazolidinedione, 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]- 5-[4-(1-methylcyclohexylmethoxy) benzyl]-thiazolidine-2,4-dione Ciglitazone (INN) is a thiazolidinedione. Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class.[1][2][3][4] Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues were later developed, some of which—such …

BMS 262084

BMS-262084 CAS 253174-92-4 Molecular FormulaC18H31N7O5 Average mass425.483 Da NII-I0IR71971G I0IR71971G (2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylic acid (2S,3R)-1-{[4-(tert-butylcarbamoyl)piperazin-1-yl]carbonyl}-3-{3-[(diaminomethylidene)amino]propyl}-4-oxoazetidine-2-carboxylic acid (2S,3R)-3-{3-[(Diaminomethylene)amino]propyl}-1-({4-[(2-methyl-2-propanyl)carbamoyl]-1-piperazinyl}carbonyl)-4-oxo-2-azetidinecarboxylic acid 253174-92-4 [RN] 2-Azetidinecarboxylic acid, 3-[3-[(diaminomethylene)amino]propyl]-1-[[4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]carbonyl]-4-oxo-, (2S,3R)- Factor XIa inhibitors (thrombosis), BMS; Factor XIa inhibitors (thrombosis), Bristol-Myers Squibb; BMS-654457; Factor XIa inhibitors (cardiovascular diseases), BMS; BMS-724296 Novel crystalline forms of BMS-262084 as Factor XIa antagonist useful for treating cardiovascular diseases. PHASE 2 …

Tazemetostat

Tazemetostat Current developer: Epizyme, Inc., Cambridge, MA 02139. EPZ-6438 (Tazemetostat) CAS: 1403254-99-8 HBR 1467052-75-0 タゼメトスタット臭化水素酸塩 Current developer: Epizyme, Inc., Cambridge, MA 02139. EPZ-6438 (Tazemetostat) CAS: 1403254-99-8 HBR Chemical Formula: C34H44N4O4 Exact Mass: 572.33626 USFDA APPROVED 23/1/2020 AS HBR SALT, TAZVERIK, EPIZYME N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide SIMLES: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O (1,1′-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(4-morpholinylmethyl)- N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(oxan-4-yl)amino)-4-methyl-4′-((morpholin-4-yl)methyl)(1,1′-biphenyl)-3-carboxamide UNII-Q40W93WPE1 Tazemetostat, sold under the …

PERAMIVIR

PERAMIVIR CAS 330600-85-6 Molecular FormulaC15H28N4O4 Average mass328.407 Da (1S,2S,3R,4R)-4-carbamimidamido-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid RWJ 270201 RWJ-270201 RWJ270201 (1S,2S,3R,4R)-3-(1-Acetamido-2-ethylbutyl)-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid [ACD/IUPAC Name] (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic Acid (1S,2S,3R,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-carbamimidamido-2-hydroxycyclopentanecarboxylic acid 229614-56-6 [RN] 330600-85-6 [RN] 8184 9ZS94HQO3B Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase …

IDEBENONE

IDEBENONE 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone Molecular FormulaC19H30O5 Average mass338.439 Da 58186-27-9 Idebenona, Idebenonum, CV 2619 Idesol KS-5193 Nemocebral SNT-MC17 идебенон إيديبينون 艾地苯醌 Puldysa (idebenone), for the treatment of Duchenne muscular dystrophy Title: Idebenone CAS Registry Number: 58186-27-9 CAS Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione Additional Names: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone; 2,3-dimethoxy-5-methyl-6-(10¢-hydroxydecyl)-1,4-benzoquinone; 6-(10-hydroxydecyl)ubiquinone Manufacturers’ Codes: CV-2619 Trademarks: Avan (Takeda); Daruma (Takeda); Lucebanol (Hormona); Mnesis (Takeda) Molecular Formula: C19H30O5 Molecular Weight: 338.44 Percent Composition: C 67.43%, H 8.93%, O …

PF 3635659

PF-3635659 CAS 931409-24-4 FREE FORM Molecular Formula, C28-H32-N2-O3, Molecular Weight, 444.5718 1-Azetidinepentanamide, 3-(3-hydroxyphenoxy)-delta,delta-dimethyl-alpha,alpha-diphenyl- 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide;hydrochloride Molecular Formula C28H33ClN2O3 Synonyms PF-3635659 (hydrochloride) 1079781-31-9 5-[3-(3-Hydroxy-phenoxy)-azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanoic acid amide hydrochloride Molecular Weight 481 g/mol READ www.soci.org › David_Price_Presentation_0945_1030 PDF Discovery of PF–3635659. An Inhaled Once. An Inhaled Once-daily M3. A t. i t. A t. i t f A th & COPD f …

BINDARIT

BINDARIT Molecular FormulaC19H20N2O3 Average mass324.374 Da CAS 130641-38-2 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1 -benzyl-1 H-indazol-3-yl)methoxy]-2-methylpropanoic acid 2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid JQ11LH711M Propanoic acid, 2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]- [ACD/Index Name] биндарит [Russian] [INN] بينداريت [Arabic] [INN] 宾达利 [Chinese] [INN] PHASE 2 Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss …